MDGL vs KNX

Comparison between Madrigal Pharmaceuticals Inc (MDGL, Company) and Knight-Swift Transportation Holdings Inc - Class A (KNX, Company).

MDGL is from the Healthcare sector, while KNX is from the Industrials sector.

5-Year PerformanceMDGL has outperformed KNX, delivering a return of +43.7% compared to +9.7%

MDGL vs KNX - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	MDGL(COMPANY)	KNX(COMPANY)
Market Cap	$12B	$12B
Max Drawdown	98.40%	69.70%
Sharpe Ratio	1.45	1.30
5Y Beta	0.77	1.08
Industry	Biotechnology	Trucking
P/E Ratio	-39.55	362.91
Forward P/E	666.67	36.50
PEG Ratio	0.00	0.64
Dividend Yield	N/A	1.05%
5Y Dividends CAGR	N/A	22.55%
5Y EPS CAGR	23.26%	-40.58%
Debt to Equity	62.62%	24.85%
Free Cash Flow Yield	-2.21%	10.52%
P/S Ratio	10.95	1.65
P/B Ratio	23.20	1.77

Market Cap

Winner

MDGL

$12B

KNX

$12B

Max Drawdown

MDGL

98.40%

Winner

KNX

69.70%

Sharpe Ratio

Winner

MDGL

1.45

KNX

1.30

5Y Beta

Winner

MDGL

0.77

KNX

1.08

Industry

MDGL

Biotechnology

KNX

Trucking

P/E Ratio

Winner

MDGL

-39.55

KNX

362.91

Forward P/E

MDGL

666.67

Winner

KNX

36.50

PEG Ratio

Winner

MDGL

0.00

KNX

0.64

Dividend Yield

MDGL

N/A

KNX

1.05%

5Y Dividends CAGR

MDGL

N/A

KNX

22.55%

5Y EPS CAGR

Winner

MDGL

23.26%

KNX

-40.58%

Debt to Equity

MDGL

62.62%

Winner

KNX

24.85%

Free Cash Flow Yield

MDGL

-2.21%

Winner

KNX

10.52%

P/S Ratio

MDGL

10.95

Winner

KNX

1.65

P/B Ratio

MDGL

23.20

Winner

KNX

1.77

MDGL vs KNX - Historical Returns

Returns include dividend reinvestment.

Period	MDGL	KNX
1 month	+6.82%	-2.71%
3 months	+6.27%	+11.47%
6 months	+13.33%	+28.07%
1 year	+82.01%	+61.35%
5 years(CAGR)	+43.73%	+9.66%
10 years(CAGR)	+48.94%	+10.79%
Max(CAGR)	+2.80%	+14.27%

Winner

MDGL

+6.82%

KNX

-2.71%

MDGL

+6.27%

Winner

KNX

+11.47%

MDGL

+13.33%

Winner

KNX

+28.07%

Winner

MDGL

+82.01%

KNX

+61.35%

5Y(CAGR)

Winner

MDGL

+43.73%

KNX

+9.66%

10Y(CAGR)

Winner

MDGL

+48.94%

KNX

+10.79%

Max(CAGR)

MDGL

+2.80%

Winner

KNX

+14.27%

MDGL vs KNX - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	MDGL	KNX
2026	-8.31%	+39.64%
2025	+85.59%	+0.70%
2024	+36.02%	-6.49%
2023	-18.93%	+9.76%
2022	+222.07%	-12.67%
2021	-22.80%	+50.13%
2020	+22.60%	+13.98%
2019	-18.06%	+39.72%
2018	+15.71%	-43.43%
2017	+475.13%	+31.17%
2016	+28.97%	+39.54%
2015	-87.74%	-27.51%
2014	-49.62%	+87.93%
2013	-45.64%	+22.74%
2012	+84.46%	-2.37%
2011	-24.56%	-18.22%
2010	+10.87%	+4.05%
2009	-17.99%	+20.25%
2008	-3.62%	+11.17%
2007	-26.29%	-14.54%
2006	N/A	-18.02%
2005	N/A	+27.24%
2004	N/A	+42.65%
2003	N/A	+21.45%
2002	N/A	+10.58%
2001	N/A	+116.69%
2000	N/A	+15.34%
1999	N/A	+24.58%

MDGL vs KNX Drawdown Comparison

The maximum drawdown for MDGL was -98.40%, occurring on Feb 11, 2016. Recovery took 3162 trading sessions.

The maximum drawdown for KNX was -67.98%, occurring on Oct 6, 2011. Recovery took 799 trading sessions.

The current MDGL drawdown is -9.67%. The current KNX drawdown is -12.07%.

Rank	MDGL	KNX
#1	-98.40% Jan 28, 2013 - Aug 22, 2025	-67.98% Jul 26, 2010 - Sep 26, 2013
#2	-87.64% Oct 5, 2007 - Jan 22, 2013	-51.57% Mar 16, 2018 - Mar 30, 2021
#3	-51.43% Jun 4, 2007 - Oct 4, 2007	-46.91% Mar 20, 2015 - Nov 14, 2016
#4	-29.36% Dec 22, 2025 - Mar 3, 2026	-42.78% Nov 23, 2005 - Apr 19, 2010
#5	-18.88% Feb 9, 2007 - Jun 4, 2007	-38.04% Feb 2, 2023 - Feb 20, 2026
#6	-10.10% Sep 30, 2025 - Nov 5, 2025	-36.78% Jan 30, 2002 - Apr 25, 2003
#7	-9.42% Nov 26, 2025 - Dec 22, 2025	-32.24% Jul 17, 2001 - Oct 23, 2001
#8	-8.01% Sep 8, 2025 - Sep 30, 2025	-28.80% Dec 29, 2021 - Feb 2, 2023
#9	-4.91% Nov 11, 2025 - Nov 17, 2025	-25.74% Apr 25, 2000 - Dec 28, 2000
#10	-4.32% Jan 23, 2013 - Jan 25, 2013	-25.48% Feb 7, 2001 - Apr 9, 2001
#11	-3.02% Nov 18, 2025 - Nov 24, 2025	-24.96% Mar 8, 2005 - Nov 2, 2005
#12	-1.52% Aug 29, 2025 - Sep 8, 2025	-20.97% Sep 4, 2003 - Jun 30, 2004
#13	-0.59% Aug 22, 2025 - Aug 26, 2025	-20.69% Dec 8, 2016 - Aug 28, 2017
#14	N/A	-17.93% Mar 4, 2026 - Apr 16, 2026
#15	N/A	-17.50% May 17, 2001 - Jun 27, 2001