FOLD vs SPY

Comparison between Amicus Therapeutics Inc (FOLD, Company) and SPDR S&P 500 ETF Trust (SPY, ETF).

5-Year PerformanceSPY has outperformed FOLD, delivering a return of +13.9% compared to +7.5%

FOLD vs SPY - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	FOLD(COMPANY)	SPY(ETF)
Market Cap / Net Assets	$4.50B	$735B
Expense Ratio	N/A	0.09%
Max Drawdown	89.91%	56.47%
Sharpe Ratio	1.67	1.67
5Y Beta	N/A	1.00
Industry	Biotechnology	N/A
P/E Ratio	-164.36	28.81
Forward P/E	30.49	22.07
5Y Dividends CAGR	N/A	5.43%
5Y EPS CAGR	-39.28%	25.84%
Debt to Equity	143.18%	34.16%
Free Cash Flow Yield	0.66%	N/A
P/S Ratio	N/A	3.69
P/B Ratio	N/A	5.54

Market Cap / Net Assets

FOLD

$4.50B

Winner

SPY

$735B

Expense Ratio

FOLD

N/A

SPY

0.09%

Max Drawdown

FOLD

89.91%

Winner

SPY

56.47%

Sharpe Ratio

Winner

FOLD

1.67

SPY

1.67

5Y Beta

FOLD

N/A

SPY

1.00

Industry

FOLD

Biotechnology

SPY

N/A

P/E Ratio

Winner

FOLD

-164.36

SPY

28.81

Forward P/E

FOLD

30.49

Winner

SPY

22.07

5Y Dividends CAGR

FOLD

N/A

SPY

5.43%

5Y EPS CAGR

FOLD

-39.28%

Winner

SPY

25.84%

Debt to Equity

FOLD

143.18%

Winner

SPY

34.16%

Free Cash Flow Yield

FOLD

0.66%

SPY

N/A

P/S Ratio

FOLD

N/A

SPY

3.69

P/B Ratio

FOLD

N/A

SPY

5.54

FOLD vs SPY - Historical Returns

Returns include dividend reinvestment.

Period	FOLD	SPY
1 month	+0.56%	+5.49%
3 months	+1.40%	+8.03%
6 months	+63.18%	+13.34%
1 year	+96.08%	+28.89%
5 years(CAGR)	+7.51%	+13.90%
10 years(CAGR)	+6.42%	+15.59%
Max(CAGR)	+0.02%	+8.51%

FOLD

+0.56%

Winner

SPY

+5.49%

FOLD

+1.40%

Winner

SPY

+8.03%

Winner

FOLD

+63.18%

SPY

+13.34%

Winner

FOLD

+96.08%

SPY

+28.89%

5Y(CAGR)

FOLD

+7.51%

Winner

SPY

+13.90%

10Y(CAGR)

FOLD

+6.42%

Winner

SPY

+15.59%

Max(CAGR)

FOLD

+0.02%

Winner

SPY

+8.51%

FOLD vs SPY - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	FOLD	SPY
2026	+1.54%	+9.02%
2025	+52.95%	+18.00%
2024	-33.85%	+25.59%
2023	+18.94%	+26.72%
2022	+0.83%	-18.64%
2021	-46.97%	+30.52%
2020	+141.78%	+17.28%
2019	-2.99%	+31.09%
2018	-36.81%	-5.24%
2017	+180.51%	+20.78%
2016	-44.96%	+13.59%
2015	+12.66%	+1.31%
2014	+245.23%	+14.56%
2013	-17.25%	+29.00%
2012	-24.93%	+14.17%
2011	-24.56%	+0.85%
2010	+22.40%	+13.14%
2009	-50.37%	+22.67%
2008	-22.82%	-36.25%
2007	-25.50%	+5.32%
2006	N/A	+13.85%
2005	N/A	+5.32%
2004	N/A	+10.75%
2003	N/A	+24.18%
2002	N/A	-22.42%
2001	N/A	-10.13%
2000	N/A	-8.84%
1999	N/A	+8.61%

FOLD vs SPY Drawdown Comparison

The maximum drawdown for FOLD was -89.91%, occurring on Apr 16, 2014. Recovery took 1970 trading sessions.

The maximum drawdown for SPY was -55.20%, occurring on Mar 9, 2009. Recovery took 1224 trading sessions.

The current FOLD drawdown is -41.78%. The current SPY drawdown is -0.73%.

Rank	FOLD	SPY
#1	-89.91% Oct 8, 2007 - Aug 5, 2015	-55.20% Oct 9, 2007 - Aug 16, 2012
#2	-77.34% Dec 22, 2020 - Jun 20, 2025	-47.50% Mar 24, 2000 - Oct 26, 2006
#3	-75.15% Sep 14, 2015 - Oct 23, 2020	-33.70% Feb 19, 2020 - Aug 10, 2020
#4	-26.68% May 31, 2007 - Sep 19, 2007	-24.50% Jan 3, 2022 - Dec 13, 2023
#5	-26.28% Aug 5, 2015 - Sep 14, 2015	-19.34% Sep 20, 2018 - Apr 12, 2019
#6	-6.29% Oct 27, 2020 - Nov 3, 2020	-18.76% Feb 19, 2025 - Jun 26, 2025
#7	-5.85% Nov 27, 2020 - Dec 14, 2020	-13.02% Jul 20, 2015 - Apr 18, 2016
#8	-4.23% Nov 17, 2020 - Nov 25, 2020	-10.10% Jan 26, 2018 - Aug 6, 2018
#9	-4.08% Nov 5, 2020 - Nov 10, 2020	-9.44% Sep 2, 2020 - Nov 11, 2020
#10	-3.75% Oct 1, 2007 - Oct 5, 2007	-9.30% Jan 19, 2000 - Mar 17, 2000
#11	-2.24% Nov 10, 2020 - Nov 16, 2020	-9.05% Jul 19, 2007 - Oct 5, 2007
#12	-1.70% Sep 20, 2007 - Sep 27, 2007	-8.88% Jan 27, 2026 - Apr 14, 2026
#13	-0.13% Dec 16, 2020 - Dec 18, 2020	-8.41% Jul 16, 2024 - Sep 19, 2024
#14	-0.08% Dec 14, 2020 - Dec 16, 2020	-7.35% Sep 14, 2012 - Jan 2, 2013
#15	N/A	-7.27% Sep 18, 2014 - Oct 31, 2014