SEPN vs PVLA

Comparison between Septerna Inc (SEPN, Company) and Palvella Therapeutics Inc (PVLA, Company).

Both SEPN and PVLA are from the Healthcare sector.

SEPN vs PVLA - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SEPN(COMPANY)	PVLA(COMPANY)
Market Cap	$1.62B	$1.62B
Max Drawdown	81.47%	31.48%
Sharpe Ratio	2.26	2.41
5Y Beta	1.32	1.04
Industry	Biotechnology	Biotechnology
P/E Ratio	-44.87	-28.22
Forward P/E	107.53	N/A
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	6.58%	-1.80%

Market Cap

Winner

SEPN

$1.62B

PVLA

$1.62B

Max Drawdown

SEPN

81.47%

Winner

PVLA

31.48%

Sharpe Ratio

SEPN

2.26

Winner

PVLA

2.41

5Y Beta

SEPN

1.32

Winner

PVLA

1.04

Industry

SEPN

Biotechnology

PVLA

Biotechnology

P/E Ratio

Winner

SEPN

-44.87

PVLA

-28.22

Forward P/E

SEPN

107.53

PVLA

N/A

Debt to Equity

SEPN

0.00%

PVLA

0.00%

Free Cash Flow Yield

Winner

SEPN

6.58%

PVLA

-1.80%

SEPN vs PVLA - Historical Returns

Returns include dividend reinvestment.

Period	SEPN	PVLA
1 month	+37.53%	+7.66%
3 months	+50.02%	-0.99%
6 months	+31.34%	+17.52%
1 year	+244.80%	+451.44%
Max(CAGR)	+37.57%	+325.47%

Winner

SEPN

+37.53%

PVLA

+7.66%

Winner

SEPN

+50.02%

PVLA

-0.99%

Winner

SEPN

+31.34%

PVLA

+17.52%

SEPN

+244.80%

Winner

PVLA

+451.44%

Max(CAGR)

SEPN

+37.57%

Winner

PVLA

+325.47%

SEPN vs PVLA - Annual Returns (2024 - 2026)

Returns include dividend reinvestment.

Year	SEPN	PVLA
2026	+29.27%	+12.78%
2025	+30.59%	+772.25%
2024	+7.01%	-6.47%

SEPN vs PVLA Drawdown Comparison

The maximum drawdown for SEPN was -81.47%, occurring on Apr 1, 2025. Recovery took 230 trading sessions.

The maximum drawdown for PVLA was -31.48%, occurring on Apr 10, 2025. Recovery took 87 trading sessions.

The current PVLA drawdown is -23.76%.

Rank	SEPN	PVLA
#1	-81.47% Dec 23, 2024 - Nov 24, 2025	-31.48% Mar 12, 2025 - Jul 17, 2025
#2	-25.18% Feb 24, 2026 - May 28, 2026	-31.11% Feb 26, 2026 - Jun 10, 2026
#3	-21.10% Dec 19, 2025 - Feb 17, 2026	-29.93% Dec 22, 2025 - Feb 24, 2026
#4	-16.77% Dec 4, 2024 - Dec 23, 2024	-15.35% Jan 6, 2025 - Feb 5, 2025
#5	-16.19% Nov 7, 2024 - Dec 4, 2024	-13.44% Nov 28, 2025 - Dec 22, 2025
#6	-13.97% Nov 26, 2025 - Dec 19, 2025	-10.43% Feb 18, 2025 - Mar 5, 2025
#7	-10.63% Feb 17, 2026 - Feb 24, 2026	-9.32% Oct 20, 2025 - Oct 30, 2025
#8	-6.45% Oct 25, 2024 - Oct 31, 2024	-9.31% Dec 17, 2024 - Jan 3, 2025
#9	-4.76% Oct 31, 2024 - Nov 4, 2024	-9.12% Aug 27, 2025 - Sep 9, 2025
#10	-3.57% May 28, 2026 - Jun 4, 2026	-8.74% Sep 10, 2025 - Sep 29, 2025
#11	-3.45% Nov 4, 2024 - Nov 6, 2024	-8.33% Jul 28, 2025 - Aug 8, 2025
#12	-3.06% Jun 4, 2026 - Jun 11, 2026	-6.61% Oct 8, 2025 - Oct 13, 2025
#13	-2.39% Jun 15, 2026 - Jun 18, 2026	-6.16% Aug 22, 2025 - Aug 26, 2025
#14	-1.89% Nov 24, 2025 - Nov 26, 2025	-5.99% Oct 31, 2025 - Nov 10, 2025
#15	N/A	-5.54% Nov 19, 2025 - Nov 24, 2025