SYRE vs YOU

Comparison between Spyre Therapeutics Inc (SYRE, Company) and Clear Secure Inc Class A (YOU, Company).

SYRE is from the Healthcare sector, while YOU is from the Technology sector.

5-Year PerformanceYOU has outperformed SYRE, delivering a return of +9.1% compared to -14.8%

SYRE vs YOU - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SYRE(COMPANY)	YOU(COMPANY)
Market Cap	$5.72B	$5.71B
Max Drawdown	99.11%	73.41%
Sharpe Ratio	2.47	1.49
5Y Beta	1.74	0.85
Industry	Biotechnology	Software - Application
P/E Ratio	-29.38	45.25
Dividend Yield	N/A	0.94%
5Y EPS CAGR	-2.15%	19.15%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-3.25%	7.65%
P/S Ratio	650.22	8.04
P/B Ratio	12.16	30.84

Market Cap

Winner

SYRE

$5.72B

YOU

$5.71B

Max Drawdown

SYRE

99.11%

Winner

YOU

73.41%

Sharpe Ratio

Winner

SYRE

2.47

YOU

1.49

5Y Beta

SYRE

1.74

Winner

YOU

0.85

Industry

SYRE

Biotechnology

YOU

Software - Application

P/E Ratio

Winner

SYRE

-29.38

YOU

45.25

Dividend Yield

SYRE

N/A

YOU

0.94%

5Y EPS CAGR

SYRE

-2.15%

Winner

YOU

19.15%

Debt to Equity

SYRE

0.00%

YOU

0.00%

Free Cash Flow Yield

SYRE

-3.25%

Winner

YOU

7.65%

P/S Ratio

SYRE

650.22

Winner

YOU

8.04

P/B Ratio

Winner

SYRE

12.16

YOU

30.84

SYRE vs YOU - Historical Returns

Returns include dividend reinvestment.

Period	SYRE	YOU
1 month	+3.72%	-7.23%
3 months	+81.45%	+15.85%
6 months	+120.18%	+64.56%
1 year	+343.14%	+114.11%
5 years(CAGR)	-14.82%	+9.06%
10 years(CAGR)	-9.03%	N/A
Max(CAGR)	-11.13%	+9.06%

Winner

SYRE

+3.72%

YOU

-7.23%

Winner

SYRE

+81.45%

YOU

+15.85%

Winner

SYRE

+120.18%

YOU

+64.56%

Winner

SYRE

+343.14%

YOU

+114.11%

5Y(CAGR)

SYRE

-14.82%

Winner

YOU

+9.06%

10Y(CAGR)

SYRE

-9.03%

YOU

N/A

Max(CAGR)

SYRE

-11.13%

Winner

YOU

+9.06%

SYRE vs YOU - Annual Returns (2016 - 2026)

Returns include dividend reinvestment.

Year	SYRE	YOU
2026	+140.84%	+59.79%
2025	+37.36%	+33.31%
2024	+8.79%	+34.72%
2023	+104.27%	-22.67%
2022	-90.57%	-13.21%
2021	-44.51%	-21.57%
2020	+1.55%	N/A
2019	-4.98%	N/A
2018	+39.22%	N/A
2017	+18.38%	N/A
2016	-55.48%	N/A

SYRE vs YOU Drawdown Comparison

The maximum drawdown for SYRE was -99.11%, occurring on Jun 21, 2023. This drawdown has not yet recovered.

The maximum drawdown for YOU was -72.92%, occurring on Oct 30, 2023. Recovery took 1183 trading sessions.

The current SYRE drawdown is -75.43%. The current YOU drawdown is -12.57%.

Rank	SYRE	YOU
#1	-99.11% Apr 8, 2016 - Jun 21, 2023	-72.92% Aug 2, 2021 - Apr 20, 2026
#2	N/A	-18.33% Jul 2, 2021 - Jul 30, 2021
#3	N/A	-12.64% May 26, 2026 - Jun 4, 2026
#4	N/A	-8.86% May 6, 2026 - May 20, 2026
#5	N/A	-8.67% Apr 21, 2026 - May 5, 2026
#6	N/A	-3.14% May 20, 2026 - May 26, 2026