CANC vs PSCI

Comparison between Tema Oncology ETF (CANC, ETF) and INVESCO S&P SMALLCAP INDUSTRIALS ETF (PSCI, ETF).

CANC is from the Healthcare sector, while PSCI is from the Industrials sector.

5-Year PerformancePSCI has outperformed CANC, delivering a return of +14.3% compared to -9.4%

CANC vs PSCI - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	CANC(ETF)	PSCI(ETF)
Net Assets	$176M	$176M
Expense Ratio	0.75%	0.29%
Max Drawdown	97.53%	46.25%
Sharpe Ratio	1.52	1.37
5Y Beta	0.75	1.12
P/E Ratio	-24.37	35.76
Forward P/E	N/A	17.43
5Y Dividends CAGR	N/A	29.41%
5Y EPS CAGR	11.01%	19.75%
Debt to Equity	58.15%	70.49%
P/S Ratio	8.49	1.19
P/B Ratio	5.96	2.64

Net Assets

CANC

$176M

PSCI

$176M

Expense Ratio

CANC

0.75%

Winner

PSCI

0.29%

Max Drawdown

CANC

97.53%

Winner

PSCI

46.25%

Sharpe Ratio

Winner

CANC

1.52

PSCI

1.37

5Y Beta

Winner

CANC

0.75

PSCI

1.12

P/E Ratio

Winner

CANC

-24.37

PSCI

35.76

Forward P/E

CANC

N/A

PSCI

17.43

5Y Dividends CAGR

CANC

N/A

PSCI

29.41%

5Y EPS CAGR

CANC

11.01%

Winner

PSCI

19.75%

Debt to Equity

Winner

CANC

58.15%

PSCI

70.49%

P/S Ratio

CANC

8.49

Winner

PSCI

1.19

P/B Ratio

CANC

5.96

Winner

PSCI

2.64

CANC vs PSCI - Holdings Comparison

CANC and PSCI have 1 common holdings. Overlap is 0.00%

CANC's top 25 holdings weight is 76.89%. PSCI's top 25 holdings weight is 53.28%.

Rank	CANC	PSCI
#1	REVOLUTION MEDICINES INC ORDINARY SHARES (RVMD) - 7.31%	ARGAN INC (AGX) - 3.17%
#2	ELI LILLY AND CO (LLY) - 4.25%	POWELL INDUSTRIES INC (POWL) - 2.83%
#3	IMMUNOME INC ORDINARY SHARES (IMNM) - 4.21%	ESCO TECHNOLOGIES INC (ESE) - 2.69%
#4	COGENT BIOSCIENCES INC (COGT) - 4.08%	EVERUS CONSTRUCTION GROUP INC (ECG) - 2.63%
#5	ROCHE HOLDING AG ADR (RHHBY) - 4.07%	ZURN ELKAY WATER SOLUTIONS CORP (ZWS) - 2.47%
#6	NOVARTIS AG REGISTERED SHARES (n/a) - 4.00%	MYR GROUP INC (MYRG) - 2.46%
#7	CELCUITY INC (CELC) - 3.93%	FEDERAL SIGNAL CORP (FSS) - 2.42%
#8	ASTRAZENECA PLC (AZN:XLON) - 3.50%	JBT MAREL CORP (JBTM) - 2.39%
#9	MERCK & CO INC (MRK) - 3.43%	PRIMORIS SERVICES CORP (PRIM) - 2.38%
#10	BRISTOL-MYERS SQUIBB CO (BMY) - 3.34%	ARMSTRONG WORLD INDUSTRIES INC (AWI) - 2.35%
#11	NUVALENT INC CLASS A (NUVL) - 3.15%	ENPRO INC (NPO) - 2.29%
#12	LEGEND BIOTECH CORP ADR (LEGN) - 2.94%	PAYCOM SOFTWARE INC (PAYC) - 2.21%
#13	GENMAB AS ADR (GMAB) - 2.87%	GATES INDUSTRIAL CORP PLC (GTES) - 2.19%
#14	ABBVIE INC (ABBV) - 2.70%	ARCOSA INC (ACA) - 2.10%
#15	BRIDGEBIO PHARMA INC (BBIO) - 2.63%	GRANITE CONSTRUCTION INC (GVA) - 1.98%
#16	CG ONCOLOGY INC (CGON) - 2.56%	MATSON INC (MATX) - 1.96%
#17	JOHNSON & JOHNSON (JNJ) - 2.55%	CASELLA WASTE SYSTEMS INC CLASS A (CWST) - 1.86%
#18	ZAI LAB LTD ADR REPR 1 SHS (ZLAB) - 2.49%	LYFT INC CLASS A (LYFT) - 1.84%
#19	EXELIXIS INC (EXEL) - 2.45%	MERCURY SYSTEMS INC (MRCY) - 1.79%
#20	IDEAYA BIOSCIENCES INC (IDYA) - 2.10%	VSE CORP (VSEC) - 1.71%
#21	AMGEN INC (AMGN) - 2.04%	n/a (WSC) - 1.60%
#22	BEONE MEDICINES LTD ADR (ONC) - 1.95%	CSW INDUSTRIALS INC (CSW) - 1.57%
#23	ZYMEWORKS INC REGISTERED SHS (ZYME) - 1.62%	AAR CORP (AIR) - 1.50%
#24	FIRST AMERICAN TREASURY OBLIGS X (FXFXX) - 1.47%	RUSH ENTERPRISES INC CLASS A (RUSHA) - 1.45%
#25	ANAPTYSBIO INC (ANAB) - 1.25%	AZZ INC (AZZ) - 1.44%
Total Holdings	57	93

CANC vs PSCI - Historical Returns

Returns include dividend reinvestment.

Period	CANC	PSCI
1 month	-0.45%	+4.05%
3 months	+3.17%	+15.12%
6 months	+8.22%	+14.61%
1 year	+43.36%	+38.51%
5 years(CAGR)	-9.38%	+14.29%
10 years(CAGR)	N/A	+15.38%
Max(CAGR)	-9.38%	+13.72%

CANC

-0.45%

Winner

PSCI

+4.05%

CANC

+3.17%

Winner

PSCI

+15.12%

CANC

+8.22%

Winner

PSCI

+14.61%

Winner

CANC

+43.36%

PSCI

+38.51%

5Y(CAGR)

CANC

-9.38%

Winner

PSCI

+14.29%

10Y(CAGR)

CANC

N/A

PSCI

+15.38%

Max(CAGR)

CANC

-9.38%

Winner

PSCI

+13.72%

CANC vs PSCI - Annual Returns (2010 - 2026)

Returns include dividend reinvestment.

Year	CANC	PSCI
2026	+8.37%	+15.80%
2025	+42.13%	+13.61%
2024	-6.11%	+17.82%
2023	+515.06%	+31.51%
2022	-85.58%	-9.56%
2021	-51.82%	+26.99%
2020	N/A	+11.74%
2019	N/A	+28.17%
2018	N/A	-13.21%
2017	N/A	+16.17%
2016	N/A	+32.94%
2015	N/A	-3.37%
2014	N/A	+4.58%
2013	N/A	+38.50%
2012	N/A	+16.89%
2011	N/A	-7.35%
2010	N/A	+16.07%

CANC vs PSCI Drawdown Comparison

The maximum drawdown for CANC was -97.53%, occurring on Apr 5, 2023. This drawdown has not yet recovered.

The maximum drawdown for PSCI was -45.54%, occurring on Mar 23, 2020. Recovery took 569 trading sessions.

The current CANC drawdown is -55.25%.

Rank	CANC	PSCI
#1	-97.53% Oct 20, 2021 - Apr 5, 2023	-45.54% Aug 21, 2018 - Nov 23, 2020
#2	-16.18% Oct 5, 2021 - Oct 20, 2021	-29.42% Apr 6, 2011 - Sep 13, 2012
#3	N/A	-29.36% Nov 25, 2024 - Aug 13, 2025
#4	N/A	-24.78% Nov 11, 2021 - Jun 7, 2023
#5	N/A	-21.32% Jun 22, 2015 - Jul 12, 2016
#6	N/A	-19.59% Apr 26, 2010 - Dec 1, 2010
#7	N/A	-14.88% Feb 6, 2026 - Jun 12, 2026
#8	N/A	-14.24% Mar 6, 2014 - Dec 26, 2014
#9	N/A	-12.72% Aug 1, 2023 - Dec 4, 2023
#10	N/A	-11.81% May 7, 2021 - Nov 3, 2021
#11	N/A	-9.62% Jul 31, 2024 - Oct 16, 2024
#12	N/A	-9.35% Jan 22, 2014 - Mar 6, 2014
#13	N/A	-8.68% Mar 20, 2013 - May 15, 2013
#14	N/A	-8.60% Oct 24, 2025 - Dec 10, 2025
#15	N/A	-8.54% Mar 12, 2021 - May 7, 2021

Correlation

Correlation between CANC and PSCI is 0.56 which considered as a moderate positive correlation - the stocks show some tendency to move together.

0.56

-101

Dividend Comparison (2010 - 2026)

CANC vs PSCI dividend yield comparison.

Year	CANC	PSCI
2026	0.00%	0.12%
2025	0.06%	1.56%
2024	3.00%	0.65%
2023	0.56%	0.72%
2022	0.00%	0.87%
2021	0.00%	0.69%
2020	0.00%	0.59%
2019	0.00%	0.64%
2018	0.00%	0.67%
2017	0.00%	0.71%
2016	0.00%	0.74%
2015	0.00%	1.02%
2014	0.00%	0.81%
2013	0.00%	0.47%
2012	0.00%	2.11%
2011	0.00%	0.64%
2010	0.00%	0.49%