TYRA vs INVA

Comparison between Tyra Biosciences Inc (TYRA, Company) and Innoviva Inc (INVA, Company).

Both TYRA and INVA are from the Healthcare sector.

5-Year PerformanceINVA has outperformed TYRA, delivering a return of +4.8% compared to -0.8%

TYRA vs INVA - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	TYRA(COMPANY)	INVA(COMPANY)
Market Cap	$1.51B	$1.51B
Max Drawdown	83.22%	84.32%
Sharpe Ratio	1.65	0.21
5Y Beta	0.98	0.13
Industry	Biotechnology	Biotechnology
P/E Ratio	-9.68	4.35
Forward P/E	N/A	10.55
PEG Ratio	-0.33	0.01
5Y EPS CAGR	N/A	4.55%
Debt to Equity	0.00%	20.96%
Free Cash Flow Yield	-7.28%	12.53%

Market Cap

TYRA

$1.51B

Winner

INVA

$1.51B

Max Drawdown

Winner

TYRA

83.22%

INVA

84.32%

Sharpe Ratio

Winner

TYRA

1.65

INVA

0.21

5Y Beta

TYRA

0.98

Winner

INVA

0.13

Industry

TYRA

Biotechnology

INVA

Biotechnology

P/E Ratio

Winner

TYRA

-9.68

INVA

4.35

Forward P/E

TYRA

N/A

INVA

10.55

PEG Ratio

Winner

TYRA

-0.33

INVA

0.01

5Y EPS CAGR

TYRA

N/A

INVA

4.55%

Debt to Equity

Winner

TYRA

0.00%

INVA

20.96%

Free Cash Flow Yield

TYRA

-7.28%

Winner

INVA

12.53%

TYRA vs INVA - Historical Returns

Returns include dividend reinvestment.

Period	TYRA	INVA
1 month	-23.42%	-6.57%
3 months	-30.86%	-10.33%
6 months	-10.61%	-8.59%
1 year	+132.74%	+0.68%
5 years(CAGR)	-0.78%	+4.83%
10 years(CAGR)	N/A	+5.23%
Max(CAGR)	-0.78%	+1.96%

TYRA

-23.42%

Winner

INVA

-6.57%

TYRA

-30.86%

Winner

INVA

-10.33%

TYRA

-10.61%

Winner

INVA

-8.59%

Winner

TYRA

+132.74%

INVA

+0.68%

5Y(CAGR)

TYRA

-0.78%

Winner

INVA

+4.83%

10Y(CAGR)

TYRA

N/A

INVA

+5.23%

Max(CAGR)

TYRA

-0.78%

Winner

INVA

+1.96%

TYRA vs INVA - Annual Returns (2004 - 2026)

Returns include dividend reinvestment.

Year	TYRA	INVA
2026	-6.61%	+4.43%
2025	+82.19%	+14.89%
2024	-1.00%	+5.99%
2023	+95.90%	+20.87%
2022	-46.06%	-24.07%
2021	-45.88%	+38.22%
2020	N/A	-11.06%
2019	N/A	-18.15%
2018	N/A	+20.93%
2017	N/A	+27.38%
2016	N/A	+3.68%
2015	N/A	-20.54%
2014	N/A	-50.22%
2013	N/A	+58.87%
2012	N/A	+8.49%
2011	N/A	-13.91%
2010	N/A	+87.93%
2009	N/A	-7.50%
2008	N/A	-36.30%
2007	N/A	-37.82%
2006	N/A	+39.21%
2005	N/A	+26.87%
2004	N/A	-1.16%

TYRA vs INVA Drawdown Comparison

The maximum drawdown for TYRA was -83.22%, occurring on Jun 17, 2022. Recovery took 1058 trading sessions.

The maximum drawdown for INVA was -84.32%, occurring on Nov 21, 2008. Recovery took 1504 trading sessions.

The current TYRA drawdown is -36.83%. The current INVA drawdown is -35.02%.

Rank	TYRA	INVA
#1	-83.22% Nov 4, 2021 - Jan 27, 2026	-84.32% May 22, 2007 - May 13, 2013
#2	-48.23% Sep 15, 2021 - Nov 3, 2021	-78.77% Jul 11, 2013 - Sep 29, 2015
#3	-36.83% Apr 2, 2026 - Aug 13, 2026	-26.22% Apr 5, 2006 - Oct 19, 2006
#4	-13.45% Jan 29, 2026 - Feb 23, 2026	-21.77% Feb 8, 2007 - May 22, 2007
#5	-9.38% Mar 19, 2026 - Mar 31, 2026	-20.78% May 14, 2013 - Jul 11, 2013
#6	-5.74% Feb 25, 2026 - Mar 4, 2026	-16.58% Oct 21, 2004 - Mar 8, 2005
#7	-4.31% Mar 4, 2026 - Mar 11, 2026	-13.06% Oct 25, 2005 - Jan 17, 2006
#8	-1.48% Mar 11, 2026 - Mar 16, 2026	-12.25% Mar 8, 2005 - Jul 25, 2005
#9	-1.02% Jan 27, 2026 - Jan 29, 2026	-10.48% Feb 9, 2006 - Apr 5, 2006
#10	-0.05% Mar 31, 2026 - Apr 2, 2026	-8.88% Oct 27, 2006 - Jan 12, 2007
#11	N/A	-5.70% Oct 7, 2004 - Oct 21, 2004
#12	N/A	-5.63% Aug 1, 2005 - Sep 15, 2005
#13	N/A	-5.52% Jan 16, 2007 - Feb 7, 2007
#14	N/A	-4.40% Sep 20, 2005 - Oct 14, 2005
#15	N/A	-2.38% Feb 2, 2006 - Feb 8, 2006