TSHA vs SNDX

Comparison between Taysha Gene Therapies Inc (TSHA, Company) and Syndax Pharmaceuticals Inc (SNDX, Company).

Both TSHA and SNDX are from the Healthcare sector.

5-Year PerformanceSNDX has outperformed TSHA, delivering a return of -0.5% compared to -25.3%

TSHA vs SNDX - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	TSHA(COMPANY)	SNDX(COMPANY)
Market Cap	$1.55B	$1.56B
Max Drawdown	98.14%	78.98%
Sharpe Ratio	1.22	1.03
5Y Beta	1.40	1.06
Industry	Biotechnology	Biotechnology
P/E Ratio	-11.65	-6.29
PEG Ratio	-1.29	0.00
5Y EPS CAGR	N/A	12.13%
Debt to Equity	23.10%	840.90%
Free Cash Flow Yield	-7.27%	-17.88%
P/S Ratio	207.70	7.21
P/B Ratio	7.32	37.64

Market Cap

TSHA

$1.55B

Winner

SNDX

$1.56B

Max Drawdown

TSHA

98.14%

Winner

SNDX

78.98%

Sharpe Ratio

Winner

TSHA

1.22

SNDX

1.03

5Y Beta

TSHA

1.40

Winner

SNDX

1.06

Industry

TSHA

Biotechnology

SNDX

Biotechnology

P/E Ratio

Winner

TSHA

-11.65

SNDX

-6.29

PEG Ratio

Winner

TSHA

-1.29

SNDX

0.00

5Y EPS CAGR

TSHA

N/A

SNDX

12.13%

Debt to Equity

Winner

TSHA

23.10%

SNDX

840.90%

Free Cash Flow Yield

Winner

TSHA

-7.27%

SNDX

-17.88%

P/S Ratio

TSHA

207.70

Winner

SNDX

7.21

P/B Ratio

Winner

TSHA

7.32

SNDX

37.64

TSHA vs SNDX - Historical Returns

Returns include dividend reinvestment.

Period	TSHA	SNDX
1 month	-16.64%	-10.58%
3 months	+23.86%	-23.93%
6 months	-1.38%	-10.41%
1 year	+115.47%	+71.04%
5 years(CAGR)	-25.27%	-0.55%
10 years(CAGR)	N/A	+3.47%
Max(CAGR)	-22.25%	+4.16%

TSHA

-16.64%

Winner

SNDX

-10.58%

Winner

TSHA

+23.86%

SNDX

-23.93%

Winner

TSHA

-1.38%

SNDX

-10.41%

Winner

TSHA

+115.47%

SNDX

+71.04%

5Y(CAGR)

TSHA

-25.27%

Winner

SNDX

-0.55%

10Y(CAGR)

TSHA

N/A

SNDX

+3.47%

Max(CAGR)

TSHA

-22.25%

Winner

SNDX

+4.16%

TSHA vs SNDX - Annual Returns (2016 - 2026)

Returns include dividend reinvestment.

Year	TSHA	SNDX
2026	+8.76%	-14.32%
2025	+197.30%	+49.22%
2024	+1.17%	-39.52%
2023	-19.55%	-15.59%
2022	-80.94%	+14.90%
2021	-55.48%	-2.01%
2020	+10.31%	+153.59%
2019	N/A	+97.30%
2018	N/A	-49.26%
2017	N/A	+19.67%
2016	N/A	-40.30%

TSHA vs SNDX Drawdown Comparison

The maximum drawdown for TSHA was -98.14%, occurring on Jun 28, 2023. This drawdown has not yet recovered.

The maximum drawdown for SNDX was -78.98%, occurring on Dec 24, 2018. Recovery took 925 trading sessions.

The current TSHA drawdown is -82.02%. The current SNDX drawdown is -37.03%.

Rank	TSHA	SNDX
#1	-98.14% Jan 20, 2021 - Jun 28, 2023	-78.98% Aug 23, 2016 - Apr 28, 2020
#2	-21.78% Sep 25, 2020 - Dec 23, 2020	-69.88% Feb 1, 2023 - Jul 7, 2025
#3	-10.74% Dec 23, 2020 - Jan 14, 2021	-49.24% Dec 21, 2020 - Jan 12, 2023
#4	N/A	-45.42% Apr 6, 2016 - Aug 23, 2016
#5	N/A	-36.18% May 15, 2020 - Nov 5, 2020
#6	N/A	-24.21% Mar 9, 2016 - Apr 5, 2016
#7	N/A	-12.36% Nov 5, 2020 - Nov 16, 2020
#8	N/A	-8.41% Mar 3, 2016 - Mar 8, 2016
#9	N/A	-7.69% Apr 28, 2020 - May 15, 2020
#10	N/A	-5.68% Dec 15, 2020 - Dec 21, 2020
#11	N/A	-5.59% Dec 9, 2020 - Dec 15, 2020
#12	N/A	-5.40% Dec 7, 2020 - Dec 9, 2020
#13	N/A	-4.38% Jan 26, 2023 - Jan 31, 2023
#14	N/A	-3.60% Nov 20, 2020 - Nov 25, 2020
#15	N/A	-3.46% Jan 12, 2023 - Jan 24, 2023