AGEN vs OBIO

Comparison between Agenus Inc (AGEN, Company) and Orchestra BioMed Holdings Inc (OBIO, Company).

Both AGEN and OBIO are from the Healthcare sector.

5-Year PerformanceOBIO has outperformed AGEN, delivering a return of -18.3% compared to -43.8%

AGEN vs OBIO - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	AGEN(COMPANY)	OBIO(COMPANY)
Market Cap	$213M	$213M
Max Drawdown	99.98%	89.40%
Sharpe Ratio	0.36	0.49
5Y Beta	1.12	1.66
Industry	Biotechnology	Biotechnology
P/E Ratio	3.32	-3.26
Forward P/E	2.28	N/A
Debt to Equity	-27.30%	36.41%
Free Cash Flow Yield	-41.09%	-25.88%

Market Cap

Winner

AGEN

$213M

OBIO

$213M

Max Drawdown

AGEN

99.98%

Winner

OBIO

89.40%

Sharpe Ratio

AGEN

0.36

Winner

OBIO

0.49

5Y Beta

Winner

AGEN

1.12

OBIO

1.66

Industry

AGEN

Biotechnology

OBIO

Biotechnology

P/E Ratio

AGEN

3.32

Winner

OBIO

-3.26

Forward P/E

AGEN

2.28

OBIO

N/A

Debt to Equity

Winner

AGEN

-27.30%

OBIO

36.41%

Free Cash Flow Yield

AGEN

-41.09%

Winner

OBIO

-25.88%

AGEN vs OBIO - Historical Returns

Returns include dividend reinvestment.

Period	AGEN	OBIO
1 month	+101.63%	-9.90%
3 months	+64.63%	-12.29%
6 months	+91.05%	-9.90%
1 year	+1.98%	+14.11%
5 years(CAGR)	-43.79%	-18.30%
10 years(CAGR)	-23.80%	N/A
Max(CAGR)	-22.61%	-17.42%

Winner

AGEN

+101.63%

OBIO

-9.90%

Winner

AGEN

+64.63%

OBIO

-12.29%

Winner

AGEN

+91.05%

OBIO

-9.90%

AGEN

+1.98%

Winner

OBIO

+14.11%

5Y(CAGR)

AGEN

-43.79%

Winner

OBIO

-18.30%

10Y(CAGR)

AGEN

-23.80%

OBIO

N/A

Max(CAGR)

AGEN

-22.61%

Winner

OBIO

-17.42%

AGEN vs OBIO - Annual Returns (2000 - 2026)

Returns include dividend reinvestment.

Year	AGEN	OBIO
2026	+91.64%	-15.55%
2025	+1.62%	-22.86%
2024	-82.88%	-54.44%
2023	-64.85%	-9.06%
2022	-30.84%	+0.71%
2021	-0.31%	-22.46%
2020	-21.29%	+12.37%
2019	+62.15%	N/A
2018	-32.77%	N/A
2017	-21.63%	N/A
2016	-7.62%	N/A
2015	+14.07%	N/A
2014	+42.81%	N/A
2013	-37.74%	N/A
2012	+88.94%	N/A
2011	-68.55%	N/A
2010	+57.17%	N/A
2009	+33.33%	N/A
2008	-76.92%	N/A
2007	+6.25%	N/A
2006	-61.80%	N/A
2005	-52.40%	N/A
2004	-11.69%	N/A
2003	+5.98%	N/A
2002	-33.89%	N/A
2001	+48.28%	N/A
2000	-76.09%	N/A

AGEN vs OBIO Drawdown Comparison

The maximum drawdown for AGEN was -99.98%, occurring on Mar 31, 2025. This drawdown has not yet recovered.

The maximum drawdown for OBIO was -89.40%, occurring on Sep 23, 2025. This drawdown has not yet recovered.

The current AGEN drawdown is -99.90%. The current OBIO drawdown is -83.59%.

Rank	AGEN	OBIO
#1	-99.98% Mar 9, 2000 - Mar 31, 2025	-89.40% Apr 12, 2023 - Sep 23, 2025
#2	-23.90% Feb 16, 2000 - Mar 9, 2000	-42.60% Feb 16, 2021 - Mar 6, 2023
#3	-6.50% Feb 10, 2000 - Feb 15, 2000	-33.00% Mar 6, 2023 - Mar 31, 2023
#4	-4.86% Feb 8, 2000 - Feb 10, 2000	-14.37% Aug 6, 2020 - Dec 30, 2020
#5	N/A	-13.31% Dec 30, 2020 - Feb 8, 2021
#6	N/A	-5.52% Mar 31, 2023 - Apr 5, 2023
#7	N/A	-1.63% Apr 5, 2023 - Apr 11, 2023
#8	N/A	-0.53% Feb 8, 2021 - Feb 10, 2021