COLL vs ANNX

Comparison between Collegium Pharmaceutical Inc (COLL, Company) and Annexon Inc (ANNX, Company).

Both COLL and ANNX are from the Healthcare sector.

5-Year PerformanceCOLL has outperformed ANNX, delivering a return of +9.3% compared to -24.3%

COLL vs ANNX - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	COLL(COMPANY)	ANNX(COMPANY)
Market Cap	$1.16B	$1.16B
Max Drawdown	73.59%	96.06%
Sharpe Ratio	0.32	1.28
5Y Beta	0.50	1.22
Industry	Drug Manufacturers - Specialty & Generic	Biotechnology
P/E Ratio	39.32	-4.61
Forward P/E	4.82	N/A
PEG Ratio	0.00	-0.28
5Y EPS CAGR	-5.45%	N/A
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	28.41%	-15.82%
P/S Ratio	1.46	N/A
P/B Ratio	3.84	4.37

Market Cap

Winner

COLL

$1.16B

ANNX

$1.16B

Max Drawdown

Winner

COLL

73.59%

ANNX

96.06%

Sharpe Ratio

COLL

0.32

Winner

ANNX

1.28

5Y Beta

Winner

COLL

0.50

ANNX

1.22

Industry

COLL

Drug Manufacturers - Specialty & Generic

ANNX

Biotechnology

P/E Ratio

COLL

39.32

Winner

ANNX

-4.61

Forward P/E

COLL

4.82

ANNX

N/A

PEG Ratio

COLL

0.00

Winner

ANNX

-0.28

5Y EPS CAGR

COLL

-5.45%

ANNX

N/A

Debt to Equity

COLL

0.00%

ANNX

0.00%

Free Cash Flow Yield

Winner

COLL

28.41%

ANNX

-15.82%

P/S Ratio

COLL

1.46

ANNX

N/A

P/B Ratio

Winner

COLL

3.84

ANNX

4.37

COLL vs ANNX - Historical Returns

Returns include dividend reinvestment.

Period	COLL	ANNX
1 month	+1.24%	+22.88%
3 months	-0.68%	-0.85%
6 months	-22.64%	+10.48%
1 year	+6.76%	+107.14%
5 years(CAGR)	+9.31%	-24.25%
10 years(CAGR)	+10.81%	N/A
Max(CAGR)	+9.88%	-17.12%

COLL

+1.24%

Winner

ANNX

+22.88%

Winner

COLL

-0.68%

ANNX

-0.85%

COLL

-22.64%

Winner

ANNX

+10.48%

COLL

+6.76%

Winner

ANNX

+107.14%

5Y(CAGR)

Winner

COLL

+9.31%

ANNX

-24.25%

10Y(CAGR)

COLL

+10.81%

ANNX

N/A

Max(CAGR)

Winner

COLL

+9.88%

ANNX

-17.12%

COLL vs ANNX - Annual Returns (2015 - 2026)

Returns include dividend reinvestment.

Year	COLL	ANNX
2026	-22.62%	+23.67%
2025	+61.72%	-8.73%
2024	-8.26%	+5.99%
2023	+30.53%	-5.22%
2022	+21.53%	-56.70%
2021	-5.94%	-51.94%
2020	-7.27%	+40.93%
2019	+15.62%	N/A
2018	-8.18%	N/A
2017	+17.73%	N/A
2016	-40.64%	N/A
2015	+123.76%	N/A

COLL vs ANNX Drawdown Comparison

The maximum drawdown for COLL was -73.59%, occurring on May 8, 2017. Recovery took 550 trading sessions.

The maximum drawdown for ANNX was -96.06%, occurring on Apr 10, 2025. This drawdown has not yet recovered.

The current COLL drawdown is -29.31%. The current ANNX drawdown is -83.43%.

Rank	COLL	ANNX
#1	-73.59% Dec 30, 2015 - Mar 8, 2018	-96.06% Mar 16, 2021 - Apr 10, 2025
#2	-65.22% Mar 8, 2018 - Feb 1, 2023	-31.37% Oct 16, 2020 - Dec 23, 2020
#3	-41.07% Oct 4, 2024 - Nov 7, 2025	-27.99% Dec 23, 2020 - Feb 22, 2021
#4	-38.84% Dec 26, 2025 - Jun 2, 2026	-25.64% Aug 12, 2020 - Sep 30, 2020
#5	-35.05% Jul 31, 2015 - Sep 16, 2015	-13.04% Feb 22, 2021 - Mar 11, 2021
#6	-33.28% Sep 18, 2015 - Dec 14, 2015	-10.78% Sep 30, 2020 - Oct 16, 2020
#7	-29.52% Feb 2, 2023 - Dec 18, 2023	-3.12% Aug 3, 2020 - Aug 5, 2020
#8	-23.34% Mar 27, 2024 - Oct 4, 2024	-3.02% Aug 5, 2020 - Aug 10, 2020
#9	-14.67% Jun 11, 2015 - Jul 31, 2015	-2.83% Jul 29, 2020 - Aug 3, 2020
#10	-12.81% Dec 17, 2015 - Dec 30, 2015	-1.46% Jul 24, 2020 - Jul 28, 2020
#11	-7.18% Nov 12, 2025 - Dec 2, 2025	-0.38% Mar 11, 2021 - Mar 15, 2021
#12	-6.45% Feb 15, 2024 - Feb 23, 2024	N/A
#13	-6.29% May 22, 2015 - Jun 3, 2015	N/A
#14	-6.26% Jan 3, 2024 - Jan 29, 2024	N/A
#15	-5.02% Jan 29, 2024 - Feb 15, 2024	N/A

Correlation

Correlation between COLL and ANNX is -0.36 which considered as a weak negative correlation - the stocks show a slight tendency to move in opposite directions.

-0.36

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