IONS vs GKOS

Comparison between Ionis Pharmaceuticals Inc (IONS, Company) and Glaukos Corporation (GKOS, Company).

Both IONS and GKOS are from the Healthcare sector.

5-Year PerformanceGKOS has outperformed IONS, delivering a return of +25.8% compared to +9.0%

IONS vs GKOS - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	IONS(COMPANY)	GKOS(COMPANY)
Market Cap	$8.96B	$8.91B
Max Drawdown	91.72%	69.57%
Sharpe Ratio	0.73	1.08
5Y Beta	0.66	1.30
Industry	Biotechnology	Medical Devices
P/E Ratio	-51.26	-46.43
Forward P/E	90.91	2000.00
PEG Ratio	-1.08	-0.97
5Y EPS CAGR	-21.44%	12.32%
Debt to Equity	88.01%	0.00%
Free Cash Flow Yield	-10.84%	-0.21%
P/S Ratio	8.44	16.28
P/B Ratio	17.96	13.40

Market Cap

Winner

IONS

$8.96B

GKOS

$8.91B

Max Drawdown

IONS

91.72%

Winner

GKOS

69.57%

Sharpe Ratio

IONS

0.73

Winner

GKOS

1.08

5Y Beta

Winner

IONS

0.66

GKOS

1.30

Industry

IONS

Biotechnology

GKOS

Medical Devices

P/E Ratio

Winner

IONS

-51.26

GKOS

-46.43

Forward P/E

Winner

IONS

90.91

GKOS

2000.00

PEG Ratio

Winner

IONS

-1.08

GKOS

-0.97

5Y EPS CAGR

IONS

-21.44%

Winner

GKOS

12.32%

Debt to Equity

IONS

88.01%

Winner

GKOS

0.00%

Free Cash Flow Yield

IONS

-10.84%

Winner

GKOS

-0.21%

P/S Ratio

Winner

IONS

8.44

GKOS

16.28

P/B Ratio

IONS

17.96

Winner

GKOS

13.40

IONS vs GKOS - Historical Returns

Returns include dividend reinvestment.

Period	IONS	GKOS
1 month	-31.07%	+5.23%
3 months	-22.53%	+24.50%
6 months	-31.87%	+28.04%
1 year	+35.92%	+60.11%
5 years(CAGR)	+9.00%	+25.82%
10 years(CAGR)	+6.73%	+15.79%
Max(CAGR)	+6.36%	+15.34%

IONS

-31.07%

Winner

GKOS

+5.23%

IONS

-22.53%

Winner

GKOS

+24.50%

IONS

-31.87%

Winner

GKOS

+28.04%

IONS

+35.92%

Winner

GKOS

+60.11%

5Y(CAGR)

IONS

+9.00%

Winner

GKOS

+25.82%

10Y(CAGR)

IONS

+6.73%

Winner

GKOS

+15.79%

Max(CAGR)

IONS

+6.36%

Winner

GKOS

+15.34%

IONS vs GKOS - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	IONS	GKOS
2026	-29.76%	+37.27%
2025	+128.05%	-24.57%
2024	-33.88%	+94.53%
2023	+34.62%	+81.15%
2022	+15.86%	-7.89%
2021	-46.41%	-36.90%
2020	-7.14%	+38.27%
2019	+12.35%	+1.34%
2018	+9.77%	+107.42%
2017	+6.25%	-23.93%
2016	-22.45%	+43.82%
2015	+0.58%	-20.92%
2014	+54.85%	N/A
2013	+268.21%	N/A
2012	+44.00%	N/A
2011	-29.93%	N/A
2010	-10.20%	N/A
2009	-23.22%	N/A
2008	-7.80%	N/A
2007	+44.10%	N/A
2006	+111.81%	N/A
2005	-9.66%	N/A
2004	-13.36%	N/A
2003	-4.97%	N/A
2002	-68.69%	N/A
2001	+130.55%	N/A
2000	+77.49%	N/A
1999	-44.34%	N/A

IONS vs GKOS Drawdown Comparison

The maximum drawdown for IONS was -91.43%, occurring on Mar 18, 2003. Recovery took 3357 trading sessions.

The maximum drawdown for GKOS was -69.57%, occurring on Mar 20, 2020. Recovery took 366 trading sessions.

The current IONS drawdown is -35.31%. The current GKOS drawdown is -5.73%.

Rank	IONS	GKOS
#1	-91.43% Mar 6, 2000 - Jul 11, 2013	-69.57% Aug 1, 2019 - Jan 13, 2021
#2	-73.25% Mar 19, 2015 - Mar 14, 2019	-64.32% Apr 28, 2021 - Apr 8, 2024
#3	-70.39% Apr 8, 2019 - Feb 6, 2026	-55.00% Aug 18, 2015 - Jul 21, 2016
#4	-68.14% Dec 2, 1999 - Mar 1, 2000	-53.68% Jan 23, 2025 - Oct 24, 2025
#5	-61.05% Feb 21, 2014 - Dec 10, 2014	-53.09% Apr 3, 2017 - Aug 29, 2018
#6	-38.79% Feb 6, 2026 - Jul 20, 2026	-25.77% Aug 31, 2018 - Feb 12, 2019
#7	-28.35% Jul 12, 2013 - Sep 19, 2013	-22.03% Sep 27, 2016 - Jan 12, 2017
#8	-20.89% Sep 23, 2013 - Nov 27, 2013	-21.05% Mar 21, 2019 - Jul 31, 2019
#9	-19.78% Jan 12, 2015 - Mar 19, 2015	-17.93% Mar 1, 2021 - Apr 28, 2021
#10	-11.84% Dec 12, 2014 - Dec 19, 2014	-17.27% Jul 27, 2016 - Sep 14, 2016
#11	-11.49% Dec 19, 2014 - Jan 5, 2015	-11.05% Mar 2, 2017 - Mar 16, 2017
#12	-8.95% Jan 31, 2014 - Feb 13, 2014	-10.99% Feb 28, 2019 - Mar 19, 2019
#13	-8.58% Nov 11, 1999 - Nov 17, 1999	-10.31% Jun 25, 2015 - Jul 17, 2015
#14	-7.67% Jan 22, 2014 - Jan 31, 2014	-10.20% Aug 28, 2024 - Oct 29, 2024
#15	-7.49% Dec 23, 2013 - Jan 8, 2014	-9.60% Jul 16, 2024 - Aug 16, 2024