OSIS vs DNLI

Comparison between OSI Systems Inc (OSIS, Company) and Denali Therapeutics Inc (DNLI, Company).

OSIS is from the Technology sector, while DNLI is from the Healthcare sector.

5-Year PerformanceOSIS has outperformed DNLI, delivering a return of +18.3% compared to -13.7%

OSIS vs DNLI - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	OSIS(COMPANY)	DNLI(COMPANY)
Market Cap	$3.87B	$3.87B
Max Drawdown	88.44%	87.74%
Sharpe Ratio	0.21	1.26
5Y Beta	1.20	1.47
Industry	Electronic Components	Biotechnology
P/E Ratio	25.71	-7.29
Forward P/E	20.28	N/A
PEG Ratio	2.91	-1.14
5Y EPS CAGR	21.46%	N/A
Debt to Equity	112.10%	0.00%
Free Cash Flow Yield	1.73%	-10.89%
P/S Ratio	2.14	3643.65
P/B Ratio	4.36	3.94

Market Cap

Winner

OSIS

$3.87B

DNLI

$3.87B

Max Drawdown

OSIS

88.44%

Winner

DNLI

87.74%

Sharpe Ratio

OSIS

0.21

Winner

DNLI

1.26

5Y Beta

Winner

OSIS

1.20

DNLI

1.47

Industry

OSIS

Electronic Components

DNLI

Biotechnology

P/E Ratio

OSIS

25.71

Winner

DNLI

-7.29

Forward P/E

OSIS

20.28

DNLI

N/A

PEG Ratio

OSIS

2.91

Winner

DNLI

-1.14

5Y EPS CAGR

OSIS

21.46%

DNLI

N/A

Debt to Equity

OSIS

112.10%

Winner

DNLI

0.00%

Free Cash Flow Yield

Winner

OSIS

1.73%

DNLI

-10.89%

P/S Ratio

Winner

OSIS

2.14

DNLI

3643.65

P/B Ratio

OSIS

4.36

Winner

DNLI

3.94

OSIS vs DNLI - Historical Returns

Returns include dividend reinvestment.

Period	OSIS	DNLI
1 month	+8.62%	-4.57%
3 months	+1.83%	+29.86%
6 months	-12.61%	+31.75%
1 year	-0.69%	+91.15%
5 years(CAGR)	+18.27%	-13.75%
10 years(CAGR)	+14.19%	+1.91%
Max(CAGR)	+17.27%	+1.91%

Winner

OSIS

+8.62%

DNLI

-4.57%

OSIS

+1.83%

Winner

DNLI

+29.86%

OSIS

-12.61%

Winner

DNLI

+31.75%

OSIS

-0.69%

Winner

DNLI

+91.15%

5Y(CAGR)

Winner

OSIS

+18.27%

DNLI

-13.75%

10Y(CAGR)

Winner

OSIS

+14.19%

DNLI

+1.91%

Max(CAGR)

Winner

OSIS

+17.27%

DNLI

+1.91%

OSIS vs DNLI - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	OSIS	DNLI
2026	-9.39%	+55.32%
2025	+54.19%	-20.78%
2024	+29.84%	-4.72%
2023	+61.05%	-22.33%
2022	-15.14%	-41.17%
2021	+1.77%	-37.06%
2020	-8.76%	+411.04%
2019	+40.11%	-9.88%
2018	+12.56%	+28.08%
2017	-15.16%	-27.09%
2016	-11.78%	N/A
2015	+25.79%	N/A
2014	+35.57%	N/A
2013	-18.52%	N/A
2012	+29.48%	N/A
2011	+34.12%	N/A
2010	+30.51%	N/A
2009	+89.97%	N/A
2008	-45.94%	N/A
2007	+31.10%	N/A
2006	+12.10%	N/A
2005	-15.45%	N/A
2004	+17.55%	N/A
2003	+9.77%	N/A
2002	-2.41%	N/A
2001	+251.58%	N/A
2000	+13.95%	N/A
1999	+69.23%	N/A

OSIS vs DNLI Drawdown Comparison

The maximum drawdown for OSIS was -88.44%, occurring on Apr 6, 2001. Recovery took 468 trading sessions.

The maximum drawdown for DNLI was -87.74%, occurring on Apr 8, 2025. This drawdown has not yet recovered.

The current OSIS drawdown is -25.22%. The current DNLI drawdown is -72.99%.

Rank	OSIS	DNLI
#1	-88.44% Mar 17, 2000 - Jan 31, 2002	-87.74% Dec 22, 2020 - Apr 8, 2025
#2	-64.03% May 9, 2007 - Jan 8, 2010	-49.76% Feb 16, 2018 - Apr 2, 2019
#3	-53.64% Jul 5, 2019 - May 1, 2023	-49.54% Apr 10, 2019 - Jun 2, 2020
#4	-50.33% Mar 12, 2002 - Feb 26, 2007	-29.88% Dec 8, 2017 - Jan 22, 2018
#5	-48.65% Nov 23, 2015 - Oct 12, 2017	-19.74% Jun 3, 2020 - Aug 6, 2020
#6	-42.98% Oct 12, 2017 - May 1, 2019	-19.58% Jan 29, 2018 - Feb 16, 2018
#7	-41.43% Oct 25, 2012 - Oct 7, 2015	-13.33% Nov 12, 2020 - Dec 4, 2020
#8	-36.15% Apr 17, 2026 - Jun 5, 2026	-11.16% Aug 10, 2020 - Aug 25, 2020
#9	-32.00% Mar 9, 2000 - Mar 17, 2000	-10.43% Sep 17, 2020 - Oct 7, 2020
#10	-28.86% Jul 22, 2011 - Oct 27, 2011	-10.33% Oct 13, 2020 - Oct 27, 2020
#11	-25.97% Jan 11, 2010 - Sep 9, 2010	-9.64% Aug 25, 2020 - Sep 14, 2020
#12	-23.72% Aug 24, 2023 - Feb 9, 2024	-7.28% Oct 28, 2020 - Nov 4, 2020
#13	-20.66% Feb 19, 2025 - May 1, 2025	-3.20% Jan 23, 2018 - Jan 26, 2018
#14	-19.23% Jan 31, 2000 - Feb 22, 2000	-2.37% Apr 3, 2019 - Apr 5, 2019
#15	-18.73% Feb 4, 2002 - Mar 11, 2002	-1.33% Dec 16, 2020 - Dec 18, 2020