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IDNA vs SPY

Comparison between ISHARES GENOMICS IMMUNOLOGY AND HEALTHCARE ETF (IDNA, ETF) and SPDR S&P 500 ETF Trust (SPY, ETF).

5-Year PerformanceSPY has outperformed IDNA, delivering a return of +13.3% compared to -8.2%

IDNA vs SPY - Performance Comparison

Key Characteristics

Financial metrics and valuation ratios

Net Assets
IDNA
$161M
Winner
SPY
$735B
Expense Ratio
IDNA
0.47%
Winner
SPY
0.09%
Max Drawdown
IDNA
68.69%
Winner
SPY
56.47%
Sharpe Ratio
IDNA
1.38
Winner
SPY
1.62
5Y Beta
Winner
IDNA
0.87
SPY
1.00
P/E Ratio
Winner
IDNA
-15.45
SPY
28.99
Forward P/E
IDNA
N/A
SPY
22.37
5Y Dividends CAGR
IDNA
3.10%
Winner
SPY
5.43%
5Y EPS CAGR
IDNA
N/A
SPY
26.05%
Debt to Equity
Winner
IDNA
10.39%
SPY
32.40%
P/S Ratio
IDNA
7.94
Winner
SPY
3.74
P/B Ratio
Winner
IDNA
3.37
SPY
5.61

IDNA vs SPY - Holdings Comparison

IDNA and SPY have 6 common holdings. Overlap is 0.42%

IDNA's top 25 holdings weight is 85.74%. SPY's top 25 holdings weight is 52.37%.

RankIDNASPY
#1
REVOLUTION MEDICINES INC ORDINARY SHARES (RVMD) - 7.00%
NVIDIA CORP (NVDA) - 8.10%
#2
MODERNA INC (MRNA) - 6.44%
APPLE INC (AAPL) - 7.02%
#3
IPSEN SA (n/a) - 5.17%
MICROSOFT CORP (MSFT) - 4.79%
#4
TAKEDA PHARMACEUTICAL CO LTD (n/a) - 4.43%
AMAZON.COM INC (AMZN) - 4.02%
#5
MERCK & CO INC (MRK) - 4.27%
ALPHABET INC CLASS A (GOOGL) - 3.51%
#6
BAYER AG (n/a) - 4.25%
BROADCOM INC (AVGO) - 3.10%
#7
GSK PLC (n/a) - 4.03%
ALPHABET INC CLASS C (GOOG) - 2.79%
#8
ROCHE HOLDING AG ORDINARY SHARES NEW (n/a) - 3.94%
META PLATFORMS INC CLASS A (META) - 2.08%
#9
BIONTECH SE ADR (BNTX) - 3.89%
TESLA INC (TSLA) - 1.89%
#10
EXELIXIS INC (EXEL) - 3.75%
MICRON TECHNOLOGY INC (MU) - 1.56%
#11
REGENERON PHARMACEUTICALS INC (REGN) - 3.72%
BERKSHIRE HATHAWAY INC CLASS B (BRK-B) - 1.37%
#12
TWIST BIOSCIENCE CORP (TWST) - 3.62%
ELI LILLY AND CO (LLY) - 1.31%
#13
INCYTE CORP (INCY) - 3.57%
JPMORGAN CHASE & CO (JPM) - 1.28%
#14
VERTEX PHARMACEUTICALS INC (VRTX) - 3.56%
ADVANCED MICRO DEVICES INC (AMD) - 1.27%
#15
SANOFI SA (n/a) - 3.28%
EXXON MOBIL CORP (XOM) - 0.97%
#16
GENMAB AS (n/a) - 3.18%
INTEL CORP (INTC) - 0.90%
#17
IMMUNITYBIO INC ORDINARY SHARES (IBRX) - 2.72%
JOHNSON & JOHNSON (JNJ) - 0.86%
#18
IDEAYA BIOSCIENCES INC (IDYA) - 2.68%
VISA INC CLASS A (V) - 0.85%
#19
CARIS LIFE SCIENCES INC (CAI) - 2.38%
WALMART INC (WMT) - 0.81%
#20
ARCUS BIOSCIENCES INC (RCUS) - 2.16%
CISCO SYSTEMS INC (CSCO) - 0.72%
#21
ONO PHARMACEUTICAL CO LTD (n/a) - 1.95%
COSTCO WHOLESALE CORP (COST) - 0.69%
#22
CRISPR THERAPEUTICS AG (CRSP) - 1.84%
CATERPILLAR INC (CAT) - 0.66%
#23
IOVANCE BIOTHERAPEUTICS INC (IOVA) - 1.42%
MASTERCARD INC CLASS A (MA) - 0.62%
#24
NOVAVAX INC (NVAX) - 1.32%
LAM RESEARCH CORP (LRCX) - 0.62%
#25
n/a (NUVB) - 1.17%
ABBVIE INC (ABBV) - 0.58%
Total Holdings76505

IDNA vs SPY - Historical Returns

Returns include dividend reinvestment.

1M
IDNA
-1.29%
Winner
SPY
+1.90%
3M
IDNA
-1.69%
Winner
SPY
+8.55%
6M
Winner
IDNA
+8.77%
SPY
+8.18%
1Y
Winner
IDNA
+42.30%
SPY
+25.79%
5Y(CAGR)
IDNA
-8.25%
Winner
SPY
+13.32%
10Y(CAGR)
IDNA
N/A
SPY
+15.19%
Max(CAGR)
IDNA
+3.09%
Winner
SPY
+8.47%

IDNA vs SPY - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

YearIDNASPY
2026+11.14%+8.26%
2025+16.60%+18.00%
2024-2.34%+25.59%
2023-7.24%+26.72%
2022-42.36%-18.64%
2021-4.55%+30.52%
2020+55.62%+17.28%
2019+20.82%+31.09%
2018N/A-5.24%
2017N/A+20.78%
2016N/A+13.59%
2015N/A+1.31%
2014N/A+14.56%
2013N/A+29.00%
2012N/A+14.17%
2011N/A+0.85%
2010N/A+13.14%
2009N/A+22.67%
2008N/A-36.25%
2007N/A+5.32%
2006N/A+13.85%
2005N/A+5.32%
2004N/A+10.75%
2003N/A+24.18%
2002N/A-22.42%
2001N/A-10.13%
2000N/A-8.84%
1999N/A+8.61%

IDNA vs SPY Drawdown Comparison

The maximum drawdown for IDNA was -68.26%, occurring on Oct 27, 2023. This drawdown has not yet recovered.

The maximum drawdown for SPY was -55.20%, occurring on Mar 9, 2009. Recovery took 1224 trading sessions.

The current IDNA drawdown is -45.12%. The current SPY drawdown is -2.90%.

RankIDNASPY
#1-68.26%
Sep 2, 2021 - Oct 27, 2023		-55.20%
Oct 9, 2007 - Aug 16, 2012
#2-26.93%
Mar 4, 2020 - Apr 17, 2020		-47.50%
Mar 24, 2000 - Oct 26, 2006
#3-22.23%
Feb 8, 2021 - Aug 9, 2021		-33.70%
Feb 19, 2020 - Aug 10, 2020
#4-14.38%
Jul 18, 2019 - Nov 20, 2019		-24.50%
Jan 3, 2022 - Dec 13, 2023
#5-13.58%
Jul 20, 2020 - Oct 9, 2020		-19.34%
Sep 20, 2018 - Apr 12, 2019
#6-9.93%
Oct 13, 2020 - Nov 27, 2020		-18.76%
Feb 19, 2025 - Jun 26, 2025
#7-9.34%
Dec 24, 2019 - Mar 4, 2020		-13.02%
Jul 20, 2015 - Apr 18, 2016
#8-8.30%
Dec 22, 2020 - Jan 14, 2021		-10.10%
Jan 26, 2018 - Aug 6, 2018
#9-7.52%
Aug 9, 2021 - Sep 2, 2021		-9.44%
Sep 2, 2020 - Nov 11, 2020
#10-7.36%
May 18, 2020 - Jun 22, 2020		-9.30%
Jan 19, 2000 - Mar 17, 2000
#11-6.03%
Apr 27, 2020 - May 7, 2020		-9.05%
Jul 19, 2007 - Oct 5, 2007
#12-4.87%
Jan 19, 2021 - Feb 2, 2021		-8.88%
Jan 27, 2026 - Apr 14, 2026
#13-4.19%
May 11, 2020 - May 18, 2020		-8.41%
Jul 16, 2024 - Sep 19, 2024
#14-3.85%
Jun 19, 2019 - Jun 28, 2019		-7.35%
Sep 14, 2012 - Jan 2, 2013
#15-3.70%
Jun 23, 2020 - Jul 8, 2020		-7.27%
Sep 18, 2014 - Oct 31, 2014

Correlation

Correlation between IDNA and SPY is -0.28 which considered as a very weak or no correlation - the stocks move independently of each other.

-0.28
-101

Dividend Comparison (1999 - 2026)

IDNA vs SPY dividend yield comparison.

YearIDNASPY
20260.00%0.24%
20251.18%1.07%
20240.98%1.21%
20231.04%1.40%
20220.54%1.65%
20210.70%1.20%
20200.26%1.52%
20190.80%1.75%
20180.00%2.04%
20170.00%1.80%
20160.00%2.03%
20150.00%2.06%
20140.00%1.87%
20130.00%1.81%
20120.00%2.18%
20110.00%2.05%
20100.00%1.80%
20090.00%1.95%
20080.00%3.02%
20070.00%1.85%
20060.00%1.73%
20050.00%1.73%
20040.00%1.82%
20030.00%1.47%
20020.00%1.70%
20010.00%1.25%
20000.00%1.15%
19990.00%0.24%

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