LRMR vs UPB

Comparison between Larimar Therapeutics Inc (LRMR, Company) and Upstream Bio Inc (UPB, Company).

Both LRMR and UPB are from the Healthcare sector.

LRMR vs UPB - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	LRMR(COMPANY)	UPB(COMPANY)
Market Cap	$357M	$359M
Max Drawdown	99.75%	81.29%
Sharpe Ratio	0.67	-0.16
5Y Beta	1.59	1.15
Industry	Biotechnology	Biotechnology
P/E Ratio	-1.72	-2.27
PEG Ratio	-0.05	N/A
5Y EPS CAGR	-8.46%	N/A
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-31.51%	-39.09%
P/S Ratio	N/A	102.88
P/B Ratio	2.27	1.12

Market Cap

LRMR

$357M

Winner

UPB

$359M

Max Drawdown

LRMR

99.75%

Winner

UPB

81.29%

Sharpe Ratio

Winner

LRMR

0.67

UPB

-0.16

5Y Beta

LRMR

1.59

Winner

UPB

1.15

Industry

LRMR

Biotechnology

UPB

Biotechnology

P/E Ratio

LRMR

-1.72

Winner

UPB

-2.27

PEG Ratio

LRMR

-0.05

UPB

N/A

5Y EPS CAGR

LRMR

-8.46%

UPB

N/A

Debt to Equity

LRMR

0.00%

UPB

0.00%

Free Cash Flow Yield

Winner

LRMR

-31.51%

UPB

-39.09%

P/S Ratio

LRMR

N/A

UPB

102.88

P/B Ratio

LRMR

2.27

Winner

UPB

1.12

LRMR vs UPB - Historical Returns

Returns include dividend reinvestment.

Period	LRMR	UPB
1 month	-15.98%	-31.84%
3 months	-27.25%	-35.35%
6 months	-14.32%	-77.52%
1 year	+19.24%	-47.23%
5 years(CAGR)	-16.06%	N/A
10 years(CAGR)	-26.29%	N/A
Max(CAGR)	-29.71%	-53.67%

Winner

LRMR

-15.98%

UPB

-31.84%

Winner

LRMR

-27.25%

UPB

-35.35%

Winner

LRMR

-14.32%

UPB

-77.52%

Winner

LRMR

+19.24%

UPB

-47.23%

5Y(CAGR)

LRMR

-16.06%

UPB

N/A

10Y(CAGR)

LRMR

-26.29%

UPB

N/A

Max(CAGR)

Winner

LRMR

-29.71%

UPB

-53.67%

LRMR vs UPB - Annual Returns (2014 - 2026)

Returns include dividend reinvestment.

Year	LRMR	UPB
2026	+0.00%	-77.47%
2025	-4.99%	+66.56%
2024	-24.27%	-25.27%
2023	+13.75%	N/A
2022	-61.58%	N/A
2021	-50.95%	N/A
2020	+60.74%	N/A
2019	-78.06%	N/A
2018	+3.34%	N/A
2017	+42.59%	N/A
2016	-50.23%	N/A
2015	-79.66%	N/A
2014	+56.15%	N/A

LRMR vs UPB Drawdown Comparison

The maximum drawdown for LRMR was -99.75%, occurring on Aug 5, 2022. This drawdown has not yet recovered.

The maximum drawdown for UPB was -81.29%, occurring on Jun 12, 2026. This drawdown has not yet recovered.

The current LRMR drawdown is -99.44%. The current UPB drawdown is -81.29%.

Rank	LRMR	UPB
#1	-99.75% Mar 19, 2015 - Aug 5, 2022	-81.29% Jan 13, 2026 - Jun 12, 2026
#2	-22.18% Sep 2, 2014 - Oct 30, 2014	-77.84% Nov 5, 2024 - Nov 25, 2025
#3	-16.93% Jan 8, 2015 - Jan 26, 2015	-14.99% Dec 22, 2025 - Jan 12, 2026
#4	-12.88% Jun 23, 2014 - Aug 28, 2014	-13.70% Dec 1, 2025 - Dec 16, 2025
#5	-12.79% Oct 30, 2014 - Nov 24, 2014	-6.45% Oct 21, 2024 - Nov 5, 2024
#6	-11.17% Jan 27, 2015 - Feb 23, 2015	-3.38% Dec 16, 2025 - Dec 18, 2025
#7	-10.00% Feb 23, 2015 - Mar 10, 2015	-2.88% Nov 25, 2025 - Dec 1, 2025
#8	-8.22% Nov 28, 2014 - Dec 17, 2014	-1.71% Dec 18, 2025 - Dec 22, 2025
#9	-3.27% Dec 26, 2014 - Jan 6, 2015	-1.63% Oct 14, 2024 - Oct 16, 2024
#10	-1.18% Mar 12, 2015 - Mar 16, 2015	-0.13% Oct 16, 2024 - Oct 18, 2024
#11	-0.99% Aug 28, 2014 - Sep 2, 2014	N/A