PRTA vs GUG

Comparison between Prothena Corporation plc (PRTA, Company) and Guggenheim Active Allocation Fund (GUG, Company).

PRTA is from the Healthcare sector, while GUG is from the Financial Services sector.

5-Year PerformanceGUG has outperformed PRTA, delivering a return of +3.8% compared to -21.0%

PRTA vs GUG - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	PRTA(COMPANY)	GUG(COMPANY)
Market Cap	$532M	$532M
Max Drawdown	94.19%	37.03%
Sharpe Ratio	1.36	0.80
5Y Beta	0.93	0.35
Industry	Biotechnology	Asset Management
P/E Ratio	-3.58	11.52
Forward P/E	10.63	N/A
PEG Ratio	-0.10	N/A
5Y EPS CAGR	-1.54%	N/A
Debt to Equity	0.00%	31.43%
Free Cash Flow Yield	-15.28%	5.89%
P/S Ratio	9.06	12.57
P/B Ratio	1.69	0.97

Market Cap

Winner

PRTA

$532M

GUG

$532M

Max Drawdown

PRTA

94.19%

Winner

GUG

37.03%

Sharpe Ratio

Winner

PRTA

1.36

GUG

0.80

5Y Beta

PRTA

0.93

Winner

GUG

0.35

Industry

PRTA

Biotechnology

GUG

Asset Management

P/E Ratio

Winner

PRTA

-3.58

GUG

11.52

Forward P/E

PRTA

10.63

GUG

N/A

PEG Ratio

PRTA

-0.10

GUG

N/A

5Y EPS CAGR

PRTA

-1.54%

GUG

N/A

Debt to Equity

Winner

PRTA

0.00%

GUG

31.43%

Free Cash Flow Yield

PRTA

-15.28%

Winner

GUG

5.89%

P/S Ratio

Winner

PRTA

9.06

GUG

12.57

P/B Ratio

PRTA

1.69

Winner

GUG

0.97

PRTA vs GUG - Historical Returns

Returns include dividend reinvestment.

Period	PRTA	GUG
1 month	-21.45%	-0.39%
3 months	-7.08%	+0.63%
6 months	-20.60%	+4.76%
1 year	+73.72%	+12.91%
5 years(CAGR)	-21.04%	+3.76%
10 years(CAGR)	-16.03%	N/A
Max(CAGR)	+1.49%	+3.76%

PRTA

-21.45%

Winner

GUG

-0.39%

PRTA

-7.08%

Winner

GUG

+0.63%

PRTA

-20.60%

Winner

GUG

+4.76%

Winner

PRTA

+73.72%

GUG

+12.91%

5Y(CAGR)

PRTA

-21.04%

Winner

GUG

+3.76%

10Y(CAGR)

PRTA

-16.03%

GUG

N/A

Max(CAGR)

PRTA

+1.49%

Winner

GUG

+3.76%

PRTA vs GUG - Annual Returns (2012 - 2026)

Returns include dividend reinvestment.

Year	PRTA	GUG
2026	-4.46%	+6.06%
2025	-30.14%	+12.35%
2024	-64.06%	+11.59%
2023	-32.07%	+19.29%
2022	+22.41%	-26.97%
2021	+301.63%	-0.20%
2020	-23.16%	N/A
2019	+50.76%	N/A
2018	-72.75%	N/A
2017	-24.70%	N/A
2016	-20.94%	N/A
2015	+234.69%	N/A
2014	-26.12%	N/A
2013	+278.86%	N/A
2012	+1.81%	N/A

PRTA vs GUG Drawdown Comparison

The maximum drawdown for PRTA was -94.19%, occurring on May 27, 2025. This drawdown has not yet recovered.

The maximum drawdown for GUG was -32.74%, occurring on Sep 29, 2022. Recovery took 675 trading sessions.

The current PRTA drawdown is -88.86%. The current GUG drawdown is -3.99%.

Rank	PRTA	GUG
#1	-94.19% Sep 23, 2021 - May 27, 2025	-32.74% Dec 21, 2021 - Aug 29, 2024
#2	-90.85% Nov 27, 2015 - Sep 10, 2021	-12.09% Sep 16, 2024 - Jun 24, 2025
#3	-64.27% Mar 20, 2014 - Jun 17, 2015	-7.80% Feb 13, 2026 - May 21, 2026
#4	-36.96% Jul 28, 2015 - Nov 18, 2015	-6.10% Oct 7, 2025 - Jan 13, 2026
#5	-20.33% Dec 31, 2012 - Apr 9, 2013	-3.99% May 28, 2026 - Jun 5, 2026
#6	-18.45% Jun 20, 2013 - Jul 12, 2013	-3.53% Sep 11, 2025 - Oct 7, 2025
#7	-17.61% Jan 30, 2014 - Feb 25, 2014	-2.62% Jun 25, 2025 - Aug 12, 2025
#8	-15.12% Dec 16, 2013 - Jan 29, 2014	-1.71% Jan 14, 2026 - Feb 5, 2026
#9	-14.72% Oct 2, 2013 - Oct 25, 2013	-1.05% Sep 4, 2025 - Sep 9, 2025
#10	-11.68% May 28, 2013 - Jun 7, 2013	-0.90% Aug 14, 2025 - Aug 22, 2025
#11	-10.76% Aug 2, 2013 - Aug 22, 2013	-0.90% Aug 30, 2024 - Sep 5, 2024
#12	-10.14% Jun 22, 2015 - Jul 14, 2015	-0.86% Feb 9, 2026 - Feb 13, 2026
#13	-7.65% Mar 12, 2014 - Mar 19, 2014	-0.74% Sep 9, 2025 - Sep 11, 2025
#14	-6.94% Aug 29, 2013 - Oct 2, 2013	-0.64% Aug 25, 2025 - Aug 28, 2025
#15	-6.73% Jul 22, 2015 - Jul 28, 2015	-0.20% Dec 8, 2021 - Dec 17, 2021