TXG vs SPY

Comparison between 10x Genomics Inc - Class A (TXG, Company) and SPDR S&P 500 ETF Trust (SPY, ETF).

5-Year PerformanceSPY has outperformed TXG, delivering a return of +13.9% compared to -32.0%

TXG vs SPY - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	TXG(COMPANY)	SPY(ETF)
Market Cap / Net Assets	$3.08B	$735B
Expense Ratio	N/A	0.09%
Max Drawdown	96.47%	56.47%
Sharpe Ratio	1.90	1.96
5Y Beta	1.96	1.00
Industry	Health Information Services	N/A
P/E Ratio	-73.78	28.62
Forward P/E	400.00	22.09
5Y Dividends CAGR	N/A	5.43%
5Y EPS CAGR	N/A	26.35%
Debt to Equity	0.00%	33.33%
Free Cash Flow Yield	3.97%	N/A
P/S Ratio	4.77	3.68
P/B Ratio	3.74	5.52

Market Cap / Net Assets

TXG

$3.08B

Winner

SPY

$735B

Expense Ratio

TXG

N/A

SPY

0.09%

Max Drawdown

TXG

96.47%

Winner

SPY

56.47%

Sharpe Ratio

TXG

1.90

Winner

SPY

1.96

5Y Beta

TXG

1.96

Winner

SPY

1.00

Industry

TXG

Health Information Services

SPY

N/A

P/E Ratio

Winner

TXG

-73.78

SPY

28.62

Forward P/E

TXG

400.00

Winner

SPY

22.09

5Y Dividends CAGR

TXG

N/A

SPY

5.43%

5Y EPS CAGR

TXG

N/A

SPY

26.35%

Debt to Equity

Winner

TXG

0.00%

SPY

33.33%

Free Cash Flow Yield

TXG

3.97%

SPY

N/A

P/S Ratio

TXG

4.77

Winner

SPY

3.68

P/B Ratio

Winner

TXG

3.74

SPY

5.52

TXG vs SPY - Historical Returns

Returns include dividend reinvestment.

Period	TXG	SPY
1 month	+10.50%	+4.95%
3 months	+11.25%	+9.19%
6 months	+31.31%	+11.06%
1 year	+186.61%	+28.43%
5 years(CAGR)	-32.01%	+13.92%
10 years(CAGR)	N/A	+15.50%
Max(CAGR)	-10.75%	+8.55%

Winner

TXG

+10.50%

SPY

+4.95%

Winner

TXG

+11.25%

SPY

+9.19%

Winner

TXG

+31.31%

SPY

+11.06%

Winner

TXG

+186.61%

SPY

+28.43%

5Y(CAGR)

TXG

-32.01%

Winner

SPY

+13.92%

10Y(CAGR)

TXG

N/A

SPY

+15.50%

Max(CAGR)

TXG

-10.75%

Winner

SPY

+8.55%

TXG vs SPY - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	TXG	SPY
2026	+48.13%	+10.17%
2025	+14.94%	+18.00%
2024	-73.55%	+25.59%
2023	+58.39%	+26.72%
2022	-75.01%	-18.64%
2021	+5.98%	+30.52%
2020	+94.43%	+17.28%
2019	+44.55%	+31.09%
2018	N/A	-5.24%
2017	N/A	+20.78%
2016	N/A	+13.59%
2015	N/A	+1.31%
2014	N/A	+14.56%
2013	N/A	+29.00%
2012	N/A	+14.17%
2011	N/A	+0.85%
2010	N/A	+13.14%
2009	N/A	+22.67%
2008	N/A	-36.25%
2007	N/A	+5.32%
2006	N/A	+13.85%
2005	N/A	+5.32%
2004	N/A	+10.75%
2003	N/A	+24.18%
2002	N/A	-22.42%
2001	N/A	-10.13%
2000	N/A	-8.84%
1999	N/A	+8.61%

TXG vs SPY Drawdown Comparison

The maximum drawdown for TXG was -96.47%, occurring on Apr 8, 2025. This drawdown has not yet recovered.

The maximum drawdown for SPY was -55.20%, occurring on Mar 9, 2009. Recovery took 1224 trading sessions.

The current TXG drawdown is -87.83%.

Rank	TXG	SPY
#1	-96.47% Apr 26, 2021 - Apr 8, 2025	-55.20% Oct 9, 2007 - Aug 16, 2012
#2	-51.63% Jan 28, 2020 - Aug 19, 2020	-47.50% Mar 24, 2000 - Oct 26, 2006
#3	-28.33% Feb 12, 2021 - Apr 6, 2021	-33.70% Feb 19, 2020 - Aug 10, 2020
#4	-25.69% Sep 18, 2019 - Nov 14, 2019	-24.50% Jan 3, 2022 - Dec 13, 2023
#5	-21.20% Oct 16, 2020 - Jan 11, 2021	-19.34% Sep 20, 2018 - Apr 12, 2019
#6	-12.72% Jan 22, 2021 - Feb 11, 2021	-18.76% Feb 19, 2025 - Jun 26, 2025
#7	-11.45% Dec 18, 2019 - Dec 20, 2019	-13.02% Jul 20, 2015 - Apr 18, 2016
#8	-10.14% Nov 15, 2019 - Dec 18, 2019	-10.10% Jan 26, 2018 - Aug 6, 2018
#9	-8.44% Dec 23, 2019 - Jan 10, 2020	-9.44% Sep 2, 2020 - Nov 11, 2020
#10	-8.42% Apr 13, 2021 - Apr 26, 2021	-9.30% Jan 19, 2000 - Mar 17, 2000
#11	-7.23% Aug 31, 2020 - Sep 11, 2020	-9.05% Jul 19, 2007 - Oct 5, 2007
#12	-6.03% Apr 6, 2021 - Apr 13, 2021	-8.88% Jan 27, 2026 - Apr 14, 2026
#13	-4.97% Sep 11, 2020 - Oct 1, 2020	-8.41% Jul 16, 2024 - Sep 19, 2024
#14	-3.47% Aug 21, 2020 - Aug 26, 2020	-7.35% Sep 14, 2012 - Jan 2, 2013
#15	-2.63% Jan 16, 2020 - Jan 21, 2020	-7.27% Sep 18, 2014 - Oct 31, 2014

Correlation

Correlation between TXG and SPY is -0.54 which considered as a moderate negative correlation - the stocks show some tendency to move in opposite directions.

-0.54

-101