TYRA vs APPN

Comparison between Tyra Biosciences Inc (TYRA, Company) and Appian Corp - Class A (APPN, Company).

TYRA is from the Healthcare sector, while APPN is from the Technology sector.

5-Year PerformanceTYRA has outperformed APPN, delivering a return of +3.5% compared to -28.9%

TYRA vs APPN - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	TYRA(COMPANY)	APPN(COMPANY)
Market Cap	$1.75B	$1.75B
Max Drawdown	83.22%	92.04%
Sharpe Ratio	2.14	-0.14
5Y Beta	1.04	1.04
Industry	Biotechnology	Software - Infrastructure
P/E Ratio	-12.36	364.53
Forward P/E	N/A	416.67
PEG Ratio	-0.43	0.00
Debt to Equity	0.00%	-404.34%
Free Cash Flow Yield	-5.86%	3.66%
P/S Ratio	N/A	2.29
P/B Ratio	4.51	42.82

Market Cap

Winner

TYRA

$1.75B

APPN

$1.75B

Max Drawdown

Winner

TYRA

83.22%

APPN

92.04%

Sharpe Ratio

Winner

TYRA

2.14

APPN

-0.14

5Y Beta

TYRA

1.04

Winner

APPN

1.04

Industry

TYRA

Biotechnology

APPN

Software - Infrastructure

P/E Ratio

Winner

TYRA

-12.36

APPN

364.53

Forward P/E

TYRA

N/A

APPN

416.67

PEG Ratio

Winner

TYRA

-0.43

APPN

0.00

Debt to Equity

TYRA

0.00%

Winner

APPN

-404.34%

Free Cash Flow Yield

TYRA

-5.86%

Winner

APPN

3.66%

P/S Ratio

TYRA

N/A

APPN

2.29

P/B Ratio

Winner

TYRA

4.51

APPN

42.82

TYRA vs APPN - Historical Returns

Returns include dividend reinvestment.

Period	TYRA	APPN
1 month	+6.84%	-8.58%
3 months	-22.70%	-0.29%
6 months	+14.30%	-28.36%
1 year	+204.68%	-19.04%
5 years(CAGR)	+3.47%	-28.89%
10 years(CAGR)	N/A	+5.48%
Max(CAGR)	+3.47%	+5.48%

Winner

TYRA

+6.84%

APPN

-8.58%

TYRA

-22.70%

Winner

APPN

-0.29%

Winner

TYRA

+14.30%

APPN

-28.36%

Winner

TYRA

+204.68%

APPN

-19.04%

5Y(CAGR)

Winner

TYRA

+3.47%

APPN

-28.89%

10Y(CAGR)

TYRA

N/A

APPN

+5.48%

Max(CAGR)

TYRA

+3.47%

Winner

APPN

+5.48%

TYRA vs APPN - Annual Returns (2017 - 2026)

Returns include dividend reinvestment.

Year	TYRA	APPN
2026	+14.30%	-28.36%
2025	+82.19%	+6.72%
2024	-1.00%	-6.15%
2023	+95.90%	+16.23%
2022	-46.06%	-50.55%
2021	-45.88%	-54.62%
2020	N/A	+317.97%
2019	N/A	+44.19%
2018	N/A	-19.21%
2017	N/A	+109.73%

TYRA vs APPN Drawdown Comparison

The maximum drawdown for TYRA was -83.22%, occurring on Jun 17, 2022. Recovery took 1058 trading sessions.

The maximum drawdown for APPN was -92.04%, occurring on May 13, 2026. This drawdown has not yet recovered.

The current TYRA drawdown is -22.70%. The current APPN drawdown is -89.63%.

Rank	TYRA	APPN
#1	-83.22% Nov 4, 2021 - Jan 27, 2026	-92.04% Jan 27, 2021 - May 13, 2026
#2	-48.23% Sep 15, 2021 - Nov 3, 2021	-50.46% Feb 18, 2020 - Sep 29, 2020
#3	-35.82% Apr 2, 2026 - Jun 10, 2026	-46.61% Jun 18, 2018 - Aug 8, 2019
#4	-13.45% Jan 29, 2026 - Feb 23, 2026	-38.63% Aug 26, 2019 - Feb 18, 2020
#5	-9.38% Mar 19, 2026 - Mar 31, 2026	-37.05% Jan 5, 2018 - Jun 14, 2018
#6	-5.74% Feb 25, 2026 - Mar 4, 2026	-30.82% Sep 29, 2017 - Dec 26, 2017
#7	-4.31% Mar 4, 2026 - Mar 11, 2026	-29.72% Nov 27, 2020 - Jan 22, 2021
#8	-1.48% Mar 11, 2026 - Mar 16, 2026	-24.44% Oct 14, 2020 - Nov 6, 2020
#9	-1.02% Jan 27, 2026 - Jan 29, 2026	-17.57% Sep 11, 2017 - Sep 29, 2017
#10	-0.05% Mar 31, 2026 - Apr 2, 2026	-13.07% Jun 5, 2017 - Jul 12, 2017
#11	N/A	-10.81% Aug 8, 2017 - Aug 28, 2017
#12	N/A	-8.47% Jan 22, 2021 - Jan 26, 2021
#13	N/A	-8.06% Jul 20, 2017 - Aug 7, 2017
#14	N/A	-6.78% Nov 10, 2020 - Nov 13, 2020
#15	N/A	-6.31% Dec 28, 2017 - Jan 3, 2018