MESO vs AVDL

Comparison between Mesoblast Ltd (MESO, Company) and Avadel Pharmaceuticals plc (AVDL, Company).

Both MESO and AVDL are from the Healthcare sector.

5-Year PerformanceAVDL has outperformed MESO, delivering a return of +19.2% compared to +2.1%

MESO vs AVDL - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	MESO(COMPANY)	AVDL(COMPANY)
Market Cap	$2.11B	$2.10B
Max Drawdown	95.66%	97.50%
Sharpe Ratio	0.33	2.00
5Y Beta	1.38	N/A
Industry	Biotechnology	Drug Manufacturers - Specialty & Generic
P/E Ratio	-22.13	-7003.97
Forward P/E	454.55	16.86
PEG Ratio	0.00	N/A
5Y EPS CAGR	-15.82%	N/A
Debt to Equity	23.52%	0.00%
Free Cash Flow Yield	-2.48%	1.63%
P/S Ratio	32.33	N/A
P/B Ratio	3.71	N/A

Market Cap

Winner

MESO

$2.11B

AVDL

$2.10B

Max Drawdown

Winner

MESO

95.66%

AVDL

97.50%

Sharpe Ratio

MESO

0.33

Winner

AVDL

2.00

5Y Beta

MESO

1.38

AVDL

N/A

Industry

MESO

Biotechnology

AVDL

Drug Manufacturers - Specialty & Generic

P/E Ratio

MESO

-22.13

Winner

AVDL

-7003.97

Forward P/E

MESO

454.55

Winner

AVDL

16.86

PEG Ratio

MESO

0.00

AVDL

N/A

5Y EPS CAGR

MESO

-15.82%

AVDL

N/A

Debt to Equity

MESO

23.52%

Winner

AVDL

0.00%

Free Cash Flow Yield

MESO

-2.48%

Winner

AVDL

1.63%

P/S Ratio

MESO

32.33

AVDL

N/A

P/B Ratio

MESO

3.71

AVDL

N/A

MESO vs AVDL - Historical Returns

Returns include dividend reinvestment.

Period	MESO	AVDL
1 month	+4.55%	+0.65%
3 months	+3.74%	+13.00%
6 months	-12.51%	+61.49%
1 year	-0.06%	+142.87%
5 years(CAGR)	+2.06%	+19.21%
10 years(CAGR)	+6.61%	+9.11%
Max(CAGR)	-0.08%	+8.77%

Winner

MESO

+4.55%

AVDL

+0.65%

MESO

+3.74%

Winner

AVDL

+13.00%

MESO

-12.51%

Winner

AVDL

+61.49%

MESO

-0.06%

Winner

AVDL

+142.87%

5Y(CAGR)

MESO

+2.06%

Winner

AVDL

+19.21%

10Y(CAGR)

MESO

+6.61%

Winner

AVDL

+9.11%

Max(CAGR)

MESO

-0.08%

Winner

AVDL

+8.77%

MESO vs AVDL - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	MESO	AVDL
2026	-11.45%	+0.56%
2025	-12.47%	+95.91%
2024	+816.67%	-26.40%
2023	-62.59%	+101.71%
2022	-41.57%	-13.63%
2021	-43.60%	+21.32%
2020	+8.43%	-9.85%
2019	+64.14%	+171.58%
2018	-29.45%	-70.68%
2017	+8.15%	-25.11%
2016	-13.43%	-19.58%
2015	-21.58%	-28.55%
2014	N/A	+110.18%
2013	N/A	+147.69%
2012	N/A	-41.62%
2011	N/A	-25.25%
2010	N/A	-9.16%
2009	N/A	+75.27%
2008	N/A	-63.19%
2007	N/A	-68.54%
2006	N/A	+61.89%
2005	N/A	-3.92%
2004	N/A	-28.24%
2003	N/A	+561.48%
2002	N/A	+60.58%
2001	N/A	-58.56%
2000	N/A	+231.05%
1999	N/A	-10.53%

MESO vs AVDL Drawdown Comparison

The maximum drawdown for MESO was -95.66%, occurring on Jan 18, 2024. This drawdown has not yet recovered.

The maximum drawdown for AVDL was -97.50%, occurring on May 26, 2022. This drawdown has not yet recovered.

The current MESO drawdown is -59.41%. The current AVDL drawdown is -49.50%.

Rank	MESO	AVDL
#1	-95.66% Aug 17, 2020 - Jan 18, 2024	-97.50% Sep 19, 2003 - May 26, 2022
#2	-72.61% Apr 26, 2017 - Apr 24, 2020	-91.74% Mar 1, 2000 - Jun 4, 2003
#3	-66.41% Mar 17, 2016 - Apr 11, 2017	-60.00% Nov 12, 1999 - Dec 9, 1999
#4	-46.24% Nov 13, 2015 - Mar 2, 2016	-28.57% Dec 9, 1999 - Jan 18, 2000
#5	-34.96% Aug 10, 2020 - Aug 14, 2020	-26.72% Feb 18, 2000 - Feb 29, 2000
#6	-34.82% Apr 24, 2020 - Aug 5, 2020	-26.12% Jul 25, 2003 - Aug 27, 2003
#7	-16.68% Mar 2, 2016 - Mar 17, 2016	-25.00% Jan 18, 2000 - Feb 10, 2000
#8	-3.53% Apr 20, 2017 - Apr 25, 2017	-9.84% Jun 5, 2003 - Jun 23, 2003
#9	-3.06% Apr 11, 2017 - Apr 18, 2017	-7.41% Feb 11, 2000 - Feb 16, 2000
#10	-1.46% Aug 5, 2020 - Aug 7, 2020	-6.59% Jun 27, 2003 - Jul 3, 2003
#11	-0.80% Apr 18, 2017 - Apr 20, 2017	-5.26% Nov 1, 1999 - Nov 12, 1999
#12	N/A	-4.68% Jul 16, 2003 - Jul 22, 2003
#13	N/A	-2.85% Aug 28, 2003 - Sep 2, 2003
#14	N/A	-2.03% Sep 9, 2003 - Sep 12, 2003
#15	N/A	-1.54% Sep 3, 2003 - Sep 8, 2003