XBI vs VIS
Comparison between SPDR(R) S&P(R) BIOTECH ETF (XBI, ETF) and VANGUARD INDUSTRIALS INDEX FUND ETF SHARES (VIS, ETF).
XBI is from the Healthcare sector, while VIS is from the Industrials sector.
5-Year PerformanceVIS has outperformed XBI, delivering a return of +12.9% compared to +2.2%
XBI vs VIS - Performance Comparison
Key Characteristics
Financial metrics and valuation ratios
Net Assets
XBI
$8.30B
VIS
$8.30B
Expense Ratio
XBI
0.35%
Winner
VIS
0.09%
Max Drawdown
Winner
XBI
63.90%
VIS
64.92%
Sharpe Ratio
Winner
XBI
2.15
VIS
1.41
5Y Beta
XBI
0.97
Winner
VIS
0.96
P/E Ratio
Winner
XBI
-10.99
VIS
35.15
Forward P/E
Winner
XBI
11.62
VIS
25.49
5Y Dividends CAGR
XBI
9.74%
Winner
VIS
17.53%
5Y EPS CAGR
XBI
5.78%
Winner
VIS
11.04%
Debt to Equity
Winner
XBI
37.46%
VIS
78.92%
P/S Ratio
XBI
8.25
Winner
VIS
2.54
P/B Ratio
Winner
XBI
4.89
VIS
6.08
XBI vs VIS - Holdings Comparison
XBI and VIS have 1 common holdings. Overlap is -0.09%
XBI's top 25 holdings weight is 32.10%. VIS's top 25 holdings weight is 46.40%.
| Rank | XBI | VIS |
|---|---|---|
| #1 | APELLIS PHARMACEUTICALS INC (APLS) - 1.75% | CATERPILLAR INC (CAT) - 5.09% |
| #2 | SUMMIT THERAPEUTICS INC ORDINARY SHARES (SMMT) - 1.62% | GE AEROSPACE (GE) - 4.59% |
| #3 | REVOLUTION MEDICINES INC ORDINARY SHARES (RVMD) - 1.60% | RTX CORP (RTX) - 3.97% |
| #4 | TWIST BIOSCIENCE CORP (TWST) - 1.43% | GE VERNOVA INC (GEV) - 3.64% |
| #5 | TRAVERE THERAPEUTICS INC ORDINARY SHARES (TVTX) - 1.40% | BOEING CO (BA) - 2.39% |
| #6 | TG THERAPEUTICS INC (TGTX) - 1.38% | DEERE & CO (DE) - 2.22% |
| #7 | ERASCA INC (ERAS) - 1.34% | HONEYWELL INTERNATIONAL INC (HON) - 2.20% |
| #8 | ARROWHEAD PHARMACEUTICALS INC (ARWR) - 1.31% | UBER TECHNOLOGIES INC (UBER) - 2.18% |
| #9 | MADRIGAL PHARMACEUTICALS INC (MDGL) - 1.31% | EATON CORP PLC (ETN) - 2.13% |
| #10 | APOGEE THERAPEUTICS INC (APGE) - 1.30% | LOCKHEED MARTIN CORP (LMT) - 1.93% |
| #11 | ALKERMES PLC (ALKS) - 1.29% | UNION PACIFIC CORP (UNP) - 1.89% |
| #12 | BEAM THERAPEUTICS INC (BEAM) - 1.26% | PARKER HANNIFIN CORP (PH) - 1.73% |
| #13 | n/a (PRAX) - 1.23% | WASTE MANAGEMENT INC (WM) - 1.42% |
| #14 | SCHOLAR ROCK HOLDING CORP (SRRK) - 1.19% | NORTHROP GRUMMAN CORP (NOC) - 1.42% |
| #15 | CRISPR THERAPEUTICS AG (CRSP) - 1.19% | TRANE TECHNOLOGIES PLC CLASS A (TT) - 1.42% |
| #16 | EXELIXIS INC (EXEL) - 1.17% | VERTIV HOLDINGS CO CLASS A (VRT) - 1.40% |
| #17 | PROTAGONIST THERAPEUTICS INC (PTGX) - 1.17% | HOWMET AEROSPACE INC (HWM) - 1.35% |
| #18 | CELCUITY INC (CELC) - 1.16% | QUANTA SERVICES INC (PWR) - 1.26% |
| #19 | CG ONCOLOGY INC (CGON) - 1.16% | AUTOMATIC DATA PROCESSING INC (ADP) - 1.26% |
| #20 | PTC THERAPEUTICS INC (PTCT) - 1.15% | n/a (JCI) - 1.23% |
| #21 | KYMERA THERAPEUTICS INC ORDINARY SHARES (KYMR) - 1.15% | XPO INC (XPO) - 0.35% |
| #22 | BRIDGEBIO PHARMA INC (BBIO) - 1.14% | VERALTO CORP (VLTO) - 0.34% |
| #23 | NUVALENT INC CLASS A (NUVL) - 1.14% | EQUIFAX INC (EFX) - 0.34% |
| #24 | KRYSTAL BIOTECH INC (KRYS) - 1.14% | WOODWARD INC (WWD) - 0.33% |
| #25 | UNITED THERAPEUTICS CORP (UTHR) - 1.12% | TRS:UNION PACIFIC CORP USD 2026-AUG-31 (n/a) - 0.32% |
| Total Holdings | 157 | 351 |
XBI vs VIS - Historical Returns
Returns include dividend reinvestment.
1M
Winner
XBI
+2.88%
VIS
+1.22%
3M
Winner
XBI
+10.57%
VIS
+0.85%
6M
Winner
XBI
+21.78%
VIS
+16.76%
1Y
Winner
XBI
+75.81%
VIS
+27.78%
5Y(CAGR)
XBI
+2.20%
Winner
VIS
+12.92%
10Y(CAGR)
XBI
+10.57%
Winner
VIS
+14.26%
Max(CAGR)
Winner
XBI
+11.29%
VIS
+11.04%
XBI vs VIS - Annual Returns (2004 - 2026)
Returns include dividend reinvestment.
| Year | XBI | VIS |
|---|---|---|
| 2026 | +11.79% | +11.62% |
| 2025 | +33.70% | +18.83% |
| 2024 | -0.05% | +18.12% |
| 2023 | +9.54% | +22.19% |
| 2022 | -28.10% | -8.00% |
| 2021 | -20.55% | +23.59% |
| 2020 | +49.01% | +10.50% |
| 2019 | +30.54% | +29.54% |
| 2018 | -17.55% | -14.61% |
| 2017 | +42.81% | +20.68% |
| 2016 | -12.49% | +22.33% |
| 2015 | +12.40% | -3.34% |
| 2014 | +44.27% | +9.87% |
| 2013 | +42.97% | +38.60% |
| 2012 | +32.95% | +14.90% |
| 2011 | +3.91% | -3.14% |
| 2010 | +15.74% | +24.99% |
| 2009 | -0.82% | +17.66% |
| 2008 | -8.58% | -38.84% |
| 2007 | +30.24% | +12.73% |
| 2006 | -6.48% | +15.04% |
| 2005 | N/A | +6.29% |
| 2004 | N/A | +12.23% |
XBI vs VIS Drawdown Comparison
The maximum drawdown for XBI was -63.89%, occurring on May 11, 2022. This drawdown has not yet recovered.
The maximum drawdown for VIS was -63.49%, occurring on Mar 9, 2009. Recovery took 1308 trading sessions.
The current XBI drawdown is -21.49%. The current VIS drawdown is -1.84%.
| Rank | XBI | VIS |
|---|---|---|
| #1 | -63.89% Feb 8, 2021 - May 11, 2022 | -63.49% Oct 9, 2007 - Dec 18, 2012 |
| #2 | -49.25% Jul 17, 2015 - Jan 12, 2018 | -42.43% Feb 12, 2020 - Nov 9, 2020 |
| #3 | -37.67% Aug 14, 2008 - Apr 14, 2011 | -24.39% Sep 21, 2018 - Jul 24, 2019 |
| #4 | -35.26% Jun 20, 2018 - May 11, 2020 | -22.97% Nov 16, 2021 - Jun 29, 2023 |
| #5 | -29.06% Feb 27, 2014 - Oct 28, 2014 | -20.79% Nov 29, 2024 - Jun 27, 2025 |
| #6 | -26.72% Jul 22, 2011 - Jan 27, 2012 | -15.94% Feb 24, 2015 - Apr 27, 2016 |
| #7 | -22.71% Dec 6, 2007 - Jul 15, 2008 | -13.44% May 9, 2006 - Dec 27, 2006 |
| #8 | -21.93% Feb 27, 2006 - Aug 8, 2007 | -13.27% Aug 1, 2023 - Dec 12, 2023 |
| #9 | -15.10% Sep 21, 2012 - Jan 14, 2013 | -12.29% Mar 2, 2026 - May 6, 2026 |
| #10 | -14.51% Jan 29, 2018 - Jun 5, 2018 | -11.59% Jun 9, 2014 - Nov 6, 2014 |
| #11 | -13.70% Jul 20, 2020 - Oct 12, 2020 | -10.90% Jul 19, 2007 - Oct 5, 2007 |
| #12 | -13.36% Oct 2, 2013 - Jan 7, 2014 | -10.86% Jan 26, 2018 - Sep 18, 2018 |
| #13 | -13.21% Mar 19, 2015 - May 29, 2015 | -7.76% Jul 24, 2019 - Sep 13, 2019 |
| #14 | -11.51% Jan 21, 2014 - Feb 20, 2014 | -7.53% Mar 7, 2005 - Nov 10, 2005 |
| #15 | -10.38% May 30, 2013 - Jul 10, 2013 | -7.26% Jan 15, 2014 - Mar 4, 2014 |
Correlation
Correlation between XBI and VIS is 0.82 which considered as a strong positive correlation - the stocks tend to move together.
0.82
-101
Dividend Comparison (2004 - 2026)
XBI vs VIS dividend yield comparison.
| Year | XBI | VIS |
|---|---|---|
| 2026 | 0.00% | 0.23% |
| 2025 | 0.37% | 1.01% |
| 2024 | 0.15% | 1.23% |
| 2023 | 0.02% | 1.36% |
| 2022 | 0.00% | 1.52% |
| 2021 | 0.04% | 1.11% |
| 2020 | 0.20% | 1.38% |
| 2019 | 0.00% | 1.68% |
| 2018 | 0.28% | 1.90% |
| 2017 | 0.24% | 1.60% |
| 2016 | 0.26% | 1.81% |
| 2015 | 0.61% | 1.94% |
| 2014 | 1.07% | 1.57% |
| 2013 | 0.17% | 1.06% |
| 2012 | 0.22% | 2.09% |
| 2011 | 0.00% | 1.96% |
| 2010 | 0.00% | 1.31% |
| 2009 | 0.28% | 1.39% |
| 2008 | 1.27% | 2.59% |
| 2007 | 0.26% | 1.34% |
| 2006 | 0.00% | 1.14% |
| 2005 | 0.00% | 0.79% |
| 2004 | 0.00% | 0.58% |
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