StockComparison Logo
vs

MCRB vs SPY

Comparison between Seres Therapeutics Inc (MCRB, Company) and SPDR S&P 500 ETF Trust (SPY, ETF).

5-Year PerformanceSPY has outperformed MCRB, delivering a return of +12.8% compared to -48.2%

MCRB vs SPY - Performance Comparison

Key Characteristics

Financial metrics and valuation ratios

Market Cap / Net Assets
MCRB
$46M
Winner
SPY
$795B
Expense Ratio
MCRB
N/A
SPY
0.09%
Max Drawdown
MCRB
99.58%
Winner
SPY
56.47%
Sharpe Ratio
MCRB
-1.01
Winner
SPY
1.28
5Y Beta
MCRB
1.08
Winner
SPY
1.00
Industry
MCRB
Biotechnology
SPY
N/A
P/E Ratio
Winner
MCRB
-2.07
SPY
26.08
Forward P/E
Winner
MCRB
10.82
SPY
20.95
PEG Ratio
Winner
MCRB
-0.11
SPY
0.37
5Y Dividends CAGR
MCRB
N/A
SPY
6.00%
5Y EPS CAGR
MCRB
-39.84%
Winner
SPY
26.38%
Debt to Equity
Winner
MCRB
0.00%
SPY
45.86%
P/S Ratio
MCRB
24.22
Winner
SPY
3.75
P/B Ratio
Winner
MCRB
1.30
SPY
5.57

MCRB vs SPY - Historical Returns

Returns include dividend reinvestment.

1M
MCRB
-6.14%
Winner
SPY
+3.32%
3M
MCRB
-41.16%
Winner
SPY
+2.65%
6M
MCRB
-46.13%
Winner
SPY
+11.67%
1Y
MCRB
-75.77%
Winner
SPY
+20.15%
5Y(CAGR)
MCRB
-48.19%
Winner
SPY
+12.77%
10Y(CAGR)
MCRB
-31.97%
Winner
SPY
+15.20%
Max(CAGR)
MCRB
-38.33%
Winner
SPY
+8.55%

MCRB vs SPY - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

YearMCRBSPY
2026-69.24%+12.35%
2025-11.78%+18.00%
2024-40.64%+25.59%
2023-74.07%+26.72%
2022-36.65%-18.64%
2021-66.76%+30.52%
2020+631.34%+17.28%
2019-28.57%+31.09%
2018-57.16%-5.24%
2017+1.30%+20.78%
2016-70.97%+13.59%
2015-31.73%+1.31%
2014N/A+14.56%
2013N/A+29.00%
2012N/A+14.17%
2011N/A+0.85%
2010N/A+13.14%
2009N/A+22.67%
2008N/A-36.25%
2007N/A+5.32%
2006N/A+13.85%
2005N/A+5.32%
2004N/A+10.75%
2003N/A+24.18%
2002N/A-22.42%
2001N/A-10.13%
2000N/A-8.84%
1999N/A+8.61%

MCRB vs SPY Drawdown Comparison

The maximum drawdown for MCRB was -99.58%, occurring on Aug 18, 2026. This drawdown has not yet recovered.

The maximum drawdown for SPY was -55.20%, occurring on Mar 9, 2009. Recovery took 1224 trading sessions.

The current MCRB drawdown is -99.55%. The current SPY drawdown is -1.85%.

RankMCRBSPY
#1-99.58%
Jun 26, 2015 - Aug 18, 2026
-55.20%
Oct 9, 2007 - Aug 16, 2012
#2N/A-47.50%
Mar 24, 2000 - Oct 26, 2006
#3N/A-33.70%
Feb 19, 2020 - Aug 10, 2020
#4N/A-24.50%
Jan 3, 2022 - Dec 13, 2023
#5N/A-19.34%
Sep 20, 2018 - Apr 12, 2019
#6N/A-18.76%
Feb 19, 2025 - Jun 26, 2025
#7N/A-13.02%
Jul 20, 2015 - Apr 18, 2016
#8N/A-10.10%
Jan 26, 2018 - Aug 6, 2018
#9N/A-9.44%
Sep 2, 2020 - Nov 11, 2020
#10N/A-9.30%
Jan 19, 2000 - Mar 17, 2000
#11N/A-9.05%
Jul 19, 2007 - Oct 5, 2007
#12N/A-8.88%
Jan 27, 2026 - Apr 14, 2026
#13N/A-8.41%
Jul 16, 2024 - Sep 19, 2024
#14N/A-7.35%
Sep 14, 2012 - Jan 2, 2013
#15N/A-7.27%
Sep 18, 2014 - Oct 31, 2014

Correlation

Correlation between MCRB and SPY is -0.58 which considered as a moderate negative correlation - the stocks show some tendency to move in opposite directions.

-0.58
-101

Select Stocks to Compare

Popular: MCRB vs SPY