SEPN vs ALVO

Comparison between Septerna Inc (SEPN, Company) and Alvotech (ALVO, Company).

Both SEPN and ALVO are from the Healthcare sector.

SEPN vs ALVO - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SEPN(COMPANY)	ALVO(COMPANY)
Market Cap	$1.37B	$1.37B
Max Drawdown	81.47%	82.63%
Sharpe Ratio	2.15	-0.94
5Y Beta	1.33	0.82
Industry	Biotechnology	Drug Manufacturers - Specialty & Generic
P/E Ratio	-37.80	-13.76
Forward P/E	107.53	7.91
5Y EPS CAGR	N/A	-18.97%
Debt to Equity	0.00%	-516.20%
Free Cash Flow Yield	7.81%	-12.54%
P/S Ratio	19.01	2.30
P/B Ratio	3.62	N/A

Market Cap

Winner

SEPN

$1.37B

ALVO

$1.37B

Max Drawdown

Winner

SEPN

81.47%

ALVO

82.63%

Sharpe Ratio

Winner

SEPN

2.15

ALVO

-0.94

5Y Beta

SEPN

1.33

Winner

ALVO

0.82

Industry

SEPN

Biotechnology

ALVO

Drug Manufacturers - Specialty & Generic

P/E Ratio

Winner

SEPN

-37.80

ALVO

-13.76

Forward P/E

SEPN

107.53

Winner

ALVO

7.91

5Y EPS CAGR

SEPN

N/A

ALVO

-18.97%

Debt to Equity

SEPN

0.00%

Winner

ALVO

-516.20%

Free Cash Flow Yield

Winner

SEPN

7.81%

ALVO

-12.54%

P/S Ratio

SEPN

19.01

Winner

ALVO

2.30

P/B Ratio

SEPN

3.62

ALVO

N/A

SEPN vs ALVO - Historical Returns

Returns include dividend reinvestment.

Period	SEPN	ALVO
1 month	+44.73%	+17.46%
3 months	+35.94%	+17.80%
6 months	+41.31%	-25.13%
1 year	+245.34%	-57.62%
Max(CAGR)	+37.50%	-21.92%

Winner

SEPN

+44.73%

ALVO

+17.46%

Winner

SEPN

+35.94%

ALVO

+17.80%

Winner

SEPN

+41.31%

ALVO

-25.13%

Winner

SEPN

+245.34%

ALVO

-57.62%

Max(CAGR)

Winner

SEPN

+37.50%

ALVO

-21.92%

SEPN vs ALVO - Annual Returns (2022 - 2026)

Returns include dividend reinvestment.

Year	SEPN	ALVO
2026	+28.48%	-16.60%
2025	+30.59%	-61.02%
2024	+7.01%	+16.46%
2023	N/A	+14.69%
2022	N/A	-10.63%

SEPN vs ALVO Drawdown Comparison

The maximum drawdown for SEPN was -81.47%, occurring on Apr 1, 2025. Recovery took 230 trading sessions.

The maximum drawdown for ALVO was -82.63%, occurring on Jun 2, 2026. This drawdown has not yet recovered.

The current ALVO drawdown is -75.85%.

Rank	SEPN	ALVO
#1	-81.47% Dec 23, 2024 - Nov 24, 2025	-82.63% Feb 26, 2024 - Jun 2, 2026
#2	-25.18% Feb 24, 2026 - May 28, 2026	-50.82% Mar 2, 2023 - Jan 19, 2024
#3	-21.10% Dec 19, 2025 - Feb 17, 2026	-50.58% Jun 16, 2022 - Jan 9, 2023
#4	-16.77% Dec 4, 2024 - Dec 23, 2024	-8.17% Jan 13, 2023 - Feb 6, 2023
#5	-16.19% Nov 7, 2024 - Dec 4, 2024	-2.95% Feb 1, 2024 - Feb 20, 2024
#6	-13.97% Nov 26, 2025 - Dec 19, 2025	-2.50% Feb 20, 2024 - Feb 23, 2024
#7	-10.63% Feb 17, 2026 - Feb 24, 2026	-1.71% Feb 16, 2023 - Feb 24, 2023
#8	-6.45% Oct 25, 2024 - Oct 31, 2024	-1.42% Feb 10, 2023 - Feb 16, 2023
#9	-4.76% Oct 31, 2024 - Nov 4, 2024	-0.83% Jan 10, 2023 - Jan 13, 2023
#10	-3.57% May 28, 2026 - Jun 4, 2026	-0.79% Jan 29, 2024 - Jan 31, 2024
#11	-3.45% Nov 4, 2024 - Nov 6, 2024	-0.43% Feb 27, 2023 - Mar 1, 2023
#12	-3.06% Jun 4, 2026 - Jun 11, 2026	-0.07% Jan 23, 2024 - Jan 26, 2024
#13	-1.89% Nov 24, 2025 - Nov 26, 2025	N/A

Correlation

Correlation between SEPN and ALVO is -0.54 which considered as a moderate negative correlation - the stocks show some tendency to move in opposite directions.

-0.54

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