SYRE vs COLB

Comparison between Spyre Therapeutics Inc (SYRE, Company) and Columbia Banking System Inc (COLB, Company).

SYRE is from the Healthcare sector, while COLB is from the Financial Services sector.

5-Year PerformanceCOLB has outperformed SYRE, delivering a return of +2.4% compared to -7.5%

SYRE vs COLB - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SYRE(COMPANY)	COLB(COMPANY)
Market Cap	$9.17B	$9.12B
Max Drawdown	99.11%	86.81%
Sharpe Ratio	3.05	1.19
5Y Beta	1.79	1.14
Industry	Biotechnology	Banks - Regional
P/E Ratio	-45.84	13.18
Forward P/E	N/A	10.25
PEG Ratio	N/A	5.56
Dividend Yield	N/A	4.70%
5Y Dividends CAGR	N/A	10.32%
5Y EPS CAGR	-2.73%	-2.54%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-2.28%	14.32%

Market Cap

Winner

SYRE

$9.17B

COLB

$9.12B

Max Drawdown

SYRE

99.11%

Winner

COLB

86.81%

Sharpe Ratio

Winner

SYRE

3.05

COLB

1.19

5Y Beta

SYRE

1.79

Winner

COLB

1.14

Industry

SYRE

Biotechnology

COLB

Banks - Regional

P/E Ratio

Winner

SYRE

-45.84

COLB

13.18

Forward P/E

SYRE

N/A

COLB

10.25

PEG Ratio

SYRE

N/A

COLB

5.56

Dividend Yield

SYRE

N/A

COLB

4.70%

5Y Dividends CAGR

SYRE

N/A

COLB

10.32%

5Y EPS CAGR

SYRE

-2.73%

Winner

COLB

-2.54%

Debt to Equity

SYRE

0.00%

COLB

0.00%

Free Cash Flow Yield

SYRE

-2.28%

Winner

COLB

14.32%

SYRE vs COLB - Historical Returns

Returns include dividend reinvestment.

Period	SYRE	COLB
1 month	+8.66%	+1.44%
3 months	+33.47%	+14.40%
6 months	+178.05%	+5.66%
1 year	+485.34%	+30.77%
5 years(CAGR)	-7.54%	+2.35%
10 years(CAGR)	-1.21%	+4.42%
Max(CAGR)	-8.10%	+6.81%

Winner

SYRE

+8.66%

COLB

+1.44%

Winner

SYRE

+33.47%

COLB

+14.40%

Winner

SYRE

+178.05%

COLB

+5.66%

Winner

SYRE

+485.34%

COLB

+30.77%

5Y(CAGR)

SYRE

-7.54%

Winner

COLB

+2.35%

10Y(CAGR)

SYRE

-1.21%

Winner

COLB

+4.42%

Max(CAGR)

SYRE

-8.10%

Winner

COLB

+6.81%

SYRE vs COLB - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	SYRE	COLB
2026	+233.06%	+18.03%
2025	+37.36%	+9.97%
2024	+8.79%	+8.38%
2023	+104.27%	-3.10%
2022	-90.57%	-6.25%
2021	-44.51%	-4.16%
2020	+1.55%	-8.19%
2019	-4.98%	+13.95%
2018	+39.22%	-14.37%
2017	+18.38%	-0.31%
2016	-55.48%	+47.89%
2015	N/A	+23.24%
2014	N/A	+4.20%
2013	N/A	+49.96%
2012	N/A	-5.65%
2011	N/A	-9.53%
2010	N/A	+27.06%
2009	N/A	+37.91%
2008	N/A	-57.72%
2007	N/A	-12.36%
2006	N/A	+21.87%
2005	N/A	+17.16%
2004	N/A	+21.34%
2003	N/A	+69.18%
2002	N/A	-0.27%
2001	N/A	-4.30%
2000	N/A	+20.25%
1999	N/A	-3.67%

SYRE vs COLB Drawdown Comparison

The maximum drawdown for SYRE was -99.11%, occurring on Jun 21, 2023. This drawdown has not yet recovered.

The maximum drawdown for COLB was -85.93%, occurring on Mar 9, 2009. Recovery took 2236 trading sessions.

The current SYRE drawdown is -66.02%. The current COLB drawdown is -15.97%.

Rank	SYRE	COLB
#1	-99.11% Apr 8, 2016 - Jun 21, 2023	-85.93% Jun 30, 2006 - May 20, 2015
#2	N/A	-60.76% Mar 12, 2021 - May 12, 2023
#3	N/A	-53.60% Dec 4, 2017 - Feb 8, 2021
#4	N/A	-36.63% Nov 30, 1999 - Mar 17, 2003
#5	N/A	-24.14% Nov 11, 2015 - Nov 9, 2016
#6	N/A	-23.02% Mar 31, 2004 - Dec 28, 2004
#7	N/A	-19.21% Dec 27, 2016 - Nov 2, 2017
#8	N/A	-15.73% Jul 28, 2005 - Oct 31, 2005
#9	N/A	-14.85% Dec 28, 2004 - Jul 20, 2005
#10	N/A	-14.11% Aug 17, 2015 - Oct 28, 2015
#11	N/A	-8.58% Apr 19, 2006 - Jun 29, 2006
#12	N/A	-8.02% Feb 24, 2021 - Mar 8, 2021
#13	N/A	-7.94% Jul 14, 2003 - Sep 19, 2003
#14	N/A	-7.16% Sep 22, 2003 - Oct 7, 2003
#15	N/A	-6.86% Oct 14, 2003 - Nov 5, 2003