APLS vs SPY

Comparison between Apellis Pharmaceuticals Inc (APLS, Company) and SPDR S&P 500 ETF Trust (SPY, ETF).

5-Year PerformanceSPY has outperformed APLS, delivering a return of +13.8% compared to -1.5%

APLS vs SPY - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	APLS(COMPANY)	SPY(ETF)
Market Cap / Net Assets	$5.25B	$735B
Expense Ratio	N/A	0.09%
Max Drawdown	82.47%	56.47%
Sharpe Ratio	1.03	1.67
5Y Beta	N/A	1.00
Industry	Biotechnology	N/A
P/E Ratio	39.02	28.81
Forward P/E	46.30	22.07
5Y Dividends CAGR	N/A	5.43%
5Y EPS CAGR	N/A	25.84%
Debt to Equity	22.59%	34.16%
Free Cash Flow Yield	0.71%	N/A
P/S Ratio	4.75	3.69
P/B Ratio	12.66	5.54

Market Cap / Net Assets

APLS

$5.25B

Winner

SPY

$735B

Expense Ratio

APLS

N/A

SPY

0.09%

Max Drawdown

APLS

82.47%

Winner

SPY

56.47%

Sharpe Ratio

APLS

1.03

Winner

SPY

1.67

5Y Beta

APLS

N/A

SPY

1.00

Industry

APLS

Biotechnology

SPY

N/A

P/E Ratio

APLS

39.02

Winner

SPY

28.81

Forward P/E

APLS

46.30

Winner

SPY

22.07

5Y Dividends CAGR

APLS

N/A

SPY

5.43%

5Y EPS CAGR

APLS

N/A

SPY

25.84%

Debt to Equity

Winner

APLS

22.59%

SPY

34.16%

Free Cash Flow Yield

APLS

0.71%

SPY

N/A

P/S Ratio

APLS

4.75

Winner

SPY

3.69

P/B Ratio

APLS

12.66

Winner

SPY

5.54

APLS vs SPY - Historical Returns

Returns include dividend reinvestment.

Period	APLS	SPY
1 month	+0.44%	+4.59%
3 months	+89.08%	+7.81%
6 months	+101.82%	+14.24%
1 year	+145.69%	+26.47%
5 years(CAGR)	-1.50%	+13.84%
10 years(CAGR)	+13.44%	+15.57%
Max(CAGR)	+13.44%	+8.50%

APLS

+0.44%

Winner

SPY

+4.59%

Winner

APLS

+89.08%

SPY

+7.81%

Winner

APLS

+101.82%

SPY

+14.24%

Winner

APLS

+145.69%

SPY

+26.47%

5Y(CAGR)

APLS

-1.50%

Winner

SPY

+13.84%

10Y(CAGR)

APLS

+13.44%

Winner

SPY

+15.57%

Max(CAGR)

Winner

APLS

+13.44%

SPY

+8.50%

APLS vs SPY - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	APLS	SPY
2026	+58.66%	+8.80%
2025	-24.25%	+18.00%
2024	-47.92%	+25.59%
2023	+19.05%	+26.72%
2022	+6.03%	-18.64%
2021	-13.39%	+30.52%
2020	+83.54%	+17.28%
2019	+124.82%	+31.09%
2018	-36.53%	-5.24%
2017	+54.67%	+20.78%
2016	N/A	+13.59%
2015	N/A	+1.31%
2014	N/A	+14.56%
2013	N/A	+29.00%
2012	N/A	+14.17%
2011	N/A	+0.85%
2010	N/A	+13.14%
2009	N/A	+22.67%
2008	N/A	-36.25%
2007	N/A	+5.32%
2006	N/A	+13.85%
2005	N/A	+5.32%
2004	N/A	+10.75%
2003	N/A	+24.18%
2002	N/A	-22.42%
2001	N/A	-10.13%
2000	N/A	-8.84%
1999	N/A	+8.61%

APLS vs SPY Drawdown Comparison

The maximum drawdown for APLS was -82.47%, occurring on May 15, 2025. This drawdown has not yet recovered.

The maximum drawdown for SPY was -55.20%, occurring on Mar 9, 2009. Recovery took 1224 trading sessions.

The current APLS drawdown is -56.03%. The current SPY drawdown is -0.92%.

Rank	APLS	SPY
#1	-82.47% Jun 13, 2023 - May 15, 2025	-55.20% Oct 9, 2007 - Aug 16, 2012
#2	-61.77% Apr 16, 2018 - Sep 5, 2019	-47.50% Mar 24, 2000 - Oct 26, 2006
#3	-59.60% Feb 10, 2020 - Nov 20, 2020	-33.70% Feb 19, 2020 - Aug 10, 2020
#4	-55.99% Jul 2, 2021 - Apr 3, 2023	-24.50% Jan 3, 2022 - Dec 13, 2023
#5	-43.83% Jan 4, 2018 - Mar 14, 2018	-19.34% Sep 20, 2018 - Apr 12, 2019
#6	-31.32% Sep 6, 2019 - Jan 7, 2020	-18.76% Feb 19, 2025 - Jun 26, 2025
#7	-28.91% Jan 8, 2021 - Jun 1, 2021	-13.02% Jul 20, 2015 - Apr 18, 2016
#8	-21.52% Mar 16, 2018 - Apr 11, 2018	-10.10% Jan 26, 2018 - Aug 6, 2018
#9	-12.47% Dec 11, 2017 - Dec 21, 2017	-9.44% Sep 2, 2020 - Nov 11, 2020
#10	-8.62% May 5, 2023 - Jun 13, 2023	-9.30% Jan 19, 2000 - Mar 17, 2000
#11	-8.38% Dec 8, 2020 - Dec 15, 2020	-9.05% Jul 19, 2007 - Oct 5, 2007
#12	-8.03% Jun 14, 2021 - Jul 1, 2021	-8.88% Jan 27, 2026 - Apr 14, 2026
#13	-6.75% Apr 24, 2023 - May 5, 2023	-8.41% Jul 16, 2024 - Sep 19, 2024
#14	-6.20% Jan 21, 2020 - Feb 3, 2020	-7.35% Sep 14, 2012 - Jan 2, 2013
#15	-5.53% Nov 13, 2017 - Dec 8, 2017	-7.27% Sep 18, 2014 - Oct 31, 2014