UPB vs PBYI
Comparison between Upstream Bio Inc (UPB, Company) and Puma Biotechnology Inc (PBYI, Company).
Both UPB and PBYI are from the Healthcare sector.
UPB vs PBYI - Performance Comparison
Key Characteristics
Financial metrics and valuation ratios
Market Cap
Winner
UPB
$359M
PBYI
$357M
Max Drawdown
Winner
UPB
81.29%
PBYI
99.40%
Sharpe Ratio
UPB
-0.16
Winner
PBYI
1.30
5Y Beta
UPB
1.15
Winner
PBYI
0.83
Industry
UPB
Biotechnology
PBYI
Biotechnology
P/E Ratio
Winner
UPB
-2.27
PBYI
14.45
Forward P/E
UPB
N/A
PBYI
3.46
PEG Ratio
UPB
N/A
PBYI
0.03
Debt to Equity
Winner
UPB
0.00%
PBYI
8.79%
Free Cash Flow Yield
UPB
-39.09%
Winner
PBYI
14.99%
P/S Ratio
UPB
102.88
Winner
PBYI
1.62
P/B Ratio
Winner
UPB
1.12
PBYI
2.78
UPB vs PBYI - Historical Returns
Returns include dividend reinvestment.
1M
UPB
-31.84%
Winner
PBYI
+3.53%
3M
UPB
-35.35%
Winner
PBYI
+24.66%
6M
UPB
-77.52%
Winner
PBYI
+25.09%
1Y
UPB
-47.23%
Winner
PBYI
+105.90%
5Y(CAGR)
UPB
N/A
PBYI
-8.37%
10Y(CAGR)
UPB
N/A
PBYI
-13.95%
Max(CAGR)
UPB
-53.67%
Winner
PBYI
-4.48%
UPB vs PBYI - Annual Returns (2012 - 2026)
Returns include dividend reinvestment.
| Year | UPB | PBYI |
|---|---|---|
| 2026 | -77.47% | +27.04% |
| 2025 | +66.56% | +90.71% |
| 2024 | -25.27% | -32.60% |
| 2023 | N/A | +4.84% |
| 2022 | N/A | +32.60% |
| 2021 | N/A | -70.57% |
| 2020 | N/A | +21.71% |
| 2019 | N/A | -59.64% |
| 2018 | N/A | -78.04% |
| 2017 | N/A | +213.81% |
| 2016 | N/A | -58.25% |
| 2015 | N/A | -58.71% |
| 2014 | N/A | +85.45% |
| 2013 | N/A | +444.61% |
| 2012 | N/A | +33.93% |
UPB vs PBYI Drawdown Comparison
The maximum drawdown for UPB was -81.29%, occurring on Jun 12, 2026. This drawdown has not yet recovered.
The maximum drawdown for PBYI was -99.40%, occurring on May 11, 2022. This drawdown has not yet recovered.
The current UPB drawdown is -81.29%. The current PBYI drawdown is -97.34%.
| Rank | UPB | PBYI |
|---|---|---|
| #1 | -81.29% Jan 13, 2026 - Jun 12, 2026 | -99.40% Sep 18, 2014 - May 11, 2022 |
| #2 | -77.84% Nov 5, 2024 - Nov 25, 2025 | -60.70% Jan 21, 2014 - Jul 23, 2014 |
| #3 | -14.99% Dec 22, 2025 - Jan 12, 2026 | -39.73% Sep 9, 2013 - Dec 5, 2013 |
| #4 | -13.70% Dec 1, 2025 - Dec 16, 2025 | -23.10% Jul 23, 2014 - Aug 18, 2014 |
| #5 | -6.45% Oct 21, 2024 - Nov 5, 2024 | -21.43% Apr 24, 2012 - Aug 20, 2012 |
| #6 | -3.38% Dec 16, 2025 - Dec 18, 2025 | -19.73% Oct 23, 2012 - Jan 15, 2013 |
| #7 | -2.88% Nov 25, 2025 - Dec 1, 2025 | -19.28% Apr 17, 2013 - May 16, 2013 |
| #8 | -1.71% Dec 18, 2025 - Dec 22, 2025 | -18.00% Jul 22, 2013 - Sep 9, 2013 |
| #9 | -1.63% Oct 14, 2024 - Oct 16, 2024 | -15.23% Jan 24, 2013 - Mar 6, 2013 |
| #10 | -0.13% Oct 16, 2024 - Oct 18, 2024 | -14.09% May 29, 2013 - Jun 19, 2013 |
| #11 | N/A | -10.14% Oct 8, 2012 - Oct 19, 2012 |
| #12 | N/A | -9.33% Aug 18, 2014 - Aug 26, 2014 |
| #13 | N/A | -8.78% Dec 9, 2013 - Dec 16, 2013 |
| #14 | N/A | -8.36% Mar 28, 2013 - Apr 15, 2013 |
| #15 | N/A | -7.30% Dec 24, 2013 - Jan 9, 2014 |
Correlation
Correlation between UPB and PBYI is 0.02 which considered as a very weak or no correlation - the stocks move independently of each other.
0.02
-101
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