MDGL vs SAIA

Comparison between Madrigal Pharmaceuticals Inc (MDGL, Company) and Saia Inc (SAIA, Company).

MDGL is from the Healthcare sector, while SAIA is from the Industrials sector.

5-Year PerformanceMDGL has outperformed SAIA, delivering a return of +36.9% compared to +16.5%

MDGL vs SAIA - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	MDGL(COMPANY)	SAIA(COMPANY)
Market Cap	$12B	$12B
Max Drawdown	98.40%	80.35%
Sharpe Ratio	1.44	1.21
5Y Beta	0.73	1.44
Industry	Biotechnology	Trucking
P/E Ratio	-37.21	45.45
Forward P/E	666.67	37.31
5Y EPS CAGR	23.26%	11.22%
Debt to Equity	62.62%	4.26%
Free Cash Flow Yield	-2.34%	1.68%

Market Cap

Winner

MDGL

$12B

SAIA

$12B

Max Drawdown

MDGL

98.40%

Winner

SAIA

80.35%

Sharpe Ratio

Winner

MDGL

1.44

SAIA

1.21

5Y Beta

Winner

MDGL

0.73

SAIA

1.44

Industry

MDGL

Biotechnology

SAIA

Trucking

P/E Ratio

Winner

MDGL

-37.21

SAIA

45.45

Forward P/E

MDGL

666.67

Winner

SAIA

37.31

5Y EPS CAGR

Winner

MDGL

23.26%

SAIA

11.22%

Debt to Equity

MDGL

62.62%

Winner

SAIA

4.26%

Free Cash Flow Yield

MDGL

-2.34%

Winner

SAIA

1.68%

MDGL vs SAIA - Historical Returns

Returns include dividend reinvestment.

Period	MDGL	SAIA
1 month	-3.16%	-5.06%
3 months	+14.42%	+34.87%
6 months	-7.10%	+32.24%
1 year	+78.89%	+67.05%
5 years(CAGR)	+36.90%	+16.53%
10 years(CAGR)	+45.48%	+32.61%
Max(CAGR)	+2.42%	+17.77%

Winner

MDGL

-3.16%

SAIA

-5.06%

MDGL

+14.42%

Winner

SAIA

+34.87%

MDGL

-7.10%

Winner

SAIA

+32.24%

Winner

MDGL

+78.89%

SAIA

+67.05%

5Y(CAGR)

Winner

MDGL

+36.90%

SAIA

+16.53%

10Y(CAGR)

Winner

MDGL

+45.48%

SAIA

+32.61%

Max(CAGR)

MDGL

+2.42%

Winner

SAIA

+17.77%

MDGL vs SAIA - Annual Returns (2002 - 2026)

Returns include dividend reinvestment.

Year	MDGL	SAIA
2026	-14.84%	+29.05%
2025	+85.59%	-26.68%
2024	+36.02%	+6.60%
2023	-18.93%	+110.07%
2022	+222.07%	-33.39%
2021	-22.80%	+87.31%
2020	+22.60%	+92.77%
2019	-18.06%	+70.74%
2018	+15.71%	-21.93%
2017	+475.13%	+57.57%
2016	+28.97%	+102.62%
2015	-87.74%	-60.06%
2014	-49.62%	+81.39%
2013	-45.64%	+104.14%
2012	+84.46%	+76.09%
2011	-24.56%	-25.36%
2010	+10.87%	+15.45%
2009	-17.99%	+31.73%
2008	-3.62%	-14.82%
2007	-26.29%	-43.95%
2006	N/A	+4.08%
2005	N/A	-7.29%
2004	N/A	+34.62%
2003	N/A	+73.03%
2002	N/A	-25.93%

MDGL vs SAIA Drawdown Comparison

The maximum drawdown for MDGL was -98.40%, occurring on Feb 11, 2016. Recovery took 3162 trading sessions.

The maximum drawdown for SAIA was -80.35%, occurring on Nov 20, 2008. Recovery took 1612 trading sessions.

The current MDGL drawdown is -16.10%. The current SAIA drawdown is -28.19%.

Rank	MDGL	SAIA
#1	-98.40% Jan 28, 2013 - Aug 22, 2025	-80.35% Oct 16, 2006 - Mar 14, 2013
#2	-87.64% Oct 5, 2007 - Jan 22, 2013	-65.82% Dec 4, 2014 - Aug 31, 2017
#3	-51.43% Jun 4, 2007 - Oct 4, 2007	-60.94% Mar 6, 2024 - Apr 29, 2025
#4	-29.36% Dec 22, 2025 - Mar 3, 2026	-53.15% Nov 17, 2021 - Jul 17, 2023
#5	-18.88% Feb 9, 2007 - Jun 4, 2007	-49.18% Sep 12, 2002 - Jul 2, 2003
#6	-10.10% Sep 30, 2025 - Nov 5, 2025	-44.51% Jun 23, 2004 - Jan 25, 2006
#7	-9.42% Nov 26, 2025 - Dec 22, 2025	-39.57% Jun 12, 2018 - Sep 4, 2019
#8	-8.01% Sep 8, 2025 - Sep 30, 2025	-39.00% Oct 28, 2019 - May 26, 2020
#9	-4.91% Nov 11, 2025 - Nov 17, 2025	-24.09% Mar 15, 2006 - Aug 16, 2006
#10	-4.32% Jan 23, 2013 - Jan 25, 2013	-21.51% Sep 1, 2023 - Dec 21, 2023
#11	-3.02% Nov 18, 2025 - Nov 24, 2025	-21.10% May 7, 2021 - Aug 11, 2021
#12	-1.52% Aug 29, 2025 - Sep 8, 2025	-19.00% Sep 22, 2003 - Dec 2, 2003
#13	-0.59% Aug 22, 2025 - Aug 26, 2025	-18.30% Jul 11, 2013 - Oct 22, 2013
#14	N/A	-17.02% Jan 25, 2018 - May 21, 2018
#15	N/A	-14.17% Oct 22, 2013 - Mar 4, 2014