SEPN vs MPLT

Comparison between Septerna Inc (SEPN, Company) and MapLight Therapeutics Inc (MPLT, Company).

Both SEPN and MPLT are from the Healthcare sector.

SEPN vs MPLT - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SEPN(COMPANY)	MPLT(COMPANY)
Market Cap	$1.34B	$1.34B
Max Drawdown	81.47%	30.27%
Sharpe Ratio	2.08	1.18
5Y Beta	1.30	1.46
Industry	Biotechnology	Biotechnology
P/E Ratio	-36.95	-8.07
Forward P/E	107.53	N/A
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	7.99%	-16.93%
P/S Ratio	18.84	N/A
P/B Ratio	3.59	3.38

Market Cap

Winner

SEPN

$1.34B

MPLT

$1.34B

Max Drawdown

SEPN

81.47%

Winner

MPLT

30.27%

Sharpe Ratio

Winner

SEPN

2.08

MPLT

1.18

5Y Beta

Winner

SEPN

1.30

MPLT

1.46

Industry

SEPN

Biotechnology

MPLT

Biotechnology

P/E Ratio

Winner

SEPN

-36.95

MPLT

-8.07

Forward P/E

SEPN

107.53

MPLT

N/A

Debt to Equity

SEPN

0.00%

MPLT

0.00%

Free Cash Flow Yield

Winner

SEPN

7.99%

MPLT

-16.93%

P/S Ratio

SEPN

18.84

MPLT

N/A

P/B Ratio

SEPN

3.59

Winner

MPLT

3.38

SEPN vs MPLT - Historical Returns

Returns include dividend reinvestment.

Period	SEPN	MPLT
1 month	+29.09%	+0.32%
3 months	+13.40%	+55.96%
6 months	+16.41%	+51.49%
1 year	+196.10%	N/A
Max(CAGR)	+26.26%	+101.35%

Winner

SEPN

+29.09%

MPLT

+0.32%

SEPN

+13.40%

Winner

MPLT

+55.96%

SEPN

+16.41%

Winner

MPLT

+51.49%

SEPN

+196.10%

MPLT

N/A

Max(CAGR)

SEPN

+26.26%

Winner

MPLT

+101.35%

SEPN vs MPLT - Annual Returns (2024 - 2026)

Returns include dividend reinvestment.

Year	SEPN	MPLT
2026	+11.33%	+67.02%
2025	+30.59%	-4.23%
2024	+7.01%	N/A

SEPN vs MPLT Drawdown Comparison

The maximum drawdown for SEPN was -81.47%, occurring on Apr 1, 2025. Recovery took 230 trading sessions.

The maximum drawdown for MPLT was -30.27%, occurring on Nov 25, 2025. Recovery took 25 trading sessions.

The current SEPN drawdown is -0.70%. The current MPLT drawdown is -12.82%.

Rank	SEPN	MPLT
#1	-81.47% Dec 23, 2024 - Nov 24, 2025	-30.27% Oct 30, 2025 - Dec 5, 2025
#2	-25.18% Feb 24, 2026 - May 28, 2026	-25.52% Dec 15, 2025 - Apr 2, 2026
#3	-21.10% Dec 19, 2025 - Feb 17, 2026	-17.52% Apr 22, 2026 - May 18, 2026
#4	-16.77% Dec 4, 2024 - Dec 23, 2024	-10.54% Apr 9, 2026 - Apr 17, 2026
#5	-16.19% Nov 7, 2024 - Dec 4, 2024	-9.76% Oct 27, 2025 - Oct 30, 2025
#6	-13.97% Nov 26, 2025 - Dec 19, 2025	-8.09% Apr 17, 2026 - Apr 22, 2026
#7	-10.63% Feb 17, 2026 - Feb 24, 2026	-1.54% Dec 10, 2025 - Dec 12, 2025
#8	-6.45% Oct 25, 2024 - Oct 31, 2024	-0.22% Dec 5, 2025 - Dec 9, 2025
#9	-4.76% Oct 31, 2024 - Nov 4, 2024	N/A
#10	-3.57% May 28, 2026 - Jun 4, 2026	N/A
#11	-3.45% Nov 4, 2024 - Nov 6, 2024	N/A
#12	-1.89% Nov 24, 2025 - Nov 26, 2025	N/A
#13	-0.70% Jun 4, 2026 - Jun 5, 2026	N/A