DH vs SPRO

Comparison between Definitive Healthcare Corp - Class A (DH, Company) and Spero Therapeutics Inc (SPRO, Company).

Both DH and SPRO are from the Healthcare sector.

5-Year PerformanceSPRO has outperformed DH, delivering a return of -39.5% compared to -57.4%

DH vs SPRO - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	DH(COMPANY)	SPRO(COMPANY)
Market Cap	$73M	$74M
Max Drawdown	98.72%	97.46%
Sharpe Ratio	-2.13	-0.84
5Y Beta	1.02	0.67
Industry	Health Information Services	Biotechnology
P/E Ratio	-0.28	4.65
Forward P/E	4.24	N/A
PEG Ratio	N/A	0.00
5Y Dividends CAGR	N/A	30.26%
Debt to Equity	85.34%	0.00%
Free Cash Flow Yield	36.88%	9.85%
P/S Ratio	0.31	1.20
P/B Ratio	0.52	1.50

Market Cap

$73M

Winner

SPRO

$74M

Max Drawdown

98.72%

Winner

SPRO

97.46%

Sharpe Ratio

-2.13

Winner

SPRO

-0.84

5Y Beta

1.02

Winner

SPRO

0.67

Industry

Health Information Services

SPRO

Biotechnology

P/E Ratio

Winner

-0.28

SPRO

4.65

Forward P/E

4.24

SPRO

N/A

PEG Ratio

N/A

SPRO

0.00

5Y Dividends CAGR

N/A

SPRO

30.26%

Debt to Equity

85.34%

Winner

SPRO

0.00%

Free Cash Flow Yield

Winner

36.88%

SPRO

9.85%

P/S Ratio

Winner

0.31

SPRO

1.20

P/B Ratio

Winner

0.52

SPRO

1.50

DH vs SPRO - Historical Returns

Returns include dividend reinvestment.

Period	DH	SPRO
1 month	-6.96%	-46.05%
3 months	-31.40%	-58.57%
6 months	-71.77%	-52.46%
1 year	-83.82%	-51.26%
5 years(CAGR)	-57.44%	-39.52%
10 years(CAGR)	N/A	-10.05%
Max(CAGR)	-57.44%	-4.36%

Winner

-6.96%

SPRO

-46.05%

Winner

-31.40%

SPRO

-58.57%

-71.77%

Winner

SPRO

-52.46%

-83.82%

Winner

SPRO

-51.26%

5Y(CAGR)

-57.44%

Winner

SPRO

-39.52%

10Y(CAGR)

N/A

SPRO

-10.05%

Max(CAGR)

-57.44%

Winner

SPRO

-4.36%

DH vs SPRO - Annual Returns (2004 - 2026)

Returns include dividend reinvestment.

Year	DH	SPRO
2026	-71.12%	-50.64%
2025	-30.34%	+115.74%
2024	-59.51%	-32.24%
2023	-11.25%	-15.52%
2022	-60.96%	-88.58%
2021	-36.87%	-10.71%
2020	N/A	+96.45%
2019	N/A	+53.59%
2018	N/A	-49.34%
2017	N/A	+2.17%
2015	N/A	+125.03%
2014	N/A	-36.85%
2013	N/A	+87.73%
2012	N/A	-15.94%
2011	N/A	-18.88%
2010	N/A	-29.17%
2009	N/A	+37.55%
2008	N/A	-59.66%
2007	N/A	+44.06%
2006	N/A	+26.56%
2005	N/A	-15.34%
2004	N/A	+7.04%

DH vs SPRO Drawdown Comparison

The maximum drawdown for DH was -98.72%, occurring on Jun 25, 2026. This drawdown has not yet recovered.

The maximum drawdown for SPRO was -97.46%, occurring on Apr 8, 2025. This drawdown has not yet recovered.

The current DH drawdown is -98.60%. The current SPRO drawdown is -94.74%.

Rank	DH	SPRO
#1	-98.72% Sep 17, 2021 - Jun 25, 2026	-97.46% Dec 28, 2020 - Apr 8, 2025
#2	N/A	-85.13% Jul 17, 2007 - Nov 2, 2017
#3	N/A	-70.48% Apr 12, 2018 - Dec 8, 2020
#4	N/A	-42.56% May 17, 2005 - Feb 16, 2007
#5	N/A	-32.47% Nov 13, 2017 - Apr 9, 2018
#6	N/A	-18.79% Mar 12, 2007 - Jun 19, 2007
#7	N/A	-9.16% Jun 25, 2007 - Jul 3, 2007
#8	N/A	-8.75% Dec 3, 2004 - Mar 28, 2005
#9	N/A	-5.73% Feb 21, 2007 - Mar 7, 2007
#10	N/A	-5.34% Dec 8, 2020 - Dec 16, 2020
#11	N/A	-4.94% Mar 28, 2005 - May 11, 2005
#12	N/A	-4.48% Dec 17, 2020 - Dec 21, 2020
#13	N/A	-4.01% Jul 9, 2007 - Jul 13, 2007
#14	N/A	-2.82% Nov 22, 2004 - Nov 24, 2004
#15	N/A	-2.50% Nov 24, 2004 - Dec 1, 2004