HOWL vs CTSO

Comparison between Werewolf Therapeutics Inc (HOWL, Company) and Cytosorbents Corp (CTSO, Company).

Both HOWL and CTSO are from the Healthcare sector.

5-Year PerformanceCTSO has outperformed HOWL, delivering a return of -45.9% compared to -51.8%

HOWL vs CTSO - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	HOWL(COMPANY)	CTSO(COMPANY)
Market Cap	$22M	$22M
Max Drawdown	98.48%	97.64%
Sharpe Ratio	-0.60	-0.88
5Y Beta	2.05	0.67
Industry	Biotechnology	Medical Devices
P/E Ratio	-0.39	-1.88
Forward P/E	N/A	7.20
5Y EPS CAGR	N/A	-2.06%
Debt to Equity	262.95%	772.97%
Free Cash Flow Yield	N/A	-46.14%

Market Cap

Winner

HOWL

$22M

CTSO

$22M

Max Drawdown

HOWL

98.48%

Winner

CTSO

97.64%

Sharpe Ratio

Winner

HOWL

-0.60

CTSO

-0.88

5Y Beta

HOWL

2.05

Winner

CTSO

0.67

Industry

HOWL

Biotechnology

CTSO

Medical Devices

P/E Ratio

HOWL

-0.39

Winner

CTSO

-1.88

Forward P/E

HOWL

N/A

CTSO

7.20

5Y EPS CAGR

HOWL

N/A

CTSO

-2.06%

Debt to Equity

Winner

HOWL

262.95%

CTSO

772.97%

Free Cash Flow Yield

HOWL

N/A

CTSO

-46.14%

HOWL vs CTSO - Historical Returns

Returns include dividend reinvestment.

Period	HOWL	CTSO
1 month	+49.35%	-7.26%
3 months	-32.35%	-44.31%
6 months	-36.52%	-46.30%
1 year	-64.62%	-61.10%
5 years(CAGR)	-51.80%	-45.88%
10 years(CAGR)	N/A	-23.11%
Max(CAGR)	-49.22%	-15.07%

Winner

HOWL

+49.35%

CTSO

-7.26%

Winner

HOWL

-32.35%

CTSO

-44.31%

Winner

HOWL

-36.52%

CTSO

-46.30%

HOWL

-64.62%

Winner

CTSO

-61.10%

5Y(CAGR)

HOWL

-51.80%

Winner

CTSO

-45.88%

10Y(CAGR)

HOWL

N/A

CTSO

-23.11%

Max(CAGR)

HOWL

-49.22%

Winner

CTSO

-15.07%

HOWL vs CTSO - Annual Returns (2013 - 2026)

Returns include dividend reinvestment.

Year	HOWL	CTSO
2026	-28.66%	-46.02%
2025	-59.39%	-30.52%
2024	-68.10%	-14.95%
2023	+88.29%	-39.01%
2022	-83.22%	-63.36%
2021	-26.02%	-49.94%
2020	N/A	+99.25%
2019	N/A	-50.96%
2018	N/A	+23.36%
2017	N/A	+15.04%
2016	N/A	-4.05%
2015	N/A	-49.36%
2014	N/A	+213.39%
2013	N/A	-3.85%

HOWL vs CTSO Drawdown Comparison

The maximum drawdown for HOWL was -98.48%, occurring on Jun 29, 2026. This drawdown has not yet recovered.

The maximum drawdown for CTSO was -97.64%, occurring on Jul 29, 2026. This drawdown has not yet recovered.

The current HOWL drawdown is -97.74%. The current CTSO drawdown is -97.64%.

Rank	HOWL	CTSO
#1	-98.48% Jul 2, 2021 - Jun 29, 2026	-97.64% Mar 23, 2015 - Jul 29, 2026
#2	-28.66% May 3, 2021 - Jun 30, 2021	-40.63% Feb 27, 2014 - Dec 22, 2014
#3	N/A	-40.00% Jan 8, 2013 - Jan 16, 2014
#4	N/A	-29.93% Jan 5, 2015 - Feb 25, 2015
#5	N/A	-20.65% Jan 22, 2014 - Feb 27, 2014
#6	N/A	-10.01% Dec 26, 2014 - Jan 2, 2015
#7	N/A	-9.40% Feb 25, 2015 - Mar 16, 2015
#8	N/A	-7.69% Jan 2, 2013 - Jan 4, 2013