PEN vs MDGL

Comparison between Penumbra Inc (PEN, Company) and Madrigal Pharmaceuticals Inc (MDGL, Company).

Both PEN and MDGL are from the Healthcare sector.

5-Year PerformanceMDGL has outperformed PEN, delivering a return of +43.7% compared to +3.7%

PEN vs MDGL - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	PEN(COMPANY)	MDGL(COMPANY)
Market Cap	$12B	$12B
Max Drawdown	62.64%	98.40%
Sharpe Ratio	0.99	1.45
5Y Beta	0.53	0.77
Industry	Medical Devices	Biotechnology
P/E Ratio	75.61	-39.55
Forward P/E	62.50	666.67
PEG Ratio	4.07	0.00
5Y EPS CAGR	46.16%	23.26%
Debt to Equity	0.00%	62.62%
Free Cash Flow Yield	1.71%	-2.21%
P/S Ratio	8.56	10.95
P/B Ratio	8.47	23.20

Market Cap

Winner

PEN

$12B

MDGL

$12B

Max Drawdown

Winner

PEN

62.64%

MDGL

98.40%

Sharpe Ratio

PEN

0.99

Winner

MDGL

1.45

5Y Beta

Winner

PEN

0.53

MDGL

0.77

Industry

PEN

Medical Devices

MDGL

Biotechnology

P/E Ratio

PEN

75.61

Winner

MDGL

-39.55

Forward P/E

Winner

PEN

62.50

MDGL

666.67

PEG Ratio

PEN

4.07

Winner

MDGL

0.00

5Y EPS CAGR

Winner

PEN

46.16%

MDGL

23.26%

Debt to Equity

Winner

PEN

0.00%

MDGL

62.62%

Free Cash Flow Yield

Winner

PEN

1.71%

MDGL

-2.21%

P/S Ratio

Winner

PEN

8.56

MDGL

10.95

P/B Ratio

Winner

PEN

8.47

MDGL

23.20

PEN vs MDGL - Historical Returns

Returns include dividend reinvestment.

Period	PEN	MDGL
1 month	+0.75%	+6.82%
3 months	-3.38%	+6.27%
6 months	-11.28%	+13.33%
1 year	+38.47%	+82.01%
5 years(CAGR)	+3.65%	+43.73%
10 years(CAGR)	+17.97%	+48.94%
Max(CAGR)	+20.73%	+2.80%

PEN

+0.75%

Winner

MDGL

+6.82%

PEN

-3.38%

Winner

MDGL

+6.27%

PEN

-11.28%

Winner

MDGL

+13.33%

PEN

+38.47%

Winner

MDGL

+82.01%

5Y(CAGR)

PEN

+3.65%

Winner

MDGL

+43.73%

10Y(CAGR)

PEN

+17.97%

Winner

MDGL

+48.94%

Max(CAGR)

Winner

PEN

+20.73%

MDGL

+2.80%

PEN vs MDGL - Annual Returns (2007 - 2026)

Returns include dividend reinvestment.

Year	PEN	MDGL
2026	+3.01%	-8.31%
2025	+29.55%	+85.59%
2024	-2.98%	+36.02%
2023	+13.72%	-18.93%
2022	-21.66%	+222.07%
2021	+63.62%	-22.80%
2020	+6.84%	+22.60%
2019	+33.48%	-18.06%
2018	+35.25%	+15.71%
2017	+46.92%	+475.13%
2016	+14.52%	+28.97%
2015	+30.29%	-87.74%
2014	N/A	-49.62%
2013	N/A	-45.64%
2012	N/A	+84.46%
2011	N/A	-24.56%
2010	N/A	+10.87%
2009	N/A	-17.99%
2008	N/A	-3.62%
2007	N/A	-26.29%

PEN vs MDGL Drawdown Comparison

The maximum drawdown for PEN was -62.64%, occurring on Jun 16, 2022. Recovery took 511 trading sessions.

The maximum drawdown for MDGL was -98.40%, occurring on Feb 11, 2016. Recovery took 3162 trading sessions.

The current PEN drawdown is -11.32%. The current MDGL drawdown is -9.67%.

Rank	PEN	MDGL
#1	-62.64% Apr 28, 2021 - May 9, 2023	-98.40% Jan 28, 2013 - Aug 22, 2025
#2	-52.44% Jun 30, 2023 - Jan 15, 2026	-87.64% Oct 5, 2007 - Jan 22, 2013
#3	-35.86% Nov 12, 2020 - Feb 9, 2021	-51.43% Jun 4, 2007 - Oct 4, 2007
#4	-35.83% Feb 19, 2020 - Jul 8, 2020	-29.36% Dec 22, 2025 - Mar 3, 2026
#5	-31.65% Jun 6, 2018 - Jun 14, 2019	-18.88% Feb 9, 2007 - Jun 4, 2007
#6	-28.12% Jul 24, 2019 - Feb 11, 2020	-10.10% Sep 30, 2025 - Nov 5, 2025
#7	-26.97% Nov 9, 2017 - Mar 6, 2018	-9.42% Nov 26, 2025 - Dec 22, 2025
#8	-26.12% Sep 22, 2016 - Feb 21, 2017	-8.01% Sep 8, 2025 - Sep 30, 2025
#9	-24.61% Jan 4, 2016 - Jun 6, 2016	-4.91% Nov 11, 2025 - Nov 17, 2025
#10	-21.70% Aug 13, 2020 - Oct 27, 2020	-4.32% Jan 23, 2013 - Jan 25, 2013
#11	-13.42% Dec 1, 2015 - Dec 11, 2015	-3.02% Nov 18, 2025 - Nov 24, 2025
#12	-12.79% Mar 1, 2021 - Apr 23, 2021	-1.52% Aug 29, 2025 - Sep 8, 2025
#13	-12.45% Oct 8, 2015 - Nov 13, 2015	-0.59% Aug 22, 2025 - Aug 26, 2025
#14	-12.23% Jan 27, 2026 - Jun 29, 2026	N/A
#15	-11.94% Jun 23, 2017 - Oct 2, 2017	N/A