AXSM vs SPY
Comparison between Axsome Therapeutics Inc (AXSM, Company) and SPDR S&P 500 ETF Trust (SPY, ETF).
5-Year PerformanceAXSM has outperformed SPY, delivering a return of +30.7% compared to +13.3%
AXSM vs SPY - Performance Comparison
Key Characteristics
Financial metrics and valuation ratios
Market Cap / Net Assets
AXSM
$11B
Winner
SPY
$652B
Expense Ratio
AXSM
N/A
SPY
0.09%
Max Drawdown
AXSM
86.65%
Winner
SPY
56.47%
Sharpe Ratio
AXSM
1.74
Winner
SPY
2.07
5Y Beta
Winner
AXSM
0.68
SPY
1.00
Industry
AXSM
Biotechnology
SPY
N/A
P/E Ratio
Winner
AXSM
-59.87
SPY
28.24
Forward P/E
AXSM
333.33
Winner
SPY
21.85
PEG Ratio
AXSM
0.00
SPY
N/A
5Y Dividends CAGR
AXSM
N/A
SPY
5.43%
5Y EPS CAGR
AXSM
6.89%
Winner
SPY
25.79%
Debt to Equity
AXSM
344.13%
Winner
SPY
22.35%
Free Cash Flow Yield
AXSM
-0.62%
SPY
N/A
P/S Ratio
AXSM
15.79
Winner
SPY
3.55
P/B Ratio
AXSM
210.80
Winner
SPY
5.29
AXSM vs SPY - Historical Returns
Returns include dividend reinvestment.
1M
Winner
AXSM
+25.52%
SPY
+9.11%
3M
Winner
AXSM
+18.64%
SPY
+6.59%
6M
Winner
AXSM
+57.35%
SPY
+10.56%
1Y
Winner
AXSM
+99.69%
SPY
+32.04%
5Y(CAGR)
Winner
AXSM
+30.70%
SPY
+13.35%
10Y(CAGR)
Winner
AXSM
+34.69%
SPY
+15.49%
Max(CAGR)
Winner
AXSM
+35.94%
SPY
+8.50%
AXSM vs SPY - Annual Returns (1999 - 2026)
Returns include dividend reinvestment.
| Year | AXSM | SPY |
|---|---|---|
| 2026 | +21.65% | +8.27% |
| 2025 | +109.16% | +18.00% |
| 2024 | +9.80% | +25.59% |
| 2023 | +8.55% | +26.72% |
| 2022 | +103.89% | -18.64% |
| 2021 | -53.61% | +30.52% |
| 2020 | -19.58% | +17.28% |
| 2019 | +3756.72% | +31.09% |
| 2018 | -48.49% | -5.24% |
| 2017 | -13.18% | +20.78% |
| 2016 | -44.63% | +13.59% |
| 2015 | +6.06% | +1.31% |
| 2014 | N/A | +14.56% |
| 2013 | N/A | +29.00% |
| 2012 | N/A | +14.17% |
| 2011 | N/A | +0.85% |
| 2010 | N/A | +13.14% |
| 2009 | N/A | +22.67% |
| 2008 | N/A | -36.25% |
| 2007 | N/A | +5.32% |
| 2006 | N/A | +13.85% |
| 2005 | N/A | +5.32% |
| 2004 | N/A | +10.75% |
| 2003 | N/A | +24.18% |
| 2002 | N/A | -22.42% |
| 2001 | N/A | -10.13% |
| 2000 | N/A | -8.84% |
| 1999 | N/A | +8.61% |
AXSM vs SPY Drawdown Comparison
The maximum drawdown for AXSM was -86.65%, occurring on Dec 27, 2018. Recovery took 809 trading sessions.
The maximum drawdown for SPY was -55.20%, occurring on Mar 9, 2009. Recovery took 1224 trading sessions.
The current AXSM drawdown is -2.83%.
| Rank | AXSM | SPY |
|---|---|---|
| #1 | -86.65% Jan 5, 2016 - Mar 25, 2019 | -55.20% Oct 9, 2007 - Aug 16, 2012 |
| #2 | -81.26% Dec 26, 2019 - Jan 30, 2025 | -47.50% Mar 24, 2000 - Oct 26, 2006 |
| #3 | -42.70% Sep 16, 2019 - Nov 19, 2019 | -33.70% Feb 19, 2020 - Aug 10, 2020 |
| #4 | -30.56% Feb 21, 2025 - Nov 6, 2025 | -24.50% Jan 3, 2022 - Dec 13, 2023 |
| #5 | -18.50% Jan 21, 2026 - Apr 30, 2026 | -19.34% Sep 20, 2018 - Apr 12, 2019 |
| #6 | -17.63% Mar 25, 2019 - Apr 25, 2019 | -18.76% Feb 19, 2025 - Jun 26, 2025 |
| #7 | -17.48% Jul 26, 2019 - Sep 16, 2019 | -13.02% Jul 20, 2015 - Apr 18, 2016 |
| #8 | -17.26% May 28, 2019 - Jun 20, 2019 | -10.10% Jan 26, 2018 - Aug 6, 2018 |
| #9 | -11.38% Jun 20, 2019 - Jun 27, 2019 | -9.44% Sep 2, 2020 - Nov 11, 2020 |
| #10 | -10.33% Nov 24, 2015 - Dec 29, 2015 | -9.30% Jan 19, 2000 - Mar 17, 2000 |
| #11 | -9.37% Jul 2, 2019 - Jul 26, 2019 | -9.05% Jul 19, 2007 - Oct 5, 2007 |
| #12 | -8.83% Dec 4, 2019 - Dec 10, 2019 | -8.88% Jan 27, 2026 - Apr 14, 2026 |
| #13 | -8.26% Dec 31, 2025 - Jan 20, 2026 | -8.41% Jul 16, 2024 - Sep 19, 2024 |
| #14 | -7.23% Feb 5, 2025 - Feb 10, 2025 | -7.35% Sep 14, 2012 - Jan 2, 2013 |
| #15 | -6.21% Nov 28, 2025 - Dec 19, 2025 | -7.27% Sep 18, 2014 - Oct 31, 2014 |
Correlation
Correlation between AXSM and SPY is 0.88 which considered as a strong positive correlation - the stocks tend to move together.
0.88
-101
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