NBIX vs IREN

Comparison between Neurocrine Biosciences Inc (NBIX, Company) and Iris Energy Ltd (IREN, Company).

NBIX is from the Healthcare sector, while IREN is from the Financial Services sector.

5-Year PerformanceIREN has outperformed NBIX, delivering a return of +15.6% compared to +10.4%

NBIX vs IREN - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	NBIX(COMPANY)	IREN(COMPANY)
Market Cap	$17B	$17B
Max Drawdown	97.21%	95.73%
Sharpe Ratio	0.83	1.86
5Y Beta	0.80	2.73
Industry	Drug Manufacturers - Specialty & Generic	Capital Markets
P/E Ratio	24.82	606.41
Forward P/E	23.42	136.99
PEG Ratio	0.21	4.05
5Y EPS CAGR	9.25%	N/A
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	4.95%	-8.70%
P/S Ratio	5.38	22.99
P/B Ratio	4.90	6.75

Market Cap

NBIX

$17B

Winner

IREN

$17B

Max Drawdown

NBIX

97.21%

Winner

IREN

95.73%

Sharpe Ratio

NBIX

0.83

Winner

IREN

1.86

5Y Beta

Winner

NBIX

0.80

IREN

2.73

Industry

NBIX

Drug Manufacturers - Specialty & Generic

IREN

Capital Markets

P/E Ratio

Winner

NBIX

24.82

IREN

606.41

Forward P/E

Winner

NBIX

23.42

IREN

136.99

PEG Ratio

Winner

NBIX

0.21

IREN

4.05

5Y EPS CAGR

NBIX

9.25%

IREN

N/A

Debt to Equity

NBIX

0.00%

IREN

0.00%

Free Cash Flow Yield

Winner

NBIX

4.95%

IREN

-8.70%

P/S Ratio

Winner

NBIX

5.38

IREN

22.99

P/B Ratio

Winner

NBIX

4.90

IREN

6.75

NBIX vs IREN - Historical Returns

Returns include dividend reinvestment.

Period	NBIX	IREN
1 month	+5.43%	-20.14%
3 months	+25.20%	+15.23%
6 months	+11.74%	+13.72%
1 year	+28.49%	+302.19%
5 years(CAGR)	+10.36%	+15.65%
10 years(CAGR)	+14.26%	N/A
Max(CAGR)	+12.57%	+15.65%

Winner

NBIX

+5.43%

IREN

-20.14%

Winner

NBIX

+25.20%

IREN

+15.23%

NBIX

+11.74%

Winner

IREN

+13.72%

NBIX

+28.49%

Winner

IREN

+302.19%

5Y(CAGR)

NBIX

+10.36%

Winner

IREN

+15.65%

10Y(CAGR)

NBIX

+14.26%

IREN

N/A

Max(CAGR)

NBIX

+12.57%

Winner

IREN

+15.65%

NBIX vs IREN - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	NBIX	IREN
2026	+16.77%	+11.80%
2025	+2.88%	+261.09%
2024	+3.62%	+44.41%
2023	+9.73%	+500.84%
2022	+35.01%	-91.79%
2021	-11.16%	-33.87%
2020	-11.50%	N/A
2019	+53.36%	N/A
2018	-9.95%	N/A
2017	+100.70%	N/A
2016	-26.07%	N/A
2015	+147.68%	N/A
2014	+133.93%	N/A
2013	+14.74%	N/A
2012	-12.51%	N/A
2011	+10.82%	N/A
2010	+184.01%	N/A
2009	-16.82%	N/A
2008	-29.20%	N/A
2007	-55.79%	N/A
2006	-83.61%	N/A
2005	+27.97%	N/A
2004	-11.17%	N/A
2003	+20.11%	N/A
2002	-9.71%	N/A
2001	+59.40%	N/A
2000	+31.89%	N/A
1999	+253.57%	N/A

NBIX vs IREN Drawdown Comparison

The maximum drawdown for NBIX was -97.21%, occurring on Nov 12, 2009. Recovery took 2931 trading sessions.

The maximum drawdown for IREN was -95.73%, occurring on Dec 28, 2022. Recovery took 946 trading sessions.

The current NBIX drawdown is -1.89%. The current IREN drawdown is -37.52%.

Rank	NBIX	IREN
#1	-97.21% Mar 15, 2006 - Nov 2, 2017	-95.73% Nov 19, 2021 - Aug 29, 2025
#2	-66.15% Mar 3, 2000 - Nov 20, 2001	-58.62% Nov 5, 2025 - Mar 30, 2026
#3	-54.12% Dec 24, 2001 - Jun 5, 2003	-25.49% Oct 14, 2025 - Nov 5, 2025
#4	-50.71% Apr 27, 2004 - Feb 27, 2006	-11.20% Sep 24, 2025 - Oct 3, 2025
#5	-46.39% Jul 15, 2020 - Jan 17, 2024	-10.24% Sep 2, 2025 - Sep 9, 2025
#6	-45.71% Sep 4, 2018 - Jun 19, 2020	-6.39% Oct 9, 2025 - Oct 13, 2025
#7	-42.89% Jan 30, 2025 - Nov 5, 2025	-4.29% Nov 17, 2021 - Nov 19, 2021
#8	-28.57% Jan 21, 2000 - Feb 16, 2000	-4.17% Sep 17, 2025 - Sep 19, 2025
#9	-27.12% Aug 1, 2024 - Jan 30, 2025	-2.58% Oct 7, 2025 - Oct 9, 2025
#10	-22.86% Dec 2, 1999 - Dec 13, 1999	-2.32% Sep 10, 2025 - Sep 12, 2025
#11	-21.32% Jun 16, 2003 - Jan 23, 2004	-1.86% Sep 15, 2025 - Sep 17, 2025
#12	-20.90% Dec 10, 2025 - May 12, 2026	-0.31% Sep 22, 2025 - Sep 24, 2025
#13	-19.01% Dec 29, 1999 - Jan 10, 2000	N/A
#14	-18.53% Mar 9, 2018 - May 15, 2018	N/A
#15	-13.74% Jan 26, 2004 - Mar 4, 2004	N/A