SION vs SPSC
Comparison between Sionna Therapeutics Inc (SION, Company) and SPS Commerce Inc (SPSC, Company).
SION is from the Healthcare sector, while SPSC is from the Technology sector.
SION vs SPSC - Performance Comparison
Key Characteristics
Financial metrics and valuation ratios
Market Cap
SION
$1.96B
Winner
SPSC
$1.96B
Max Drawdown
Winner
SION
69.36%
SPSC
76.83%
Sharpe Ratio
Winner
SION
1.34
SPSC
-1.80
5Y Beta
Winner
SION
0.95
SPSC
1.02
Industry
SION
Biotechnology
SPSC
Software - Application
P/E Ratio
Winner
SION
-22.66
SPSC
21.90
Forward P/E
SION
N/A
SPSC
68.03
PEG Ratio
SION
N/A
SPSC
1.82
5Y EPS CAGR
SION
N/A
SPSC
13.14%
Debt to Equity
SION
0.00%
SPSC
0.00%
Free Cash Flow Yield
SION
-3.69%
Winner
SPSC
8.52%
P/S Ratio
SION
N/A
SPSC
2.55
P/B Ratio
SION
6.71
Winner
SPSC
2.04
SION vs SPSC - Historical Returns
Returns include dividend reinvestment.
1M
SION
-13.67%
Winner
SPSC
-5.02%
3M
Winner
SION
+2.34%
SPSC
-13.40%
6M
Winner
SION
-12.21%
SPSC
-33.73%
1Y
Winner
SION
+120.65%
SPSC
-61.01%
5Y(CAGR)
SION
N/A
SPSC
-10.11%
10Y(CAGR)
SION
N/A
SPSC
+6.76%
Max(CAGR)
Winner
SION
+30.00%
SPSC
+13.91%
SION vs SPSC - Annual Returns (2010 - 2026)
Returns include dividend reinvestment.
| Year | SION | SPSC |
|---|---|---|
| 2026 | -9.79% | -36.90% |
| 2025 | +64.56% | -51.24% |
| 2024 | N/A | -0.17% |
| 2023 | N/A | +51.43% |
| 2022 | N/A | -7.22% |
| 2021 | N/A | +26.88% |
| 2020 | N/A | +93.57% |
| 2019 | N/A | +35.47% |
| 2018 | N/A | +69.05% |
| 2017 | N/A | -30.07% |
| 2016 | N/A | +3.08% |
| 2015 | N/A | +26.25% |
| 2014 | N/A | -12.07% |
| 2013 | N/A | +66.07% |
| 2012 | N/A | +49.08% |
| 2011 | N/A | +66.67% |
| 2010 | N/A | +16.18% |
SION vs SPSC Drawdown Comparison
The maximum drawdown for SION was -69.36%, occurring on Apr 10, 2025. Recovery took 137 trading sessions.
The maximum drawdown for SPSC was -76.83%, occurring on May 13, 2026. This drawdown has not yet recovered.
The current SION drawdown is -23.03%. The current SPSC drawdown is -74.25%.
| Rank | SION | SPSC |
|---|---|---|
| #1 | -69.36% Feb 7, 2025 - Aug 26, 2025 | -76.83% Jul 31, 2024 - May 13, 2026 |
| #2 | -23.74% Feb 3, 2026 - Apr 15, 2026 | -49.97% Oct 21, 2013 - Jul 27, 2018 |
| #3 | -23.03% May 11, 2026 - Jun 5, 2026 | -47.62% Feb 18, 2020 - May 20, 2020 |
| #4 | -19.06% Oct 21, 2025 - Nov 21, 2025 | -43.58% Oct 28, 2021 - Jun 12, 2023 |
| #5 | -18.12% Nov 24, 2025 - Feb 3, 2026 | -38.17% Apr 23, 2010 - Nov 8, 2010 |
| #6 | -17.26% Apr 16, 2026 - May 11, 2026 | -23.36% Feb 9, 2024 - Jul 31, 2024 |
| #7 | -15.94% Aug 28, 2025 - Sep 22, 2025 | -23.32% Sep 14, 2018 - Feb 13, 2019 |
| #8 | -5.53% Oct 3, 2025 - Oct 15, 2025 | -20.84% Jul 18, 2023 - Dec 26, 2023 |
| #9 | -3.56% Sep 29, 2025 - Oct 3, 2025 | -20.30% Feb 8, 2011 - May 2, 2011 |
| #10 | -2.41% Oct 16, 2025 - Oct 21, 2025 | -20.28% Jan 7, 2021 - Aug 13, 2021 |
| #11 | -0.36% Aug 26, 2025 - Aug 28, 2025 | -19.47% Jul 26, 2019 - Nov 25, 2019 |
| #12 | N/A | -18.56% Oct 4, 2012 - Mar 26, 2013 |
| #13 | N/A | -18.23% Jul 21, 2011 - Oct 12, 2011 |
| #14 | N/A | -16.77% Nov 10, 2010 - Dec 10, 2010 |
| #15 | N/A | -16.70% Feb 8, 2012 - Apr 27, 2012 |
Correlation
Correlation between SION and SPSC is -0.88 which considered as a strong negative correlation - the stocks tend to move in opposite directions.
-0.88
-101
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