AXSM vs GWRE

Comparison between Axsome Therapeutics Inc (AXSM, Company) and Guidewire Software Inc (GWRE, Company).

AXSM is from the Healthcare sector, while GWRE is from the Technology sector.

5-Year PerformanceAXSM has outperformed GWRE, delivering a return of +33.0% compared to +7.2%

AXSM vs GWRE - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	AXSM(COMPANY)	GWRE(COMPANY)
Market Cap	$12B	$12B
Max Drawdown	86.65%	60.28%
Sharpe Ratio	2.07	-0.70
5Y Beta	0.68	0.76
Industry	Biotechnology	Software - Application
P/E Ratio	-62.02	118.56
Forward P/E	333.33	36.23
PEG Ratio	0.00	0.86
5Y EPS CAGR	6.89%	N/A
Debt to Equity	344.13%	0.00%
Free Cash Flow Yield	-0.60%	2.61%
P/S Ratio	16.82	8.86
P/B Ratio	217.41	7.83

Market Cap

AXSM

$12B

Winner

GWRE

$12B

Max Drawdown

AXSM

86.65%

Winner

GWRE

60.28%

Sharpe Ratio

Winner

AXSM

2.07

GWRE

-0.70

5Y Beta

Winner

AXSM

0.68

GWRE

0.76

Industry

AXSM

Biotechnology

GWRE

Software - Application

P/E Ratio

Winner

AXSM

-62.02

GWRE

118.56

Forward P/E

AXSM

333.33

Winner

GWRE

36.23

PEG Ratio

Winner

AXSM

0.00

GWRE

0.86

5Y EPS CAGR

AXSM

6.89%

GWRE

N/A

Debt to Equity

AXSM

344.13%

Winner

GWRE

0.00%

Free Cash Flow Yield

AXSM

-0.60%

Winner

GWRE

2.61%

P/S Ratio

AXSM

16.82

Winner

GWRE

8.86

P/B Ratio

AXSM

217.41

Winner

GWRE

7.83

AXSM vs GWRE - Historical Returns

Returns include dividend reinvestment.

Period	AXSM	GWRE
1 month	+24.97%	+0.54%
3 months	+43.51%	-4.66%
6 months	+55.12%	-35.69%
1 year	+125.24%	-34.39%
5 years(CAGR)	+33.03%	+7.15%
10 years(CAGR)	+38.89%	+9.00%
Max(CAGR)	+36.71%	+15.64%

Winner

AXSM

+24.97%

GWRE

+0.54%

Winner

AXSM

+43.51%

GWRE

-4.66%

Winner

AXSM

+55.12%

GWRE

-35.69%

Winner

AXSM

+125.24%

GWRE

-34.39%

5Y(CAGR)

Winner

AXSM

+33.03%

GWRE

+7.15%

10Y(CAGR)

Winner

AXSM

+38.89%

GWRE

+9.00%

Max(CAGR)

Winner

AXSM

+36.71%

GWRE

+15.64%

AXSM vs GWRE - Annual Returns (2012 - 2026)

Returns include dividend reinvestment.

Year	AXSM	GWRE
2026	+31.06%	-26.79%
2025	+109.16%	+18.59%
2024	+9.80%	+57.92%
2023	+8.55%	+73.35%
2022	+103.89%	-44.78%
2021	-53.61%	-9.94%
2020	-19.58%	+16.94%
2019	+3756.72%	+39.43%
2018	-48.49%	+7.75%
2017	-13.18%	+45.64%
2016	-44.63%	-15.17%
2015	+6.06%	+20.39%
2014	N/A	+5.17%
2013	N/A	+59.06%
2012	N/A	+73.60%

AXSM vs GWRE Drawdown Comparison

The maximum drawdown for AXSM was -86.65%, occurring on Dec 27, 2018. Recovery took 809 trading sessions.

The maximum drawdown for GWRE was -60.28%, occurring on Nov 9, 2022. Recovery took 861 trading sessions.

The current AXSM drawdown is -0.75%. The current GWRE drawdown is -47.55%.

Rank	AXSM	GWRE
#1	-86.65% Jan 5, 2016 - Mar 25, 2019	-60.28% Jan 7, 2021 - Jun 11, 2024
#2	-81.26% Dec 26, 2019 - Jan 30, 2025	-54.96% Sep 8, 2025 - Apr 10, 2026
#3	-42.70% Sep 16, 2019 - Nov 19, 2019	-39.66% Feb 19, 2020 - Nov 27, 2020
#4	-30.56% Feb 21, 2025 - Nov 6, 2025	-39.26% Mar 4, 2014 - Jul 20, 2015
#5	-18.50% Jan 21, 2026 - Apr 30, 2026	-35.62% Mar 26, 2012 - Feb 27, 2013
#6	-17.63% Mar 25, 2019 - Apr 25, 2019	-30.52% Sep 14, 2018 - May 16, 2019
#7	-17.48% Jul 26, 2019 - Sep 16, 2019	-30.45% Dec 29, 2015 - Jun 6, 2016
#8	-17.26% May 28, 2019 - Jun 20, 2019	-23.59% Feb 5, 2025 - Jun 4, 2025
#9	-11.38% Jun 20, 2019 - Jun 27, 2019	-22.80% Sep 7, 2016 - May 24, 2017
#10	-10.33% Nov 24, 2015 - Dec 29, 2015	-19.23% Jun 9, 2025 - Sep 5, 2025
#11	-9.37% Jul 2, 2019 - Jul 26, 2019	-18.61% Dec 4, 2024 - Jan 29, 2025
#12	-8.83% Dec 4, 2019 - Dec 10, 2019	-15.65% Jul 23, 2015 - Nov 27, 2015
#13	-8.26% Dec 31, 2025 - Jan 20, 2026	-14.88% Nov 24, 2017 - Mar 2, 2018
#14	-7.23% Feb 5, 2025 - Feb 10, 2025	-14.51% Nov 26, 2019 - Feb 19, 2020
#15	-6.21% Nov 28, 2025 - Dec 19, 2025	-14.08% Oct 29, 2013 - Feb 20, 2014