SLNO vs SPY

Comparison between Soleno Therapeutics Inc (SLNO, Company) and SPDR S&P 500 ETF Trust (SPY, ETF).

5-Year PerformanceSLNO has outperformed SPY, delivering a return of +28.5% compared to +13.9%

SLNO vs SPY - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SLNO(COMPANY)	SPY(ETF)
Market Cap / Net Assets	$2.74B	$735B
Expense Ratio	N/A	0.09%
Max Drawdown	99.86%	56.47%
Sharpe Ratio	-0.21	2.02
5Y Beta	N/A	1.00
Industry	Biotechnology	N/A
P/E Ratio	29.02	28.62
Forward P/E	13.12	22.20
5Y Dividends CAGR	N/A	5.43%
5Y EPS CAGR	N/A	26.35%
Debt to Equity	10.06%	33.33%
Free Cash Flow Yield	3.85%	N/A
P/S Ratio	N/A	3.68
P/B Ratio	N/A	5.52

Market Cap / Net Assets

SLNO

$2.74B

Winner

SPY

$735B

Expense Ratio

SLNO

N/A

SPY

0.09%

Max Drawdown

SLNO

99.86%

Winner

SPY

56.47%

Sharpe Ratio

SLNO

-0.21

Winner

SPY

2.02

5Y Beta

SLNO

N/A

SPY

1.00

Industry

SLNO

Biotechnology

SPY

N/A

P/E Ratio

SLNO

29.02

Winner

SPY

28.62

Forward P/E

Winner

SLNO

13.12

SPY

22.20

5Y Dividends CAGR

SLNO

N/A

SPY

5.43%

5Y EPS CAGR

SLNO

N/A

SPY

26.35%

Debt to Equity

Winner

SLNO

10.06%

SPY

33.33%

Free Cash Flow Yield

SLNO

3.85%

SPY

N/A

P/S Ratio

SLNO

N/A

SPY

3.68

P/B Ratio

SLNO

N/A

SPY

5.52

SLNO vs SPY - Historical Returns

Returns include dividend reinvestment.

Period	SLNO	SPY
1 month	+0.65%	+4.93%
3 months	+34.51%	+9.70%
6 months	+12.79%	+11.04%
1 year	-29.86%	+28.41%
5 years(CAGR)	+28.47%	+13.90%
10 years(CAGR)	-5.91%	+15.45%
Max(CAGR)	-13.75%	+8.55%

SLNO

+0.65%

Winner

SPY

+4.93%

Winner

SLNO

+34.51%

SPY

+9.70%

Winner

SLNO

+12.79%

SPY

+11.04%

SLNO

-29.86%

Winner

SPY

+28.41%

5Y(CAGR)

Winner

SLNO

+28.47%

SPY

+13.90%

10Y(CAGR)

SLNO

-5.91%

Winner

SPY

+15.45%

Max(CAGR)

SLNO

-13.75%

Winner

SPY

+8.55%

SLNO vs SPY - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	SLNO	SPY
2026	+12.38%	+10.15%
2025	+1.29%	+18.00%
2024	+18.45%	+25.59%
2023	+1737.90%	+26.72%
2022	-70.09%	-18.64%
2021	-79.60%	+30.52%
2020	-31.07%	+17.28%
2019	+53.93%	+31.09%
2018	-6.56%	-5.24%
2017	-55.56%	+20.78%
2016	-56.22%	+13.59%
2015	+23.33%	+1.31%
2014	-61.56%	+14.56%
2013	N/A	+29.00%
2012	N/A	+14.17%
2011	N/A	+0.85%
2010	N/A	+13.14%
2009	N/A	+22.67%
2008	N/A	-36.25%
2007	N/A	+5.32%
2006	N/A	+13.85%
2005	N/A	+5.32%
2004	N/A	+10.75%
2003	N/A	+24.18%
2002	N/A	-22.42%
2001	N/A	-10.13%
2000	N/A	-8.84%
1999	N/A	+8.61%

SLNO vs SPY Drawdown Comparison

The maximum drawdown for SLNO was -99.86%, occurring on Dec 15, 2022. This drawdown has not yet recovered.

The maximum drawdown for SPY was -55.20%, occurring on Mar 9, 2009. Recovery took 1224 trading sessions.

The current SLNO drawdown is -91.92%. The current SPY drawdown is -0.02%.

Rank	SLNO	SPY
#1	-99.86% Mar 4, 2015 - Dec 15, 2022	-55.20% Oct 9, 2007 - Aug 16, 2012
#2	-70.79% Nov 17, 2014 - Feb 19, 2015	-47.50% Mar 24, 2000 - Oct 26, 2006
#3	-9.74% Feb 26, 2015 - Mar 3, 2015	-33.70% Feb 19, 2020 - Aug 10, 2020
#4	-8.35% Feb 24, 2015 - Feb 26, 2015	-24.50% Jan 3, 2022 - Dec 13, 2023
#5	-7.31% Feb 19, 2015 - Feb 23, 2015	-19.34% Sep 20, 2018 - Apr 12, 2019
#6	N/A	-18.76% Feb 19, 2025 - Jun 26, 2025
#7	N/A	-13.02% Jul 20, 2015 - Apr 18, 2016
#8	N/A	-10.10% Jan 26, 2018 - Aug 6, 2018
#9	N/A	-9.44% Sep 2, 2020 - Nov 11, 2020
#10	N/A	-9.30% Jan 19, 2000 - Mar 17, 2000
#11	N/A	-9.05% Jul 19, 2007 - Oct 5, 2007
#12	N/A	-8.88% Jan 27, 2026 - Apr 14, 2026
#13	N/A	-8.41% Jul 16, 2024 - Sep 19, 2024
#14	N/A	-7.35% Sep 14, 2012 - Jan 2, 2013
#15	N/A	-7.27% Sep 18, 2014 - Oct 31, 2014

Correlation

Correlation between SLNO and SPY is -0.30 which considered as a weak negative correlation - the stocks show a slight tendency to move in opposite directions.

-0.30

-101