INSM vs MKSI

Comparison between Insmed Inc (INSM, Company) and MKS Instruments Inc (MKSI, Company).

INSM is from the Healthcare sector, while MKSI is from the Technology sector.

5-Year PerformanceINSM has outperformed MKSI, delivering a return of +33.1% compared to +16.8%

INSM vs MKSI - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	INSM(COMPANY)	MKSI(COMPANY)
Market Cap	$24B	$24B
Max Drawdown	98.65%	85.67%
Sharpe Ratio	0.31	2.31
5Y Beta	0.77	2.53
Industry	Biotechnology	Scientific & Technical Instruments
P/E Ratio	-19.78	72.74
Forward P/E	16.37	10.36
PEG Ratio	1.09	1.65
Dividend Yield	N/A	0.28%
5Y Dividends CAGR	N/A	2.77%
5Y EPS CAGR	12.24%	-7.80%
Debt to Equity	76.93%	144.01%
Free Cash Flow Yield	-3.88%	1.69%
P/S Ratio	28.42	5.94
P/B Ratio	33.77	8.46

Market Cap

INSM

$24B

Winner

MKSI

$24B

Max Drawdown

INSM

98.65%

Winner

MKSI

85.67%

Sharpe Ratio

INSM

0.31

Winner

MKSI

2.31

5Y Beta

Winner

INSM

0.77

MKSI

2.53

Industry

INSM

Biotechnology

MKSI

Scientific & Technical Instruments

P/E Ratio

Winner

INSM

-19.78

MKSI

72.74

Forward P/E

INSM

16.37

Winner

MKSI

10.36

PEG Ratio

Winner

INSM

1.09

MKSI

1.65

Dividend Yield

INSM

N/A

MKSI

0.28%

5Y Dividends CAGR

INSM

N/A

MKSI

2.77%

5Y EPS CAGR

Winner

INSM

12.24%

MKSI

-7.80%

Debt to Equity

Winner

INSM

76.93%

MKSI

144.01%

Free Cash Flow Yield

INSM

-3.88%

Winner

MKSI

1.69%

P/S Ratio

INSM

28.42

Winner

MKSI

5.94

P/B Ratio

INSM

33.77

Winner

MKSI

8.46

INSM vs MKSI - Historical Returns

Returns include dividend reinvestment.

Period	INSM	MKSI
1 month	+10.16%	-17.86%
3 months	-22.95%	+26.27%
6 months	-30.51%	+56.77%
1 year	+5.68%	+236.04%
5 years(CAGR)	+33.09%	+16.76%
10 years(CAGR)	+25.54%	+23.21%
Max(CAGR)	-1.58%	+11.46%

Winner

INSM

+10.16%

MKSI

-17.86%

INSM

-22.95%

Winner

MKSI

+26.27%

INSM

-30.51%

Winner

MKSI

+56.77%

INSM

+5.68%

Winner

MKSI

+236.04%

5Y(CAGR)

Winner

INSM

+33.09%

MKSI

+16.76%

10Y(CAGR)

Winner

INSM

+25.54%

MKSI

+23.21%

Max(CAGR)

INSM

-1.58%

Winner

MKSI

+11.46%

INSM vs MKSI - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	INSM	MKSI
2026	-38.67%	+105.53%
2025	+148.81%	+51.97%
2024	+130.59%	+5.36%
2023	+61.57%	+22.68%
2022	-28.97%	-51.89%
2021	-18.49%	+16.54%
2020	+40.70%	+35.47%
2019	+70.94%	+68.00%
2018	-59.58%	-33.59%
2017	+138.38%	+59.27%
2016	-23.26%	+69.39%
2015	+13.72%	+1.11%
2014	-9.74%	+25.09%
2013	+144.25%	+13.89%
2012	+112.38%	-6.11%
2011	-52.34%	+13.53%
2010	-18.08%	+37.41%
2009	+57.14%	+14.17%
2008	-43.67%	-20.65%
2007	-8.33%	-15.31%
2006	-58.69%	+21.73%
2005	-14.35%	-1.87%
2004	-27.43%	-35.77%
2003	+518.75%	+71.90%
2002	-88.60%	-39.84%
2001	+1.87%	+70.97%
2000	-78.95%	-53.91%
1999	N/A	+55.60%

INSM vs MKSI Drawdown Comparison

The maximum drawdown for INSM was -98.65%, occurring on Nov 25, 2011. Recovery took 6341 trading sessions.

The maximum drawdown for MKSI was -85.67%, occurring on Oct 9, 2002. Recovery took 4198 trading sessions.

The current INSM drawdown is -48.62%. The current MKSI drawdown is -22.34%.

Rank	INSM	MKSI
#1	-98.65% Aug 30, 2000 - Nov 17, 2025	-85.67% Mar 10, 2000 - Nov 15, 2016
#2	-56.54% Dec 1, 2025 - Jun 10, 2026	-69.20% Apr 5, 2021 - Jan 13, 2026
#3	-35.29% Jun 5, 2000 - Aug 3, 2000	-54.26% Mar 21, 2018 - Jul 23, 2020
#4	-28.69% Aug 3, 2000 - Aug 28, 2000	-27.10% Jun 30, 2026 - Jul 20, 2026
#5	-2.91% Jun 1, 2000 - Jun 5, 2000	-24.72% Jan 21, 2000 - Feb 8, 2000
#6	-2.36% Nov 19, 2025 - Nov 24, 2025	-23.04% Jun 8, 2017 - Sep 18, 2017
#7	-2.16% Nov 25, 2025 - Dec 1, 2025	-21.42% Jan 20, 2021 - Apr 1, 2021
#8	N/A	-20.06% Feb 17, 2026 - Apr 9, 2026
#9	N/A	-19.47% Aug 4, 2020 - Nov 11, 2020
#10	N/A	-17.48% Oct 31, 2017 - Feb 1, 2018
#11	N/A	-14.61% Feb 9, 2000 - Feb 24, 2000
#12	N/A	-14.20% Dec 31, 1999 - Jan 19, 2000
#13	N/A	-12.39% Nov 11, 1999 - Dec 7, 1999
#14	N/A	-11.04% Feb 1, 2018 - Feb 15, 2018
#15	N/A	-10.00% Jun 3, 2026 - Jun 11, 2026