VRTX vs COF

Comparison between Vertex Pharmaceuticals Inc (VRTX, Company) and Capital One Financial Corp (COF, Company).

VRTX is from the Healthcare sector, while COF is from the Financial Services sector.

5-Year PerformanceVRTX has outperformed COF, delivering a return of +21.4% compared to +7.4%

VRTX vs COF - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	VRTX(COMPANY)	COF(COMPANY)
Market Cap	$127B	$126B
Max Drawdown	91.77%	90.76%
Sharpe Ratio	0.52	-0.07
5Y Beta	0.49	1.41
Industry	Biotechnology	Credit Services
P/E Ratio	29.22	38.81
Forward P/E	26.11	10.16
PEG Ratio	1.85	0.22
Dividend Yield	N/A	1.40%
5Y Dividends CAGR	N/A	29.20%
5Y EPS CAGR	9.89%	-20.01%
Debt to Equity	0.00%	1.45%
Free Cash Flow Yield	2.93%	21.63%
P/S Ratio	10.35	3.48
P/B Ratio	6.53	1.10

Market Cap

Winner

VRTX

$127B

COF

$126B

Max Drawdown

VRTX

91.77%

Winner

COF

90.76%

Sharpe Ratio

Winner

VRTX

0.52

COF

-0.07

5Y Beta

Winner

VRTX

0.49

COF

1.41

Industry

VRTX

Biotechnology

COF

Credit Services

P/E Ratio

Winner

VRTX

29.22

COF

38.81

Forward P/E

VRTX

26.11

Winner

COF

10.16

PEG Ratio

VRTX

1.85

Winner

COF

0.22

Dividend Yield

VRTX

N/A

COF

1.40%

5Y Dividends CAGR

VRTX

N/A

COF

29.20%

5Y EPS CAGR

Winner

VRTX

9.89%

COF

-20.01%

Debt to Equity

Winner

VRTX

0.00%

COF

1.45%

Free Cash Flow Yield

VRTX

2.93%

Winner

COF

21.63%

P/S Ratio

VRTX

10.35

Winner

COF

3.48

P/B Ratio

VRTX

6.53

Winner

COF

1.10

VRTX vs COF - Historical Returns

Returns include dividend reinvestment.

Period	VRTX	COF
1 month	+24.22%	+11.52%
3 months	+20.36%	+13.19%
6 months	+16.79%	-16.62%
1 year	+15.54%	-4.89%
5 years(CAGR)	+21.37%	+7.37%
10 years(CAGR)	+19.66%	+14.52%
Max(CAGR)	+14.83%	+6.73%

Winner

VRTX

+24.22%

COF

+11.52%

Winner

VRTX

+20.36%

COF

+13.19%

Winner

VRTX

+16.79%

COF

-16.62%

Winner

VRTX

+15.54%

COF

-4.89%

5Y(CAGR)

Winner

VRTX

+21.37%

COF

+7.37%

10Y(CAGR)

Winner

VRTX

+19.66%

COF

+14.52%

Max(CAGR)

Winner

VRTX

+14.83%

COF

+6.73%

VRTX vs COF - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	VRTX	COF
2026	+16.79%	-16.62%
2025	+11.73%	+37.38%
2024	-2.00%	+37.21%
2023	+42.26%	+44.29%
2022	+29.77%	-36.07%
2021	-4.28%	+50.82%
2020	+7.70%	-3.33%
2019	+33.44%	+35.63%
2018	+8.37%	-22.80%
2017	+100.11%	+14.18%
2016	-40.05%	+26.27%
2015	+2.24%	-10.84%
2014	+60.91%	+8.55%
2013	+70.22%	+26.95%
2012	+30.00%	+32.91%
2011	-7.72%	-2.79%
2010	-20.82%	+9.54%
2009	+39.62%	+18.63%
2008	+31.23%	-30.32%
2007	-37.05%	-38.73%
2006	+34.12%	-11.56%
2005	+170.21%	+3.25%
2004	+0.67%	+40.03%
2003	-36.74%	+93.70%
2002	-35.41%	-43.89%
2001	-61.05%	-12.74%
2000	+281.33%	+42.79%
1999	+32.38%	-3.94%

VRTX vs COF Drawdown Comparison

The maximum drawdown for VRTX was -91.77%, occurring on Nov 11, 2003. Recovery took 3434 trading sessions.

The maximum drawdown for COF was -90.17%, occurring on Mar 6, 2009. Recovery took 2075 trading sessions.

The current COF drawdown is -19.86%.

Rank	VRTX	COF
#1	-91.77% Nov 2, 2000 - Jul 2, 2014	-90.17% Mar 10, 2006 - Jun 9, 2014
#2	-55.25% Mar 6, 2000 - Jun 16, 2000	-65.65% May 22, 2001 - Jan 22, 2004
#3	-49.10% Aug 19, 2015 - Jul 19, 2017	-60.25% Jan 22, 2020 - Jan 6, 2021
#4	-41.60% Jul 20, 2020 - Aug 15, 2022	-50.42% Aug 13, 2021 - Nov 6, 2024
#5	-29.08% Sep 28, 2000 - Oct 25, 2000	-37.70% Nov 5, 1999 - Jul 19, 2000
#6	-29.07% Nov 8, 2024 - Jul 2, 2026	-35.40% Jul 21, 2015 - Dec 7, 2016
#7	-22.82% Jul 12, 2000 - Aug 16, 2000	-33.27% Oct 5, 2000 - May 22, 2001
#8	-21.18% Sep 28, 2018 - Jan 18, 2019	-31.88% Jan 23, 2018 - Dec 9, 2019
#9	-19.52% Jan 21, 2000 - Feb 7, 2000	-31.46% Jan 6, 2026 - Mar 27, 2026
#10	-19.39% Feb 11, 2020 - Apr 6, 2020	-28.24% Feb 19, 2025 - Jun 26, 2025
#11	-17.73% Mar 12, 2018 - Jul 12, 2018	-20.45% Apr 12, 2004 - Nov 9, 2004
#12	-17.36% Jul 24, 2017 - Jan 23, 2018	-19.58% Mar 1, 2017 - Dec 4, 2017
#13	-15.45% Jan 18, 2019 - Oct 29, 2019	-16.07% Dec 31, 2004 - Jul 21, 2005
#14	-15.26% Jan 22, 2015 - Mar 16, 2015	-15.72% Aug 22, 2005 - Dec 15, 2005
#15	-14.46% Jul 11, 2014 - Sep 19, 2014	-13.17% Jul 3, 2014 - May 13, 2015