NBIX vs ASND

Comparison between Neurocrine Biosciences Inc (NBIX, Company) and Ascendis Pharma A/S (ASND, Company).

Both NBIX and ASND are from the Healthcare sector.

5-Year PerformanceASND has outperformed NBIX, delivering a return of +16.5% compared to +12.3%

NBIX vs ASND - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	NBIX(COMPANY)	ASND(COMPANY)
Market Cap	$18B	$18B
Max Drawdown	97.21%	61.72%
Sharpe Ratio	1.10	1.30
5Y Beta	0.79	0.45
Industry	Drug Manufacturers - Specialty & Generic	Biotechnology
P/E Ratio	26.64	31.05
Forward P/E	24.57	17.33
PEG Ratio	0.22	N/A
5Y EPS CAGR	9.25%	N/A
Debt to Equity	0.00%	183.75%
Free Cash Flow Yield	4.61%	0.28%
P/S Ratio	5.78	21.00
P/B Ratio	5.13	32.72

Market Cap

Winner

NBIX

$18B

ASND

$18B

Max Drawdown

NBIX

97.21%

Winner

ASND

61.72%

Sharpe Ratio

NBIX

1.10

Winner

ASND

1.30

5Y Beta

NBIX

0.79

Winner

ASND

0.45

Industry

NBIX

Drug Manufacturers - Specialty & Generic

ASND

Biotechnology

P/E Ratio

Winner

NBIX

26.64

ASND

31.05

Forward P/E

NBIX

24.57

Winner

ASND

17.33

PEG Ratio

NBIX

0.22

ASND

N/A

5Y EPS CAGR

NBIX

9.25%

ASND

N/A

Debt to Equity

Winner

NBIX

0.00%

ASND

183.75%

Free Cash Flow Yield

Winner

NBIX

4.61%

ASND

0.28%

P/S Ratio

Winner

NBIX

5.78

ASND

21.00

P/B Ratio

Winner

NBIX

5.13

ASND

32.72

NBIX vs ASND - Historical Returns

Returns include dividend reinvestment.

Period	NBIX	ASND
1 month	+10.10%	+28.91%
3 months	+37.41%	+13.03%
6 months	+30.43%	+33.23%
1 year	+31.27%	+53.24%
5 years(CAGR)	+12.32%	+16.49%
10 years(CAGR)	+13.80%	+35.61%
Max(CAGR)	+12.87%	+26.21%

NBIX

+10.10%

Winner

ASND

+28.91%

Winner

NBIX

+37.41%

ASND

+13.03%

NBIX

+30.43%

Winner

ASND

+33.23%

NBIX

+31.27%

Winner

ASND

+53.24%

5Y(CAGR)

NBIX

+12.32%

Winner

ASND

+16.49%

10Y(CAGR)

NBIX

+13.80%

Winner

ASND

+35.61%

Max(CAGR)

NBIX

+12.87%

Winner

ASND

+26.21%

NBIX vs ASND - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	NBIX	ASND
2026	+25.97%	+26.80%
2025	+2.88%	+54.52%
2024	+3.62%	+7.95%
2023	+9.73%	+4.33%
2022	+35.01%	-10.03%
2021	-11.16%	-18.71%
2020	-11.50%	+18.17%
2019	+53.36%	+114.56%
2018	-9.95%	+57.41%
2017	+100.70%	+101.21%
2016	-26.07%	+12.26%
2015	+147.68%	-2.71%
2014	+133.93%	N/A
2013	+14.74%	N/A
2012	-12.51%	N/A
2011	+10.82%	N/A
2010	+184.01%	N/A
2009	-16.82%	N/A
2008	-29.20%	N/A
2007	-55.79%	N/A
2006	-83.61%	N/A
2005	+27.97%	N/A
2004	-11.17%	N/A
2003	+20.11%	N/A
2002	-9.71%	N/A
2001	+59.40%	N/A
2000	+31.89%	N/A
1999	+253.57%	N/A

NBIX vs ASND Drawdown Comparison

The maximum drawdown for NBIX was -97.21%, occurring on Nov 12, 2009. Recovery took 2931 trading sessions.

The maximum drawdown for ASND was -61.72%, occurring on Apr 28, 2023. Recovery took 1163 trading sessions.

The current NBIX drawdown is -1.91%. The current ASND drawdown is -2.43%.

Rank	NBIX	ASND
#1	-97.21% Mar 15, 2006 - Nov 2, 2017	-61.72% Dec 14, 2020 - Aug 4, 2025
#2	-66.15% Mar 3, 2000 - Nov 20, 2001	-42.92% Jul 16, 2015 - Feb 1, 2017
#3	-54.12% Dec 24, 2001 - Jun 5, 2003	-33.15% Feb 20, 2020 - May 20, 2020
#4	-50.71% Apr 27, 2004 - Feb 27, 2006	-30.77% Jun 3, 2019 - Dec 26, 2019
#5	-46.39% Jul 15, 2020 - Jan 17, 2024	-27.69% Aug 27, 2018 - Mar 4, 2019
#6	-45.71% Sep 4, 2018 - Jun 19, 2020	-24.67% Mar 2, 2017 - Sep 22, 2017
#7	-42.89% Jan 30, 2025 - Nov 5, 2025	-24.09% Apr 23, 2015 - Jul 15, 2015
#8	-28.57% Jan 21, 2000 - Feb 16, 2000	-17.62% Apr 14, 2026 - Jun 25, 2026
#9	-27.12% Aug 1, 2024 - Jan 30, 2025	-17.60% Mar 13, 2019 - Jun 3, 2019
#10	-22.86% Dec 2, 1999 - Dec 13, 1999	-13.95% Mar 12, 2018 - May 25, 2018
#11	-21.32% Jun 16, 2003 - Jan 23, 2004	-13.92% Jun 23, 2020 - Oct 2, 2020
#12	-20.90% Dec 10, 2025 - May 12, 2026	-13.85% Oct 2, 2017 - Dec 5, 2017
#13	-19.01% Dec 29, 1999 - Jan 10, 2000	-13.50% Nov 4, 2020 - Dec 8, 2020
#14	-18.53% Mar 9, 2018 - May 15, 2018	-13.25% Jan 29, 2015 - Apr 21, 2015
#15	-13.74% Jan 26, 2004 - Mar 4, 2004	-12.96% May 29, 2018 - Aug 24, 2018