GKOS vs IONS

Comparison between Glaukos Corporation (GKOS, Company) and Ionis Pharmaceuticals Inc (IONS, Company).

Both GKOS and IONS are from the Healthcare sector.

5-Year PerformanceGKOS has outperformed IONS, delivering a return of +25.8% compared to +9.0%

GKOS vs IONS - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	GKOS(COMPANY)	IONS(COMPANY)
Market Cap	$8.91B	$8.96B
Max Drawdown	69.57%	91.72%
Sharpe Ratio	1.08	0.73
5Y Beta	1.30	0.66
Industry	Medical Devices	Biotechnology
P/E Ratio	-46.43	-51.26
Forward P/E	2000.00	90.91
PEG Ratio	-0.97	-1.08
5Y EPS CAGR	12.32%	-21.44%
Debt to Equity	0.00%	88.01%
Free Cash Flow Yield	-0.21%	-10.84%
P/S Ratio	16.28	8.44
P/B Ratio	13.40	17.96

Market Cap

GKOS

$8.91B

Winner

IONS

$8.96B

Max Drawdown

Winner

GKOS

69.57%

IONS

91.72%

Sharpe Ratio

Winner

GKOS

1.08

IONS

0.73

5Y Beta

GKOS

1.30

Winner

IONS

0.66

Industry

GKOS

Medical Devices

IONS

Biotechnology

P/E Ratio

GKOS

-46.43

Winner

IONS

-51.26

Forward P/E

GKOS

2000.00

Winner

IONS

90.91

PEG Ratio

GKOS

-0.97

Winner

IONS

-1.08

5Y EPS CAGR

Winner

GKOS

12.32%

IONS

-21.44%

Debt to Equity

Winner

GKOS

0.00%

IONS

88.01%

Free Cash Flow Yield

Winner

GKOS

-0.21%

IONS

-10.84%

P/S Ratio

GKOS

16.28

Winner

IONS

8.44

P/B Ratio

Winner

GKOS

13.40

IONS

17.96

GKOS vs IONS - Historical Returns

Returns include dividend reinvestment.

Period	GKOS	IONS
1 month	+5.23%	-31.07%
3 months	+24.50%	-22.53%
6 months	+28.04%	-31.87%
1 year	+60.11%	+35.92%
5 years(CAGR)	+25.82%	+9.00%
10 years(CAGR)	+15.79%	+6.73%
Max(CAGR)	+15.34%	+6.36%

Winner

GKOS

+5.23%

IONS

-31.07%

Winner

GKOS

+24.50%

IONS

-22.53%

Winner

GKOS

+28.04%

IONS

-31.87%

Winner

GKOS

+60.11%

IONS

+35.92%

5Y(CAGR)

Winner

GKOS

+25.82%

IONS

+9.00%

10Y(CAGR)

Winner

GKOS

+15.79%

IONS

+6.73%

Max(CAGR)

Winner

GKOS

+15.34%

IONS

+6.36%

GKOS vs IONS - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	GKOS	IONS
2026	+37.27%	-29.76%
2025	-24.57%	+128.05%
2024	+94.53%	-33.88%
2023	+81.15%	+34.62%
2022	-7.89%	+15.86%
2021	-36.90%	-46.41%
2020	+38.27%	-7.14%
2019	+1.34%	+12.35%
2018	+107.42%	+9.77%
2017	-23.93%	+6.25%
2016	+43.82%	-22.45%
2015	-20.92%	+0.58%
2014	N/A	+54.85%
2013	N/A	+268.21%
2012	N/A	+44.00%
2011	N/A	-29.93%
2010	N/A	-10.20%
2009	N/A	-23.22%
2008	N/A	-7.80%
2007	N/A	+44.10%
2006	N/A	+111.81%
2005	N/A	-9.66%
2004	N/A	-13.36%
2003	N/A	-4.97%
2002	N/A	-68.69%
2001	N/A	+130.55%
2000	N/A	+77.49%
1999	N/A	-44.34%

GKOS vs IONS Drawdown Comparison

The maximum drawdown for GKOS was -69.57%, occurring on Mar 20, 2020. Recovery took 366 trading sessions.

The maximum drawdown for IONS was -91.43%, occurring on Mar 18, 2003. Recovery took 3357 trading sessions.

The current GKOS drawdown is -5.73%. The current IONS drawdown is -35.31%.

Rank	GKOS	IONS
#1	-69.57% Aug 1, 2019 - Jan 13, 2021	-91.43% Mar 6, 2000 - Jul 11, 2013
#2	-64.32% Apr 28, 2021 - Apr 8, 2024	-73.25% Mar 19, 2015 - Mar 14, 2019
#3	-55.00% Aug 18, 2015 - Jul 21, 2016	-70.39% Apr 8, 2019 - Feb 6, 2026
#4	-53.68% Jan 23, 2025 - Oct 24, 2025	-68.14% Dec 2, 1999 - Mar 1, 2000
#5	-53.09% Apr 3, 2017 - Aug 29, 2018	-61.05% Feb 21, 2014 - Dec 10, 2014
#6	-25.77% Aug 31, 2018 - Feb 12, 2019	-38.79% Feb 6, 2026 - Jul 20, 2026
#7	-22.03% Sep 27, 2016 - Jan 12, 2017	-28.35% Jul 12, 2013 - Sep 19, 2013
#8	-21.05% Mar 21, 2019 - Jul 31, 2019	-20.89% Sep 23, 2013 - Nov 27, 2013
#9	-17.93% Mar 1, 2021 - Apr 28, 2021	-19.78% Jan 12, 2015 - Mar 19, 2015
#10	-17.27% Jul 27, 2016 - Sep 14, 2016	-11.84% Dec 12, 2014 - Dec 19, 2014
#11	-11.05% Mar 2, 2017 - Mar 16, 2017	-11.49% Dec 19, 2014 - Jan 5, 2015
#12	-10.99% Feb 28, 2019 - Mar 19, 2019	-8.95% Jan 31, 2014 - Feb 13, 2014
#13	-10.31% Jun 25, 2015 - Jul 17, 2015	-8.58% Nov 11, 1999 - Nov 17, 1999
#14	-10.20% Aug 28, 2024 - Oct 29, 2024	-7.67% Jan 22, 2014 - Jan 31, 2014
#15	-9.60% Jul 16, 2024 - Aug 16, 2024	-7.49% Dec 23, 2013 - Jan 8, 2014