SYRE vs AVTR

Comparison between Spyre Therapeutics Inc (SYRE, Company) and Avantor Inc (AVTR, Company).

Both SYRE and AVTR are from the Healthcare sector.

5-Year PerformanceSYRE has outperformed AVTR, delivering a return of -14.8% compared to -21.8%

SYRE vs AVTR - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SYRE(COMPANY)	AVTR(COMPANY)
Market Cap	$5.72B	$5.73B
Max Drawdown	99.11%	83.16%
Sharpe Ratio	2.47	-0.54
5Y Beta	1.74	1.07
Industry	Biotechnology	Medical Instruments & Supplies
P/E Ratio	-29.38	-10.37
Forward P/E	N/A	12.36
5Y EPS CAGR	-2.15%	N/A
Debt to Equity	0.00%	68.29%
Free Cash Flow Yield	-3.25%	7.66%
P/S Ratio	650.22	0.95
P/B Ratio	12.16	1.12

Market Cap

SYRE

$5.72B

Winner

AVTR

$5.73B

Max Drawdown

SYRE

99.11%

Winner

AVTR

83.16%

Sharpe Ratio

Winner

SYRE

2.47

AVTR

-0.54

5Y Beta

SYRE

1.74

Winner

AVTR

1.07

Industry

SYRE

Biotechnology

AVTR

Medical Instruments & Supplies

P/E Ratio

Winner

SYRE

-29.38

AVTR

-10.37

Forward P/E

SYRE

N/A

AVTR

12.36

5Y EPS CAGR

SYRE

-2.15%

AVTR

N/A

Debt to Equity

Winner

SYRE

0.00%

AVTR

68.29%

Free Cash Flow Yield

SYRE

-3.25%

Winner

AVTR

7.66%

P/S Ratio

SYRE

650.22

Winner

AVTR

0.95

P/B Ratio

SYRE

12.16

Winner

AVTR

1.12

SYRE vs AVTR - Historical Returns

Returns include dividend reinvestment.

Period	SYRE	AVTR
1 month	+3.72%	+13.66%
3 months	+81.45%	+7.39%
6 months	+120.18%	-16.29%
1 year	+343.14%	-29.34%
5 years(CAGR)	-14.82%	-21.80%
10 years(CAGR)	-9.03%	N/A
Max(CAGR)	-11.13%	-6.32%

SYRE

+3.72%

Winner

AVTR

+13.66%

Winner

SYRE

+81.45%

AVTR

+7.39%

Winner

SYRE

+120.18%

AVTR

-16.29%

Winner

SYRE

+343.14%

AVTR

-29.34%

5Y(CAGR)

Winner

SYRE

-14.82%

AVTR

-21.80%

10Y(CAGR)

SYRE

-9.03%

AVTR

N/A

Max(CAGR)

SYRE

-11.13%

Winner

AVTR

-6.32%

SYRE vs AVTR - Annual Returns (2016 - 2026)

Returns include dividend reinvestment.

Year	SYRE	AVTR
2026	+140.84%	-20.16%
2025	+37.36%	-45.94%
2024	+8.79%	-7.38%
2023	+104.27%	+7.84%
2022	-90.57%	-48.00%
2021	-44.51%	+54.30%
2020	+1.55%	+52.57%
2019	-4.98%	+25.17%
2018	+39.22%	N/A
2017	+18.38%	N/A
2016	-55.48%	N/A

SYRE vs AVTR Drawdown Comparison

The maximum drawdown for SYRE was -99.11%, occurring on Jun 21, 2023. This drawdown has not yet recovered.

The maximum drawdown for AVTR was -83.16%, occurring on Mar 27, 2026. This drawdown has not yet recovered.

The current SYRE drawdown is -75.43%. The current AVTR drawdown is -79.21%.

Rank	SYRE	AVTR
#1	-99.11% Apr 8, 2016 - Jun 21, 2023	-83.16% Sep 24, 2021 - Mar 27, 2026
#2	N/A	-57.02% Feb 6, 2020 - Jul 27, 2020
#3	N/A	-28.94% Jul 5, 2019 - Jan 17, 2020
#4	N/A	-12.58% Jan 25, 2021 - Apr 6, 2021
#5	N/A	-9.91% Apr 26, 2021 - Jun 10, 2021
#6	N/A	-9.63% Oct 22, 2020 - Nov 6, 2020
#7	N/A	-9.37% Aug 3, 2020 - Aug 31, 2020
#8	N/A	-6.60% Aug 31, 2020 - Sep 16, 2020
#9	N/A	-6.16% Nov 17, 2020 - Dec 31, 2020
#10	N/A	-5.84% Jan 11, 2021 - Jan 22, 2021
#11	N/A	-5.66% Sep 21, 2020 - Oct 1, 2020
#12	N/A	-5.00% Jan 17, 2020 - Feb 6, 2020
#13	N/A	-4.16% Apr 12, 2021 - Apr 23, 2021
#14	N/A	-3.67% May 28, 2019 - Jun 12, 2019
#15	N/A	-3.66% Oct 12, 2020 - Oct 20, 2020