SGMO vs SPRB

Comparison between Sangamo Therapeutics Inc (SGMO, Company) and Spruce Biosciences Inc (SPRB, Company).

Both SGMO and SPRB are from the Healthcare sector.

5-Year PerformanceSPRB has outperformed SGMO, delivering a return of -43.0% compared to -56.6%

SGMO vs SPRB - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SGMO(COMPANY)	SPRB(COMPANY)
Market Cap	$68M	$68M
Max Drawdown	99.80%	99.81%
Sharpe Ratio	-0.16	1.01
5Y Beta	N/A	1.59
Industry	Biotechnology	Biotechnology
P/E Ratio	-0.53	-1.31
Forward P/E	0.40	N/A
5Y EPS CAGR	-3.12%	-12.70%
Debt to Equity	0.00%	18.66%
Free Cash Flow Yield	N/A	-43.18%
P/S Ratio	N/A	49.19
P/B Ratio	N/A	3.85

Market Cap

Winner

SGMO

$68M

SPRB

$68M

Max Drawdown

Winner

SGMO

99.80%

SPRB

99.81%

Sharpe Ratio

SGMO

-0.16

Winner

SPRB

1.01

5Y Beta

SGMO

N/A

SPRB

1.59

Industry

SGMO

Biotechnology

SPRB

Biotechnology

P/E Ratio

SGMO

-0.53

Winner

SPRB

-1.31

Forward P/E

SGMO

0.40

SPRB

N/A

5Y EPS CAGR

Winner

SGMO

-3.12%

SPRB

-12.70%

Debt to Equity

Winner

SGMO

0.00%

SPRB

18.66%

Free Cash Flow Yield

SGMO

N/A

SPRB

-43.18%

P/S Ratio

SGMO

N/A

SPRB

49.19

P/B Ratio

SGMO

N/A

SPRB

3.85

SGMO vs SPRB - Historical Returns

Returns include dividend reinvestment.

Period	SGMO	SPRB
1 month	+36.76%	+1.85%
3 months	-51.53%	-10.88%
6 months	-59.42%	-31.80%
1 year	-64.47%	+871.64%
5 years(CAGR)	-56.61%	-42.95%
10 years(CAGR)	-29.33%	N/A
Max(CAGR)	-15.65%	-42.95%

Winner

SGMO

+36.76%

SPRB

+1.85%

SGMO

-51.53%

Winner

SPRB

-10.88%

SGMO

-59.42%

Winner

SPRB

-31.80%

SGMO

-64.47%

Winner

SPRB

+871.64%

5Y(CAGR)

SGMO

-56.61%

Winner

SPRB

-42.95%

10Y(CAGR)

SGMO

-29.33%

SPRB

N/A

Max(CAGR)

Winner

SGMO

-15.65%

SPRB

-42.95%

SGMO vs SPRB - Annual Returns (2000 - 2026)

Returns include dividend reinvestment.

Year	SGMO	SPRB
2026	-60.21%	-42.27%
2025	-62.83%	+176.94%
2024	+83.35%	-85.81%
2023	-82.70%	+154.78%
2022	-59.85%	-76.09%
2021	-52.89%	-80.40%
2020	+90.07%	+43.00%
2019	-28.95%	N/A
2018	-34.59%	N/A
2017	+429.03%	N/A
2016	-65.92%	N/A
2015	-40.21%	N/A
2014	+10.30%	N/A
2013	+125.85%	N/A
2012	+103.04%	N/A
2011	-59.72%	N/A
2010	+8.14%	N/A
2009	+61.31%	N/A
2008	-72.25%	N/A
2007	+97.29%	N/A
2006	+60.98%	N/A
2005	-30.52%	N/A
2004	+9.29%	N/A
2003	+59.48%	N/A
2002	-66.14%	N/A
2001	-45.86%	N/A
2000	+29.48%	N/A

SGMO vs SPRB Drawdown Comparison

The maximum drawdown for SGMO was -99.80%, occurring on May 7, 2026. This drawdown has not yet recovered.

The maximum drawdown for SPRB was -99.81%, occurring on Jun 9, 2025. This drawdown has not yet recovered.

The current SGMO drawdown is -99.65%. The current SPRB drawdown is -97.85%.

Rank	SGMO	SPRB
#1	-99.80% Sep 1, 2000 - May 7, 2026	-99.81% Nov 27, 2020 - Jun 9, 2025
#2	-56.01% Apr 6, 2000 - Jun 12, 2000	-20.38% Oct 29, 2020 - Nov 13, 2020
#3	-41.46% Jul 24, 2000 - Aug 29, 2000	-13.84% Oct 14, 2020 - Oct 23, 2020
#4	-20.03% Jun 12, 2000 - Jun 20, 2000	-2.56% Nov 20, 2020 - Nov 27, 2020
#5	-15.18% Jul 11, 2000 - Jul 18, 2000	-2.16% Nov 16, 2020 - Nov 18, 2020
#6	-6.25% Jun 23, 2000 - Jun 27, 2000	N/A
#7	-5.08% Jul 5, 2000 - Jul 7, 2000	N/A
#8	-2.71% Jun 30, 2000 - Jul 5, 2000	N/A
#9	-0.54% Jun 28, 2000 - Jun 30, 2000	N/A