SPRO vs DH

Comparison between Spero Therapeutics Inc (SPRO, Company) and Definitive Healthcare Corp - Class A (DH, Company).

Both SPRO and DH are from the Healthcare sector.

5-Year PerformanceSPRO has outperformed DH, delivering a return of -39.5% compared to -57.4%

SPRO vs DH - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SPRO(COMPANY)	DH(COMPANY)
Market Cap	$74M	$73M
Max Drawdown	97.46%	98.72%
Sharpe Ratio	-0.84	-2.13
5Y Beta	0.67	1.02
Industry	Biotechnology	Health Information Services
P/E Ratio	4.65	-0.28
Forward P/E	N/A	4.24
PEG Ratio	0.00	N/A
5Y Dividends CAGR	30.26%	N/A
Debt to Equity	0.00%	85.34%
Free Cash Flow Yield	9.85%	36.88%
P/S Ratio	1.20	0.31
P/B Ratio	1.50	0.52

Market Cap

Winner

SPRO

$74M

$73M

Max Drawdown

Winner

SPRO

97.46%

98.72%

Sharpe Ratio

Winner

SPRO

-0.84

-2.13

5Y Beta

Winner

SPRO

0.67

1.02

Industry

SPRO

Biotechnology

Health Information Services

P/E Ratio

SPRO

4.65

Winner

-0.28

Forward P/E

SPRO

N/A

4.24

PEG Ratio

SPRO

0.00

N/A

5Y Dividends CAGR

SPRO

30.26%

N/A

Debt to Equity

Winner

SPRO

0.00%

85.34%

Free Cash Flow Yield

SPRO

9.85%

Winner

36.88%

P/S Ratio

SPRO

1.20

Winner

0.31

P/B Ratio

SPRO

1.50

Winner

0.52

SPRO vs DH - Historical Returns

Returns include dividend reinvestment.

Period	SPRO	DH
1 month	-46.05%	-6.96%
3 months	-58.57%	-31.40%
6 months	-52.46%	-71.77%
1 year	-51.26%	-83.82%
5 years(CAGR)	-39.52%	-57.44%
10 years(CAGR)	-10.05%	N/A
Max(CAGR)	-4.36%	-57.44%

SPRO

-46.05%

Winner

-6.96%

SPRO

-58.57%

Winner

-31.40%

Winner

SPRO

-52.46%

-71.77%

Winner

SPRO

-51.26%

-83.82%

5Y(CAGR)

Winner

SPRO

-39.52%

-57.44%

10Y(CAGR)

SPRO

-10.05%

N/A

Max(CAGR)

Winner

SPRO

-4.36%

-57.44%

SPRO vs DH - Annual Returns (2004 - 2026)

Returns include dividend reinvestment.

Year	SPRO	DH
2026	-50.64%	-71.12%
2025	+115.74%	-30.34%
2024	-32.24%	-59.51%
2023	-15.52%	-11.25%
2022	-88.58%	-60.96%
2021	-10.71%	-36.87%
2020	+96.45%	N/A
2019	+53.59%	N/A
2018	-49.34%	N/A
2017	+2.17%	N/A
2015	+125.03%	N/A
2014	-36.85%	N/A
2013	+87.73%	N/A
2012	-15.94%	N/A
2011	-18.88%	N/A
2010	-29.17%	N/A
2009	+37.55%	N/A
2008	-59.66%	N/A
2007	+44.06%	N/A
2006	+26.56%	N/A
2005	-15.34%	N/A
2004	+7.04%	N/A

SPRO vs DH Drawdown Comparison

The maximum drawdown for SPRO was -97.46%, occurring on Apr 8, 2025. This drawdown has not yet recovered.

The maximum drawdown for DH was -98.72%, occurring on Jun 25, 2026. This drawdown has not yet recovered.

The current SPRO drawdown is -94.74%. The current DH drawdown is -98.60%.

Rank	SPRO	DH
#1	-97.46% Dec 28, 2020 - Apr 8, 2025	-98.72% Sep 17, 2021 - Jun 25, 2026
#2	-85.13% Jul 17, 2007 - Nov 2, 2017	N/A
#3	-70.48% Apr 12, 2018 - Dec 8, 2020	N/A
#4	-42.56% May 17, 2005 - Feb 16, 2007	N/A
#5	-32.47% Nov 13, 2017 - Apr 9, 2018	N/A
#6	-18.79% Mar 12, 2007 - Jun 19, 2007	N/A
#7	-9.16% Jun 25, 2007 - Jul 3, 2007	N/A
#8	-8.75% Dec 3, 2004 - Mar 28, 2005	N/A
#9	-5.73% Feb 21, 2007 - Mar 7, 2007	N/A
#10	-5.34% Dec 8, 2020 - Dec 16, 2020	N/A
#11	-4.94% Mar 28, 2005 - May 11, 2005	N/A
#12	-4.48% Dec 17, 2020 - Dec 21, 2020	N/A
#13	-4.01% Jul 9, 2007 - Jul 13, 2007	N/A
#14	-2.82% Nov 22, 2004 - Nov 24, 2004	N/A
#15	-2.50% Nov 24, 2004 - Dec 1, 2004	N/A