AGEN vs SPY

Comparison between Agenus Inc (AGEN, Company) and SPDR S&P 500 ETF Trust (SPY, ETF).

5-Year PerformanceSPY has outperformed AGEN, delivering a return of +14.1% compared to -46.9%

AGEN vs SPY - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	AGEN(COMPANY)	SPY(ETF)
Market Cap / Net Assets	$131M	$735B
Expense Ratio	N/A	0.09%
Max Drawdown	99.98%	56.47%
Sharpe Ratio	0.40	2.00
5Y Beta	1.40	1.00
Industry	Biotechnology	N/A
P/E Ratio	2.05	28.99
Forward P/E	1.55	22.43
PEG Ratio	1.44	N/A
5Y Dividends CAGR	N/A	5.43%
5Y EPS CAGR	N/A	26.05%
Debt to Equity	-27.30%	32.40%
Free Cash Flow Yield	-66.63%	N/A
P/S Ratio	1.15	3.74
P/B Ratio	218.61	5.61

Market Cap / Net Assets

AGEN

$131M

Winner

SPY

$735B

Expense Ratio

AGEN

N/A

SPY

0.09%

Max Drawdown

AGEN

99.98%

Winner

SPY

56.47%

Sharpe Ratio

AGEN

0.40

Winner

SPY

2.00

5Y Beta

AGEN

1.40

Winner

SPY

1.00

Industry

AGEN

Biotechnology

SPY

N/A

P/E Ratio

Winner

AGEN

2.05

SPY

28.99

Forward P/E

Winner

AGEN

1.55

SPY

22.43

PEG Ratio

AGEN

1.44

SPY

N/A

5Y Dividends CAGR

AGEN

N/A

SPY

5.43%

5Y EPS CAGR

AGEN

N/A

SPY

26.05%

Debt to Equity

Winner

AGEN

-27.30%

SPY

32.40%

Free Cash Flow Yield

AGEN

-66.63%

SPY

N/A

P/S Ratio

Winner

AGEN

1.15

SPY

3.74

P/B Ratio

AGEN

218.61

Winner

SPY

5.61

AGEN vs SPY - Historical Returns

Returns include dividend reinvestment.

Period	AGEN	SPY
1 month	-11.98%	+5.40%
3 months	+1.20%	+10.97%
6 months	-18.94%	+12.09%
1 year	-18.16%	+29.62%
5 years(CAGR)	-46.88%	+14.12%
10 years(CAGR)	-27.85%	+15.55%
Max(CAGR)	-24.47%	+8.59%

AGEN

-11.98%

Winner

SPY

+5.40%

AGEN

+1.20%

Winner

SPY

+10.97%

AGEN

-18.94%

Winner

SPY

+12.09%

AGEN

-18.16%

Winner

SPY

+29.62%

5Y(CAGR)

AGEN

-46.88%

Winner

SPY

+14.12%

10Y(CAGR)

AGEN

-27.85%

Winner

SPY

+15.55%

Max(CAGR)

AGEN

-24.47%

Winner

SPY

+8.59%

AGEN vs SPY - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	AGEN	SPY
2026	+4.64%	+11.49%
2025	+1.62%	+18.00%
2024	-82.88%	+25.59%
2023	-64.85%	+26.72%
2022	-30.84%	-18.64%
2021	-0.31%	+30.52%
2020	-21.29%	+17.28%
2019	+62.15%	+31.09%
2018	-32.77%	-5.24%
2017	-21.63%	+20.78%
2016	-7.62%	+13.59%
2015	+14.07%	+1.31%
2014	+42.81%	+14.56%
2013	-37.74%	+29.00%
2012	+88.94%	+14.17%
2011	-68.55%	+0.85%
2010	+57.17%	+13.14%
2009	+33.33%	+22.67%
2008	-76.92%	-36.25%
2007	+6.25%	+5.32%
2006	-61.80%	+13.85%
2005	-52.40%	+5.32%
2004	-11.69%	+10.75%
2003	+5.98%	+24.18%
2002	-33.89%	-22.42%
2001	+48.28%	-10.13%
2000	-76.09%	-8.84%
1999	N/A	+8.61%

AGEN vs SPY Drawdown Comparison

The maximum drawdown for AGEN was -99.98%, occurring on Mar 31, 2025. This drawdown has not yet recovered.

The maximum drawdown for SPY was -55.20%, occurring on Mar 9, 2009. Recovery took 1224 trading sessions.

The current AGEN drawdown is -99.95%.

Rank	AGEN	SPY
#1	-99.98% Mar 9, 2000 - Mar 31, 2025	-55.20% Oct 9, 2007 - Aug 16, 2012
#2	-23.90% Feb 16, 2000 - Mar 9, 2000	-47.50% Mar 24, 2000 - Oct 26, 2006
#3	-6.50% Feb 10, 2000 - Feb 15, 2000	-33.70% Feb 19, 2020 - Aug 10, 2020
#4	-4.86% Feb 8, 2000 - Feb 10, 2000	-24.50% Jan 3, 2022 - Dec 13, 2023
#5	N/A	-19.34% Sep 20, 2018 - Apr 12, 2019
#6	N/A	-18.76% Feb 19, 2025 - Jun 26, 2025
#7	N/A	-13.02% Jul 20, 2015 - Apr 18, 2016
#8	N/A	-10.10% Jan 26, 2018 - Aug 6, 2018
#9	N/A	-9.44% Sep 2, 2020 - Nov 11, 2020
#10	N/A	-9.30% Jan 19, 2000 - Mar 17, 2000
#11	N/A	-9.05% Jul 19, 2007 - Oct 5, 2007
#12	N/A	-8.88% Jan 27, 2026 - Apr 14, 2026
#13	N/A	-8.41% Jul 16, 2024 - Sep 19, 2024
#14	N/A	-7.35% Sep 14, 2012 - Jan 2, 2013
#15	N/A	-7.27% Sep 18, 2014 - Oct 31, 2014

Correlation

Correlation between AGEN and SPY is -0.42 which considered as a weak negative correlation - the stocks show a slight tendency to move in opposite directions.

-0.42

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