DNLI vs ACAD

Comparison between Denali Therapeutics Inc (DNLI, Company) and Acadia Pharmaceuticals Inc (ACAD, Company).

Both DNLI and ACAD are from the Healthcare sector.

5-Year PerformanceACAD has outperformed DNLI, delivering a return of -3.6% compared to -20.6%

DNLI vs ACAD - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	DNLI(COMPANY)	ACAD(COMPANY)
Market Cap	$3.70B	$3.70B
Max Drawdown	87.74%	96.29%
Sharpe Ratio	1.11	-0.06
5Y Beta	1.51	0.92
Industry	Biotechnology	Biotechnology
P/E Ratio	-6.96	9.78
Forward P/E	N/A	60.61
PEG Ratio	-1.09	0.16
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-11.41%	3.07%

Market Cap

DNLI

$3.70B

Winner

ACAD

$3.70B

Max Drawdown

Winner

DNLI

87.74%

ACAD

96.29%

Sharpe Ratio

Winner

DNLI

1.11

ACAD

-0.06

5Y Beta

DNLI

1.51

Winner

ACAD

0.92

Industry

DNLI

Biotechnology

ACAD

Biotechnology

P/E Ratio

Winner

DNLI

-6.96

ACAD

9.78

Forward P/E

DNLI

N/A

ACAD

60.61

PEG Ratio

Winner

DNLI

-1.09

ACAD

0.16

Debt to Equity

DNLI

0.00%

ACAD

0.00%

Free Cash Flow Yield

DNLI

-11.41%

Winner

ACAD

3.07%

DNLI vs ACAD - Historical Returns

Returns include dividend reinvestment.

Period	DNLI	ACAD
1 month	+26.68%	+4.49%
3 months	+16.20%	+6.40%
6 months	+39.00%	-18.72%
1 year	+65.44%	-5.80%
5 years(CAGR)	-20.57%	-3.65%
10 years(CAGR)	+0.98%	-5.33%
Max(CAGR)	+0.98%	+5.45%

Winner

DNLI

+26.68%

ACAD

+4.49%

Winner

DNLI

+16.20%

ACAD

+6.40%

Winner

DNLI

+39.00%

ACAD

-18.72%

Winner

DNLI

+65.44%

ACAD

-5.80%

5Y(CAGR)

DNLI

-20.57%

Winner

ACAD

-3.65%

10Y(CAGR)

Winner

DNLI

+0.98%

ACAD

-5.33%

Max(CAGR)

DNLI

+0.98%

Winner

ACAD

+5.45%

DNLI vs ACAD - Annual Returns (2004 - 2026)

Returns include dividend reinvestment.

Year	DNLI	ACAD
2026	+43.27%	-17.76%
2025	-20.78%	+43.14%
2024	-4.72%	-40.54%
2023	-22.33%	+91.85%
2022	-41.17%	-34.73%
2021	-37.06%	-55.80%
2020	+411.04%	+30.04%
2019	-9.88%	+156.94%
2018	+28.08%	-46.86%
2017	-27.09%	+4.66%
2016	N/A	-16.70%
2015	N/A	+14.45%
2014	N/A	+26.24%
2013	N/A	+428.33%
2012	N/A	+318.92%
2011	N/A	-11.48%
2010	N/A	-11.76%
2009	N/A	+18.92%
2008	N/A	-91.71%
2007	N/A	+26.23%
2006	N/A	-12.01%
2005	N/A	+54.15%
2004	N/A	+1.04%

DNLI vs ACAD Drawdown Comparison

The maximum drawdown for DNLI was -87.74%, occurring on Apr 8, 2025. This drawdown has not yet recovered.

The maximum drawdown for ACAD was -96.29%, occurring on Nov 12, 2010. Recovery took 1820 trading sessions.

The current DNLI drawdown is -75.09%. The current ACAD drawdown is -62.07%.

Rank	DNLI	ACAD
#1	-87.74% Dec 22, 2020 - Apr 8, 2025	-96.29% Mar 16, 2006 - Jun 10, 2013
#2	-49.76% Feb 16, 2018 - Apr 2, 2019	-77.18% Jul 7, 2020 - Jun 21, 2022
#3	-49.54% Apr 10, 2019 - Jun 2, 2020	-73.99% Jul 17, 2015 - Dec 5, 2019
#4	-29.88% Dec 8, 2017 - Jan 22, 2018	-40.80% Feb 27, 2014 - Dec 2, 2014
#5	-19.74% Jun 3, 2020 - Aug 6, 2020	-38.42% Dec 6, 2019 - Apr 27, 2020
#6	-19.58% Jan 29, 2018 - Feb 16, 2018	-33.81% Mar 10, 2015 - Jul 14, 2015
#7	-13.33% Nov 12, 2020 - Dec 4, 2020	-31.14% Oct 2, 2013 - Feb 25, 2014
#8	-11.16% Aug 10, 2020 - Aug 25, 2020	-25.79% Sep 15, 2004 - Feb 8, 2005
#9	-10.43% Sep 17, 2020 - Oct 7, 2020	-25.26% Jun 17, 2004 - Sep 1, 2004
#10	-10.33% Oct 13, 2020 - Oct 27, 2020	-23.54% Oct 19, 2005 - Jan 31, 2006
#11	-9.64% Aug 25, 2020 - Sep 14, 2020	-21.59% Feb 9, 2005 - May 24, 2005
#12	-7.28% Oct 28, 2020 - Nov 4, 2020	-14.01% May 20, 2020 - Jun 23, 2020
#13	-3.20% Jan 23, 2018 - Jan 26, 2018	-13.93% Jun 10, 2013 - Jul 15, 2013
#14	-2.37% Apr 3, 2019 - Apr 5, 2019	-13.41% Apr 27, 2020 - May 18, 2020
#15	-1.33% Dec 16, 2020 - Dec 18, 2020	-13.09% Jun 16, 2005 - Jul 20, 2005