ALGN vs IONS

Comparison between Align Technology Inc (ALGN, Company) and Ionis Pharmaceuticals Inc (IONS, Company).

Both ALGN and IONS are from the Healthcare sector.

5-Year PerformanceIONS has outperformed ALGN, delivering a return of +14.1% compared to -22.1%

ALGN vs IONS - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	ALGN(COMPANY)	IONS(COMPANY)
Market Cap	$12B	$12B
Max Drawdown	92.30%	91.72%
Sharpe Ratio	0.12	1.65
5Y Beta	1.33	0.73
Industry	Medical Instruments & Supplies	Biotechnology
P/E Ratio	28.49	-69.58
Forward P/E	15.38	90.91
PEG Ratio	3.44	-1.47
5Y EPS CAGR	0.63%	-21.44%
Debt to Equity	0.00%	88.01%
Free Cash Flow Yield	4.78%	-7.98%
P/S Ratio	3.11	11.72
P/B Ratio	3.07	25.08

Market Cap

Winner

ALGN

$12B

IONS

$12B

Max Drawdown

ALGN

92.30%

Winner

IONS

91.72%

Sharpe Ratio

ALGN

0.12

Winner

IONS

1.65

5Y Beta

ALGN

1.33

Winner

IONS

0.73

Industry

ALGN

Medical Instruments & Supplies

IONS

Biotechnology

P/E Ratio

ALGN

28.49

Winner

IONS

-69.58

Forward P/E

Winner

ALGN

15.38

IONS

90.91

PEG Ratio

ALGN

3.44

Winner

IONS

-1.47

5Y EPS CAGR

Winner

ALGN

0.63%

IONS

-21.44%

Debt to Equity

Winner

ALGN

0.00%

IONS

88.01%

Free Cash Flow Yield

Winner

ALGN

4.78%

IONS

-7.98%

P/S Ratio

Winner

ALGN

3.11

IONS

11.72

P/B Ratio

Winner

ALGN

3.07

IONS

25.08

ALGN vs IONS - Historical Returns

Returns include dividend reinvestment.

Period	ALGN	IONS
1 month	+5.46%	-3.37%
3 months	+4.74%	+1.29%
6 months	+5.69%	-9.34%
1 year	-3.77%	+105.71%
5 years(CAGR)	-22.14%	+14.07%
10 years(CAGR)	+8.38%	+13.07%
Max(CAGR)	+9.66%	+7.47%

Winner

ALGN

+5.46%

IONS

-3.37%

Winner

ALGN

+4.74%

IONS

+1.29%

Winner

ALGN

+5.69%

IONS

-9.34%

ALGN

-3.77%

Winner

IONS

+105.71%

5Y(CAGR)

ALGN

-22.14%

Winner

IONS

+14.07%

10Y(CAGR)

ALGN

+8.38%

Winner

IONS

+13.07%

Max(CAGR)

Winner

ALGN

+9.66%

IONS

+7.47%

ALGN vs IONS - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	ALGN	IONS
2026	+12.06%	-8.03%
2025	-25.10%	+128.05%
2024	-22.46%	-33.88%
2023	+29.07%	+34.62%
2022	-67.46%	+15.86%
2021	+24.83%	-46.41%
2020	+88.37%	-7.14%
2019	+38.06%	+12.35%
2018	-6.76%	+9.77%
2017	+129.16%	+6.25%
2016	+49.57%	-22.45%
2015	+17.17%	+0.58%
2014	-1.84%	+54.85%
2013	+101.20%	+268.21%
2012	+15.87%	+44.00%
2011	+19.40%	-29.93%
2010	+5.62%	-10.20%
2009	+100.45%	-23.22%
2008	-46.87%	-7.80%
2007	+24.94%	+44.10%
2006	+122.45%	+111.81%
2005	-38.73%	-9.66%
2004	-35.59%	-13.36%
2003	+502.77%	-4.97%
2002	-35.79%	-68.69%
2001	-73.34%	+130.55%
2000	N/A	+77.49%
1999	N/A	-44.34%

ALGN vs IONS Drawdown Comparison

The maximum drawdown for ALGN was -92.30%, occurring on Nov 13, 2002. Recovery took 692 trading sessions.

The maximum drawdown for IONS was -91.43%, occurring on Mar 18, 2003. Recovery took 3357 trading sessions.

The current ALGN drawdown is -76.05%. The current IONS drawdown is -15.29%.

Rank	ALGN	IONS
#1	-92.30% Jan 30, 2001 - Nov 3, 2003	-91.43% Mar 6, 2000 - Jul 11, 2013
#2	-82.89% Sep 8, 2021 - Sep 25, 2025	-73.25% Mar 19, 2015 - Mar 14, 2019
#3	-82.58% Oct 24, 2007 - Apr 24, 2012	-70.39% Apr 8, 2019 - Feb 6, 2026
#4	-75.18% Apr 19, 2004 - Apr 26, 2007	-68.14% Dec 2, 1999 - Mar 1, 2000
#5	-64.95% Sep 25, 2018 - Oct 22, 2020	-61.05% Feb 21, 2014 - Dec 10, 2014
#6	-35.18% Sep 13, 2012 - Jul 10, 2013	-28.35% Jul 12, 2013 - Sep 19, 2013
#7	-30.62% Jan 17, 2014 - Jun 16, 2015	-20.89% Sep 23, 2013 - Nov 27, 2013
#8	-22.28% Jan 26, 2018 - May 11, 2018	-19.78% Jan 12, 2015 - Mar 19, 2015
#9	-20.05% Feb 5, 2021 - Apr 27, 2021	-19.45% Feb 6, 2026 - Mar 24, 2026
#10	-18.56% Jul 25, 2007 - Oct 4, 2007	-11.84% Dec 12, 2014 - Dec 19, 2014
#11	-18.32% Jul 20, 2015 - Oct 23, 2015	-11.49% Dec 19, 2014 - Jan 5, 2015
#12	-17.71% Jan 26, 2004 - Apr 12, 2004	-8.95% Jan 31, 2014 - Feb 13, 2014
#13	-17.21% Nov 28, 2017 - Jan 17, 2018	-8.58% Nov 11, 1999 - Nov 17, 1999
#14	-14.67% Dec 1, 2003 - Jan 7, 2004	-7.67% Jan 22, 2014 - Jan 31, 2014
#15	-14.09% Oct 26, 2015 - Mar 2, 2016	-7.49% Dec 23, 2013 - Jan 8, 2014