SPRB vs SGMO

Comparison between Spruce Biosciences Inc (SPRB, Company) and Sangamo Therapeutics Inc (SGMO, Company).

Both SPRB and SGMO are from the Healthcare sector.

5-Year PerformanceSPRB has outperformed SGMO, delivering a return of -41.4% compared to -56.7%

SPRB vs SGMO - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SPRB(COMPANY)	SGMO(COMPANY)
Market Cap	$68M	$68M
Max Drawdown	99.81%	99.80%
Sharpe Ratio	1.02	-0.16
5Y Beta	1.59	N/A
Industry	Biotechnology	Biotechnology
P/E Ratio	-1.31	-0.53
Forward P/E	N/A	0.40
5Y EPS CAGR	-12.70%	-3.12%
Debt to Equity	18.66%	0.00%
Free Cash Flow Yield	-43.18%	N/A
P/S Ratio	49.19	N/A
P/B Ratio	3.85	N/A

Market Cap

SPRB

$68M

Winner

SGMO

$68M

Max Drawdown

SPRB

99.81%

Winner

SGMO

99.80%

Sharpe Ratio

Winner

SPRB

1.02

SGMO

-0.16

5Y Beta

SPRB

1.59

SGMO

N/A

Industry

SPRB

Biotechnology

SGMO

Biotechnology

P/E Ratio

Winner

SPRB

-1.31

SGMO

-0.53

Forward P/E

SPRB

N/A

SGMO

0.40

5Y EPS CAGR

SPRB

-12.70%

Winner

SGMO

-3.12%

Debt to Equity

SPRB

18.66%

Winner

SGMO

0.00%

Free Cash Flow Yield

SPRB

-43.18%

SGMO

N/A

P/S Ratio

SPRB

49.19

SGMO

N/A

P/B Ratio

SPRB

3.85

SGMO

N/A

SPRB vs SGMO - Historical Returns

Returns include dividend reinvestment.

Period	SPRB	SGMO
1 month	+7.10%	+0.00%
3 months	-7.02%	-47.97%
6 months	-33.95%	-62.13%
1 year	+941.90%	-59.65%
5 years(CAGR)	-41.38%	-56.70%
10 years(CAGR)	N/A	-29.35%
Max(CAGR)	-42.44%	-15.64%

Winner

SPRB

+7.10%

SGMO

+0.00%

Winner

SPRB

-7.02%

SGMO

-47.97%

Winner

SPRB

-33.95%

SGMO

-62.13%

Winner

SPRB

+941.90%

SGMO

-59.65%

5Y(CAGR)

Winner

SPRB

-41.38%

SGMO

-56.70%

10Y(CAGR)

SPRB

N/A

SGMO

-29.35%

Max(CAGR)

SPRB

-42.44%

Winner

SGMO

-15.64%

SPRB vs SGMO - Annual Returns (2000 - 2026)

Returns include dividend reinvestment.

Year	SPRB	SGMO
2026	-39.69%	-60.26%
2025	+176.94%	-62.83%
2024	-85.81%	+83.35%
2023	+154.78%	-82.70%
2022	-76.09%	-59.85%
2021	-80.40%	-52.89%
2020	+43.00%	+90.07%
2019	N/A	-28.95%
2018	N/A	-34.59%
2017	N/A	+429.03%
2016	N/A	-65.92%
2015	N/A	-40.21%
2014	N/A	+10.30%
2013	N/A	+125.85%
2012	N/A	+103.04%
2011	N/A	-59.72%
2010	N/A	+8.14%
2009	N/A	+61.31%
2008	N/A	-72.25%
2007	N/A	+97.29%
2006	N/A	+60.98%
2005	N/A	-30.52%
2004	N/A	+9.29%
2003	N/A	+59.48%
2002	N/A	-66.14%
2001	N/A	-45.86%
2000	N/A	+29.48%

SPRB vs SGMO Drawdown Comparison

The maximum drawdown for SPRB was -99.81%, occurring on Jun 9, 2025. This drawdown has not yet recovered.

The maximum drawdown for SGMO was -99.80%, occurring on May 7, 2026. This drawdown has not yet recovered.

The current SPRB drawdown is -97.75%. The current SGMO drawdown is -99.65%.

Rank	SPRB	SGMO
#1	-99.81% Nov 27, 2020 - Jun 9, 2025	-99.80% Sep 1, 2000 - May 7, 2026
#2	-20.38% Oct 29, 2020 - Nov 13, 2020	-56.01% Apr 6, 2000 - Jun 12, 2000
#3	-13.84% Oct 14, 2020 - Oct 23, 2020	-41.46% Jul 24, 2000 - Aug 29, 2000
#4	-2.56% Nov 20, 2020 - Nov 27, 2020	-20.03% Jun 12, 2000 - Jun 20, 2000
#5	-2.16% Nov 16, 2020 - Nov 18, 2020	-15.18% Jul 11, 2000 - Jul 18, 2000
#6	N/A	-6.25% Jun 23, 2000 - Jun 27, 2000
#7	N/A	-5.08% Jul 5, 2000 - Jul 7, 2000
#8	N/A	-2.71% Jun 30, 2000 - Jul 5, 2000
#9	N/A	-0.54% Jun 28, 2000 - Jun 30, 2000