OBIO vs AGEN

Comparison between Orchestra BioMed Holdings Inc (OBIO, Company) and Agenus Inc (AGEN, Company).

Both OBIO and AGEN are from the Healthcare sector.

5-Year PerformanceOBIO has outperformed AGEN, delivering a return of -18.3% compared to -43.8%

OBIO vs AGEN - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	OBIO(COMPANY)	AGEN(COMPANY)
Market Cap	$213M	$213M
Max Drawdown	89.40%	99.98%
Sharpe Ratio	0.49	0.36
5Y Beta	1.66	1.12
Industry	Biotechnology	Biotechnology
P/E Ratio	-3.26	3.32
Forward P/E	N/A	2.28
Debt to Equity	36.41%	-27.30%
Free Cash Flow Yield	-25.88%	-41.09%

Market Cap

OBIO

$213M

Winner

AGEN

$213M

Max Drawdown

Winner

OBIO

89.40%

AGEN

99.98%

Sharpe Ratio

Winner

OBIO

0.49

AGEN

0.36

5Y Beta

OBIO

1.66

Winner

AGEN

1.12

Industry

OBIO

Biotechnology

AGEN

Biotechnology

P/E Ratio

Winner

OBIO

-3.26

AGEN

3.32

Forward P/E

OBIO

N/A

AGEN

2.28

Debt to Equity

OBIO

36.41%

Winner

AGEN

-27.30%

Free Cash Flow Yield

Winner

OBIO

-25.88%

AGEN

-41.09%

OBIO vs AGEN - Historical Returns

Returns include dividend reinvestment.

Period	OBIO	AGEN
1 month	-9.90%	+101.63%
3 months	-12.29%	+64.63%
6 months	-9.90%	+91.05%
1 year	+14.11%	+1.98%
5 years(CAGR)	-18.30%	-43.79%
10 years(CAGR)	N/A	-23.80%
Max(CAGR)	-17.42%	-22.61%

OBIO

-9.90%

Winner

AGEN

+101.63%

OBIO

-12.29%

Winner

AGEN

+64.63%

OBIO

-9.90%

Winner

AGEN

+91.05%

Winner

OBIO

+14.11%

AGEN

+1.98%

5Y(CAGR)

Winner

OBIO

-18.30%

AGEN

-43.79%

10Y(CAGR)

OBIO

N/A

AGEN

-23.80%

Max(CAGR)

Winner

OBIO

-17.42%

AGEN

-22.61%

OBIO vs AGEN - Annual Returns (2000 - 2026)

Returns include dividend reinvestment.

Year	OBIO	AGEN
2026	-15.55%	+91.64%
2025	-22.86%	+1.62%
2024	-54.44%	-82.88%
2023	-9.06%	-64.85%
2022	+0.71%	-30.84%
2021	-22.46%	-0.31%
2020	+12.37%	-21.29%
2019	N/A	+62.15%
2018	N/A	-32.77%
2017	N/A	-21.63%
2016	N/A	-7.62%
2015	N/A	+14.07%
2014	N/A	+42.81%
2013	N/A	-37.74%
2012	N/A	+88.94%
2011	N/A	-68.55%
2010	N/A	+57.17%
2009	N/A	+33.33%
2008	N/A	-76.92%
2007	N/A	+6.25%
2006	N/A	-61.80%
2005	N/A	-52.40%
2004	N/A	-11.69%
2003	N/A	+5.98%
2002	N/A	-33.89%
2001	N/A	+48.28%
2000	N/A	-76.09%

OBIO vs AGEN Drawdown Comparison

The maximum drawdown for OBIO was -89.40%, occurring on Sep 23, 2025. This drawdown has not yet recovered.

The maximum drawdown for AGEN was -99.98%, occurring on Mar 31, 2025. This drawdown has not yet recovered.

The current OBIO drawdown is -83.59%. The current AGEN drawdown is -99.90%.

Rank	OBIO	AGEN
#1	-89.40% Apr 12, 2023 - Sep 23, 2025	-99.98% Mar 9, 2000 - Mar 31, 2025
#2	-42.60% Feb 16, 2021 - Mar 6, 2023	-23.90% Feb 16, 2000 - Mar 9, 2000
#3	-33.00% Mar 6, 2023 - Mar 31, 2023	-6.50% Feb 10, 2000 - Feb 15, 2000
#4	-14.37% Aug 6, 2020 - Dec 30, 2020	-4.86% Feb 8, 2000 - Feb 10, 2000
#5	-13.31% Dec 30, 2020 - Feb 8, 2021	N/A
#6	-5.52% Mar 31, 2023 - Apr 5, 2023	N/A
#7	-1.63% Apr 5, 2023 - Apr 11, 2023	N/A
#8	-0.53% Feb 8, 2021 - Feb 10, 2021	N/A