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MLYS vs SPY

Comparison between Mineralys Therapeutics Inc (MLYS, Company) and SPDR S&P 500 ETF Trust (SPY, ETF).

MLYS vs SPY - Performance Comparison

Key Characteristics

Financial metrics and valuation ratios

Market Cap / Net Assets
MLYS
$2.41B
Winner
SPY
$781B
Expense Ratio
MLYS
N/A
SPY
0.09%
Max Drawdown
MLYS
68.86%
Winner
SPY
56.47%
Sharpe Ratio
MLYS
1.03
Winner
SPY
1.12
5Y Beta
Winner
MLYS
0.78
SPY
1.00
Industry
MLYS
Biotechnology
SPY
N/A
P/E Ratio
Winner
MLYS
-14.60
SPY
28.53
Forward P/E
MLYS
N/A
SPY
21.47
5Y Dividends CAGR
MLYS
N/A
SPY
6.00%
5Y EPS CAGR
MLYS
N/A
SPY
25.58%
Debt to Equity
Winner
MLYS
0.00%
SPY
32.09%
Free Cash Flow Yield
MLYS
-5.67%
SPY
N/A
P/S Ratio
MLYS
N/A
SPY
3.75
P/B Ratio
Winner
MLYS
3.80
SPY
5.64

MLYS vs SPY - Historical Returns

Returns include dividend reinvestment.

1M
Winner
MLYS
+5.43%
SPY
+0.63%
3M
MLYS
-5.23%
Winner
SPY
+4.46%
6M
MLYS
-17.63%
Winner
SPY
+7.67%
1Y
Winner
MLYS
+102.85%
SPY
+17.68%
5Y(CAGR)
MLYS
N/A
SPY
+12.42%
10Y(CAGR)
MLYS
N/A
SPY
+14.84%
Max(CAGR)
Winner
MLYS
+11.70%
SPY
+8.44%

MLYS vs SPY - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

YearMLYSSPY
2026-24.39%+8.63%
2025+196.24%+18.00%
2024+41.82%+25.59%
2023-53.36%+26.72%
2022N/A-18.64%
2021N/A+30.52%
2020N/A+17.28%
2019N/A+31.09%
2018N/A-5.24%
2017N/A+20.78%
2016N/A+13.59%
2015N/A+1.31%
2014N/A+14.56%
2013N/A+29.00%
2012N/A+14.17%
2011N/A+0.85%
2010N/A+13.14%
2009N/A+22.67%
2008N/A-36.25%
2007N/A+5.32%
2006N/A+13.85%
2005N/A+5.32%
2004N/A+10.75%
2003N/A+24.18%
2002N/A-22.42%
2001N/A-10.13%
2000N/A-8.84%
1999N/A+8.61%

MLYS vs SPY Drawdown Comparison

The maximum drawdown for MLYS was -68.86%, occurring on Nov 22, 2023. Recovery took 626 trading sessions.

The maximum drawdown for SPY was -55.20%, occurring on Mar 9, 2009. Recovery took 1224 trading sessions.

The current MLYS drawdown is -42.95%. The current SPY drawdown is -2.57%.

RankMLYSSPY
#1-68.86%
Mar 3, 2023 - Sep 2, 2025		-55.20%
Oct 9, 2007 - Aug 16, 2012
#2-52.46%
Nov 12, 2025 - Jun 8, 2026		-47.50%
Mar 24, 2000 - Oct 26, 2006
#3-16.19%
Oct 20, 2025 - Nov 10, 2025		-33.70%
Feb 19, 2020 - Aug 10, 2020
#4-7.61%
Feb 13, 2023 - Mar 3, 2023		-24.50%
Jan 3, 2022 - Dec 13, 2023
#5-7.35%
Oct 2, 2025 - Oct 10, 2025		-19.34%
Sep 20, 2018 - Apr 12, 2019
#6-6.09%
Sep 10, 2025 - Sep 18, 2025		-18.76%
Feb 19, 2025 - Jun 26, 2025
#7-5.57%
Sep 18, 2025 - Sep 26, 2025		-13.02%
Jul 20, 2015 - Apr 18, 2016
#8-5.18%
Sep 26, 2025 - Oct 2, 2025		-10.10%
Jan 26, 2018 - Aug 6, 2018
#9-0.88%
Oct 15, 2025 - Oct 17, 2025		-9.44%
Sep 2, 2020 - Nov 11, 2020
#10-0.58%
Oct 13, 2025 - Oct 15, 2025		-9.30%
Jan 19, 2000 - Mar 17, 2000
#11N/A-9.05%
Jul 19, 2007 - Oct 5, 2007
#12N/A-8.88%
Jan 27, 2026 - Apr 14, 2026
#13N/A-8.41%
Jul 16, 2024 - Sep 19, 2024
#14N/A-7.35%
Sep 14, 2012 - Jan 2, 2013
#15N/A-7.27%
Sep 18, 2014 - Oct 31, 2014

Correlation

Correlation between MLYS and SPY is 0.70 which considered as a moderate positive correlation - the stocks show some tendency to move together.

0.70
-101

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