KPTI vs OPOF

Comparison between Karyopharm Therapeutics Inc (KPTI, Company) and Old Point Financial Corp (OPOF, Company).

KPTI is from the Healthcare sector, while OPOF is from the Financial Services sector.

5-Year PerformanceOPOF has outperformed KPTI, delivering a return of +24.8% compared to -43.8%

KPTI vs OPOF - Performance Comparison

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Key Characteristics

Financial metrics and valuation ratios

Metric	KPTI(COMPANY)	OPOF(COMPANY)
Market Cap	$215M	$215M
Max Drawdown	99.50%	70.83%
Sharpe Ratio	1.17	2.52
5Y Beta	0.81	N/A
Industry	Biotechnology	Banks - Regional
P/E Ratio	-0.65	24.69
PEG Ratio	-0.01	1.16
5Y Dividends CAGR	N/A	3.13%
5Y EPS CAGR	-18.43%	2.23%
Debt to Equity	0.00%	56.01%
Free Cash Flow Yield	-27.51%	5.84%
P/S Ratio	1.50	2.51
P/B Ratio	12.05	1.82

Market Cap

KPTI

$215M

Winner

OPOF

$215M

Max Drawdown

KPTI

99.50%

Winner

OPOF

70.83%

Sharpe Ratio

KPTI

1.17

Winner

OPOF

2.52

5Y Beta

KPTI

0.81

OPOF

N/A

Industry

KPTI

Biotechnology

OPOF

Banks - Regional

P/E Ratio

Winner

KPTI

-0.65

OPOF

24.69

PEG Ratio

Winner

KPTI

-0.01

OPOF

1.16

5Y Dividends CAGR

KPTI

N/A

OPOF

3.13%

5Y EPS CAGR

KPTI

-18.43%

Winner

OPOF

2.23%

Debt to Equity

Winner

KPTI

0.00%

OPOF

56.01%

Free Cash Flow Yield

KPTI

-27.51%

Winner

OPOF

5.84%

P/S Ratio

Winner

KPTI

1.50

OPOF

2.51

P/B Ratio

KPTI

12.05

Winner

OPOF

1.82

KPTI vs OPOF - Historical Returns

Returns include dividend reinvestment.

Period	KPTI	OPOF
1 month	-12.61%	+5.59%
3 months	-14.23%	+7.29%
6 months	+24.45%	+38.30%
1 year	+95.65%	+128.76%
5 years(CAGR)	-43.81%	+24.78%
10 years(CAGR)	-22.98%	+13.00%
Max(CAGR)	-23.61%	+6.86%

KPTI

-12.61%

Winner

OPOF

+5.59%

KPTI

-14.23%

Winner

OPOF

+7.29%

KPTI

+24.45%

Winner

OPOF

+38.30%

KPTI

+95.65%

Winner

OPOF

+128.76%

5Y(CAGR)

KPTI

-43.81%

Winner

OPOF

+24.78%

10Y(CAGR)

KPTI

-22.98%

Winner

OPOF

+13.00%

Max(CAGR)

KPTI

-23.61%

Winner

OPOF

+6.86%

KPTI vs OPOF - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	KPTI	OPOF
2026	+9.39%	N/A
2025	-39.54%	+63.94%
2024	-24.96%	+45.44%
2023	-73.47%	-30.01%
2022	-52.11%	+18.08%
2021	-62.00%	+27.76%
2020	-17.31%	-29.19%
2019	+100.52%	+26.93%
2018	-5.54%	-25.33%
2017	-0.41%	+18.64%
2016	-30.16%	+37.87%
2015	-65.12%	+15.49%
2014	+62.67%	+19.03%
2013	+42.80%	+17.08%
2012	N/A	+12.68%
2011	N/A	-15.61%
2010	N/A	-24.59%
2009	N/A	-10.51%
2008	N/A	+0.81%
2007	N/A	-7.69%
2006	N/A	+0.37%
2005	N/A	-12.52%
2004	N/A	+21.63%
2003	N/A	+19.61%
2002	N/A	+33.84%
2001	N/A	+75.24%
2000	N/A	-10.73%
1999	N/A	-22.77%

KPTI vs OPOF Drawdown Comparison

The maximum drawdown for KPTI was -99.50%, occurring on Apr 1, 2025. This drawdown has not yet recovered.

The maximum drawdown for OPOF was -63.92%, occurring on Mar 18, 2020. Recovery took 1916 trading sessions.

The current KPTI drawdown is -98.89%.

Rank	KPTI	OPOF
#1	-99.50% Jun 13, 2014 - Apr 1, 2025	-63.92% Jul 3, 2017 - Feb 14, 2025
#2	-43.74% Mar 6, 2014 - Jun 13, 2014	-63.90% May 12, 2003 - Dec 2, 2016
#3	-10.42% Dec 20, 2013 - Jan 15, 2014	-38.61% Nov 1, 1999 - Jul 24, 2001
#4	-9.08% Jan 31, 2014 - Feb 12, 2014	-12.50% Sep 6, 2001 - Oct 2, 2001
#5	-8.83% Mar 4, 2014 - Mar 6, 2014	-9.06% Feb 21, 2003 - Mar 17, 2003
#6	-5.88% Jan 22, 2014 - Jan 30, 2014	-9.04% Jul 3, 2002 - Oct 16, 2002
#7	-4.87% Feb 27, 2014 - Mar 4, 2014	-8.50% May 16, 2017 - Jun 28, 2017
#8	-4.36% Feb 13, 2014 - Feb 20, 2014	-7.74% Oct 2, 2001 - Dec 12, 2001
#9	-3.39% Dec 9, 2013 - Dec 13, 2013	-7.41% Jan 2, 2003 - Jan 30, 2003
#10	-1.60% Nov 29, 2013 - Dec 6, 2013	-7.07% Nov 29, 2002 - Dec 31, 2002
#11	-1.48% Nov 8, 2013 - Nov 29, 2013	-6.60% May 13, 2002 - Jul 3, 2002
#12	-0.44% Nov 6, 2013 - Nov 8, 2013	-6.55% Dec 28, 2001 - Mar 26, 2002
#13	N/A	-6.36% Dec 7, 2016 - Dec 14, 2016
#14	N/A	-5.94% Mar 18, 2003 - Mar 25, 2003
#15	N/A	-5.79% Mar 28, 2003 - May 8, 2003

Correlation

Correlation between KPTI and OPOF is -0.52 which considered as a moderate negative correlation - the stocks show some tendency to move in opposite directions.

-0.52

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