ISRG vs VRTX

Comparison between Intuitive Surgical Inc (ISRG, Company) and Vertex Pharmaceuticals Inc (VRTX, Company).

Both ISRG and VRTX are from the Healthcare sector.

5-Year PerformanceVRTX has outperformed ISRG, delivering a return of +18.7% compared to +0.4%

ISRG vs VRTX - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	ISRG(COMPANY)	VRTX(COMPANY)
Market Cap	$121B	$120B
Max Drawdown	82.26%	91.77%
Sharpe Ratio	-1.15	0.09
5Y Beta	1.14	0.50
Industry	Medical Instruments & Supplies	Biotechnology
P/E Ratio	38.48	27.73
Forward P/E	33.67	24.94
PEG Ratio	1.80	1.63
5Y EPS CAGR	14.10%	9.89%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	3.07%	3.09%
P/S Ratio	11.06	9.82
P/B Ratio	6.78	6.32

Market Cap

Winner

ISRG

$121B

VRTX

$120B

Max Drawdown

Winner

ISRG

82.26%

VRTX

91.77%

Sharpe Ratio

ISRG

-1.15

Winner

VRTX

0.09

5Y Beta

ISRG

1.14

Winner

VRTX

0.50

Industry

ISRG

Medical Instruments & Supplies

VRTX

Biotechnology

P/E Ratio

ISRG

38.48

Winner

VRTX

27.73

Forward P/E

ISRG

33.67

Winner

VRTX

24.94

PEG Ratio

ISRG

1.80

Winner

VRTX

1.63

5Y EPS CAGR

Winner

ISRG

14.10%

VRTX

9.89%

Debt to Equity

ISRG

0.00%

VRTX

0.00%

Free Cash Flow Yield

ISRG

3.07%

Winner

VRTX

3.09%

P/S Ratio

ISRG

11.06

Winner

VRTX

9.82

P/B Ratio

ISRG

6.78

Winner

VRTX

6.32

ISRG vs VRTX - Historical Returns

Returns include dividend reinvestment.

Period	ISRG	VRTX
1 month	-17.65%	+1.00%
3 months	-30.66%	+8.73%
6 months	-36.64%	+1.00%
1 year	-33.85%	-0.81%
5 years(CAGR)	+0.40%	+18.73%
10 years(CAGR)	+15.79%	+17.55%
Max(CAGR)	+21.57%	+14.32%

ISRG

-17.65%

Winner

VRTX

+1.00%

ISRG

-30.66%

Winner

VRTX

+8.73%

ISRG

-36.64%

Winner

VRTX

+1.00%

ISRG

-33.85%

Winner

VRTX

-0.81%

5Y(CAGR)

ISRG

+0.40%

Winner

VRTX

+18.73%

10Y(CAGR)

ISRG

+15.79%

Winner

VRTX

+17.55%

Max(CAGR)

Winner

ISRG

+21.57%

VRTX

+14.32%

ISRG vs VRTX - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	ISRG	VRTX
2026	-40.92%	+4.64%
2025	+8.08%	+11.73%
2024	+57.70%	-2.00%
2023	+27.00%	+42.26%
2022	-26.29%	+29.77%
2021	+34.74%	-4.28%
2020	+36.98%	+7.70%
2019	+26.85%	+33.44%
2018	+27.63%	+8.37%
2017	+70.59%	+100.11%
2016	+15.85%	-40.05%
2015	+3.92%	+2.24%
2014	+39.19%	+60.91%
2013	-22.80%	+70.22%
2012	+3.96%	+30.00%
2011	+72.12%	-7.72%
2010	-16.52%	-20.82%
2009	+129.16%	+39.62%
2008	-60.80%	+31.23%
2007	+241.87%	-37.05%
2006	-17.19%	+34.12%
2005	+210.82%	+170.21%
2004	+136.25%	+0.67%
2003	+40.08%	-36.74%
2002	-36.82%	-35.41%
2001	+22.92%	-61.05%
2000	-6.80%	+281.33%
1999	N/A	+32.38%

ISRG vs VRTX Drawdown Comparison

The maximum drawdown for ISRG was -82.26%, occurring on Apr 11, 2001. Recovery took 1103 trading sessions.

The maximum drawdown for VRTX was -91.77%, occurring on Nov 11, 2003. Recovery took 3434 trading sessions.

The current ISRG drawdown is -45.61%. The current VRTX drawdown is -10.67%.

Rank	ISRG	VRTX
#1	-82.26% Jul 31, 2000 - Dec 21, 2004	-91.77% Nov 2, 2000 - Jul 2, 2014
#2	-75.89% Apr 10, 2008 - Mar 1, 2010	-55.25% Mar 6, 2000 - Jun 16, 2000
#3	-49.90% Nov 8, 2021 - Jan 18, 2024	-49.10% Aug 19, 2015 - Jul 19, 2017
#4	-45.61% Jan 22, 2025 - Jul 23, 2026	-41.60% Jul 20, 2020 - Aug 15, 2022
#5	-40.52% Feb 20, 2020 - Jul 17, 2020	-29.08% Sep 28, 2000 - Oct 25, 2000
#6	-40.11% May 1, 2012 - Mar 14, 2016	-29.07% Nov 8, 2024 - Jul 2, 2026
#7	-36.54% Jan 31, 2006 - May 30, 2007	-22.82% Jul 12, 2000 - Aug 16, 2000
#8	-36.21% Apr 15, 2010 - Jul 20, 2011	-21.18% Sep 28, 2018 - Jan 18, 2019
#9	-33.43% Dec 7, 2007 - Apr 10, 2008	-19.52% Jan 21, 2000 - Feb 7, 2000
#10	-24.33% Oct 1, 2018 - Mar 21, 2019	-19.39% Feb 11, 2020 - Apr 6, 2020
#11	-22.31% Jul 21, 2011 - Oct 19, 2011	-17.73% Mar 12, 2018 - Jul 12, 2018
#12	-21.78% Apr 10, 2019 - Nov 26, 2019	-17.36% Jul 24, 2017 - Jan 23, 2018
#13	-21.19% Apr 7, 2005 - Jul 11, 2005	-15.45% Jan 18, 2019 - Oct 29, 2019
#14	-19.12% Oct 25, 2007 - Dec 5, 2007	-15.26% Jan 22, 2015 - Mar 16, 2015
#15	-18.18% Jun 21, 2000 - Jul 10, 2000	-14.46% Jul 11, 2014 - Sep 19, 2014