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CNTA vs SPY

Comparison between Centessa Pharmaceuticals plc (CNTA, Company) and SPDR S&P 500 ETF Trust (SPY, ETF).

5-Year PerformanceSPY has outperformed CNTA, delivering a return of +12.9% compared to +10.6%

CNTA vs SPY - Performance Comparison

Key Characteristics

Financial metrics and valuation ratios

Market Cap / Net Assets
CNTA
$6.27B
Winner
SPY
$784B
Expense Ratio
CNTA
N/A
SPY
0.09%
Max Drawdown
CNTA
88.19%
Winner
SPY
56.47%
Sharpe Ratio
Winner
CNTA
1.84
SPY
1.35
5Y Beta
CNTA
N/A
SPY
1.00
Industry
CNTA
Biotechnology
SPY
N/A
P/E Ratio
Winner
CNTA
-23.28
SPY
28.30
Forward P/E
CNTA
N/A
SPY
21.43
Dividend Yield
CNTA
93.80%
SPY
N/A
5Y Dividends CAGR
CNTA
N/A
SPY
6.00%
5Y EPS CAGR
CNTA
N/A
SPY
25.31%
Debt to Equity
Winner
CNTA
22.66%
SPY
31.81%
Free Cash Flow Yield
CNTA
-3.34%
SPY
N/A
P/S Ratio
CNTA
N/A
SPY
3.67
P/B Ratio
CNTA
N/A
SPY
5.56

CNTA vs SPY - Historical Returns

Returns include dividend reinvestment.

1M
Winner
CNTA
+1.81%
SPY
-1.70%
3M
Winner
CNTA
+43.52%
SPY
+13.85%
6M
Winner
CNTA
+57.71%
SPY
+9.60%
1Y
Winner
CNTA
+201.56%
SPY
+21.37%
5Y(CAGR)
CNTA
+10.58%
Winner
SPY
+12.94%
10Y(CAGR)
CNTA
N/A
SPY
+15.34%
Max(CAGR)
Winner
CNTA
+13.03%
SPY
+8.50%

CNTA vs SPY - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

YearCNTASPY
2026+70.96%+9.60%
2025+42.91%+18.00%
2024+108.59%+25.59%
2023+154.31%+26.72%
2022-73.25%-18.64%
2021-48.23%+30.52%
2020N/A+17.28%
2019N/A+31.09%
2018N/A-5.24%
2017N/A+20.78%
2016N/A+13.59%
2015N/A+1.31%
2014N/A+14.56%
2013N/A+29.00%
2012N/A+14.17%
2011N/A+0.85%
2010N/A+13.14%
2009N/A+22.67%
2008N/A-36.25%
2007N/A+5.32%
2006N/A+13.85%
2005N/A+5.32%
2004N/A+10.75%
2003N/A+24.18%
2002N/A-22.42%
2001N/A-10.13%
2000N/A-8.84%
1999N/A+8.61%

CNTA vs SPY Drawdown Comparison

The maximum drawdown for CNTA was -88.19%, occurring on Feb 16, 2023. Recovery took 1107 trading sessions.

The maximum drawdown for SPY was -55.20%, occurring on Mar 9, 2009. Recovery took 1224 trading sessions.

The current SPY drawdown is -1.70%.

RankCNTASPY
#1-88.19%
Jun 17, 2021 - Nov 12, 2025		-55.20%
Oct 9, 2007 - Aug 16, 2012
#2-26.38%
Dec 5, 2025 - Mar 31, 2026		-47.50%
Mar 24, 2000 - Oct 26, 2006
#3-13.54%
Jun 2, 2021 - Jun 17, 2021		-33.70%
Feb 19, 2020 - Aug 10, 2020
#4-3.06%
Nov 24, 2025 - Dec 4, 2025		-24.50%
Jan 3, 2022 - Dec 13, 2023
#5-2.89%
Nov 18, 2025 - Nov 24, 2025		-19.34%
Sep 20, 2018 - Apr 12, 2019
#6-2.73%
Nov 12, 2025 - Nov 14, 2025		-18.76%
Feb 19, 2025 - Jun 26, 2025
#7-1.10%
Apr 1, 2026 - Jun 2, 2026		-13.02%
Jul 20, 2015 - Apr 18, 2016
#8-1.05%
Nov 14, 2025 - Nov 18, 2025		-10.10%
Jan 26, 2018 - Aug 6, 2018
#9-0.70%
Jun 2, 2026 - Jun 18, 2026		-9.44%
Sep 2, 2020 - Nov 11, 2020
#10N/A-9.30%
Jan 19, 2000 - Mar 17, 2000
#11N/A-9.05%
Jul 19, 2007 - Oct 5, 2007
#12N/A-8.88%
Jan 27, 2026 - Apr 14, 2026
#13N/A-8.41%
Jul 16, 2024 - Sep 19, 2024
#14N/A-7.35%
Sep 14, 2012 - Jan 2, 2013
#15N/A-7.27%
Sep 18, 2014 - Oct 31, 2014

Correlation

Correlation between CNTA and SPY is 0.80 which considered as a strong positive correlation - the stocks tend to move together.

0.80
-101

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