AXSM vs MDGL

Comparison between Axsome Therapeutics Inc (AXSM, Company) and Madrigal Pharmaceuticals Inc (MDGL, Company).

Both AXSM and MDGL are from the Healthcare sector.

5-Year PerformanceMDGL has outperformed AXSM, delivering a return of +35.6% compared to +33.0%

AXSM vs MDGL - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	AXSM(COMPANY)	MDGL(COMPANY)
Market Cap	$12B	$12B
Max Drawdown	86.65%	98.40%
Sharpe Ratio	2.07	1.60
5Y Beta	0.68	0.75
Industry	Biotechnology	Biotechnology
P/E Ratio	-62.02	-37.77
Forward P/E	333.33	666.67
PEG Ratio	0.00	0.00
5Y EPS CAGR	6.89%	23.26%
Debt to Equity	344.13%	62.62%
Free Cash Flow Yield	-0.60%	-2.31%
P/S Ratio	16.82	10.37
P/B Ratio	217.41	21.78

Market Cap

Winner

AXSM

$12B

MDGL

$12B

Max Drawdown

Winner

AXSM

86.65%

MDGL

98.40%

Sharpe Ratio

Winner

AXSM

2.07

MDGL

1.60

5Y Beta

Winner

AXSM

0.68

MDGL

0.75

Industry

AXSM

Biotechnology

MDGL

Biotechnology

P/E Ratio

Winner

AXSM

-62.02

MDGL

-37.77

Forward P/E

Winner

AXSM

333.33

MDGL

666.67

PEG Ratio

AXSM

0.00

MDGL

0.00

5Y EPS CAGR

AXSM

6.89%

Winner

MDGL

23.26%

Debt to Equity

AXSM

344.13%

Winner

MDGL

62.62%

Free Cash Flow Yield

Winner

AXSM

-0.60%

MDGL

-2.31%

P/S Ratio

AXSM

16.82

Winner

MDGL

10.37

P/B Ratio

AXSM

217.41

Winner

MDGL

21.78

AXSM vs MDGL - Historical Returns

Returns include dividend reinvestment.

Period	AXSM	MDGL
1 month	+24.97%	+0.81%
3 months	+43.51%	+17.59%
6 months	+55.12%	-12.77%
1 year	+125.24%	+93.06%
5 years(CAGR)	+33.03%	+35.64%
10 years(CAGR)	+38.89%	+45.17%
Max(CAGR)	+36.71%	+2.62%

Winner

AXSM

+24.97%

MDGL

+0.81%

Winner

AXSM

+43.51%

MDGL

+17.59%

Winner

AXSM

+55.12%

MDGL

-12.77%

Winner

AXSM

+125.24%

MDGL

+93.06%

5Y(CAGR)

AXSM

+33.03%

Winner

MDGL

+35.64%

10Y(CAGR)

AXSM

+38.89%

Winner

MDGL

+45.17%

Max(CAGR)

Winner

AXSM

+36.71%

MDGL

+2.62%

AXSM vs MDGL - Annual Returns (2007 - 2026)

Returns include dividend reinvestment.

Year	AXSM	MDGL
2026	+31.06%	-11.72%
2025	+109.16%	+85.59%
2024	+9.80%	+36.02%
2023	+8.55%	-18.93%
2022	+103.89%	+222.07%
2021	-53.61%	-22.80%
2020	-19.58%	+22.60%
2019	+3756.72%	-18.06%
2018	-48.49%	+15.71%
2017	-13.18%	+475.13%
2016	-44.63%	+28.97%
2015	+6.06%	-87.74%
2014	N/A	-49.62%
2013	N/A	-45.64%
2012	N/A	+84.46%
2011	N/A	-24.56%
2010	N/A	+10.87%
2009	N/A	-17.99%
2008	N/A	-3.62%
2007	N/A	-26.29%

AXSM vs MDGL Drawdown Comparison

The maximum drawdown for AXSM was -86.65%, occurring on Dec 27, 2018. Recovery took 809 trading sessions.

The maximum drawdown for MDGL was -98.40%, occurring on Feb 11, 2016. Recovery took 3162 trading sessions.

The current AXSM drawdown is -0.75%. The current MDGL drawdown is -13.03%.

Rank	AXSM	MDGL
#1	-86.65% Jan 5, 2016 - Mar 25, 2019	-98.40% Jan 28, 2013 - Aug 22, 2025
#2	-81.26% Dec 26, 2019 - Jan 30, 2025	-87.64% Oct 5, 2007 - Jan 22, 2013
#3	-42.70% Sep 16, 2019 - Nov 19, 2019	-51.43% Jun 4, 2007 - Oct 4, 2007
#4	-30.56% Feb 21, 2025 - Nov 6, 2025	-29.36% Dec 22, 2025 - Mar 3, 2026
#5	-18.50% Jan 21, 2026 - Apr 30, 2026	-18.88% Feb 9, 2007 - Jun 4, 2007
#6	-17.63% Mar 25, 2019 - Apr 25, 2019	-10.10% Sep 30, 2025 - Nov 5, 2025
#7	-17.48% Jul 26, 2019 - Sep 16, 2019	-9.42% Nov 26, 2025 - Dec 22, 2025
#8	-17.26% May 28, 2019 - Jun 20, 2019	-8.01% Sep 8, 2025 - Sep 30, 2025
#9	-11.38% Jun 20, 2019 - Jun 27, 2019	-4.91% Nov 11, 2025 - Nov 17, 2025
#10	-10.33% Nov 24, 2015 - Dec 29, 2015	-4.32% Jan 23, 2013 - Jan 25, 2013
#11	-9.37% Jul 2, 2019 - Jul 26, 2019	-3.02% Nov 18, 2025 - Nov 24, 2025
#12	-8.83% Dec 4, 2019 - Dec 10, 2019	-1.52% Aug 29, 2025 - Sep 8, 2025
#13	-8.26% Dec 31, 2025 - Jan 20, 2026	-0.59% Aug 22, 2025 - Aug 26, 2025
#14	-7.23% Feb 5, 2025 - Feb 10, 2025	N/A
#15	-6.21% Nov 28, 2025 - Dec 19, 2025	N/A